Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers

Costa, Alfredo; Bosone, Daniele; Zoppi, Annalisa; Angelo, Angela D Apos; Ghiotto, Natascia; Guaschino, Elena; Ramusino, Matteo Cotta; Fogari, Roberto

doi:10.1159/000481665

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…Therefore, it is possible that similar physiological adaptations might have occurred in our participants to reduce HRrest. Contrary, the CON group increased HRrest, despite this outcome, their values match with previous HRrest data reported in healthy young adults [ 46 , 47 , 48 ].…”

Section: Discussionsupporting

confidence: 90%

Hemodynamic Adaptations Induced by Short-Term Run Interval Training in College Students

García-Suárez

Rentería

Wong-Avilés

et al. 2020

IJERPH

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Perceived lack of time is one of the most often cited barriers to exercise participation. High intensity interval training has become a popular training modality that incorporates intervals of maximal and low-intensity exercise with a time commitment usually shorter than 30 min. The purpose of this study was to examine the effects of short-term run interval training (RIT) on body composition (BC) and cardiorespiratory responses in undergraduate college students. Nineteen males (21.5 ± 1.6 years) were randomly assigned to a non-exercise control (CON, n = 10) or RIT (n = 9). Baseline measurements of systolic and diastolic blood pressure, resting heart rate (HRrest), double product (DP) and BC were obtained from both groups. VO2max and running speed associated with VO2peak (sVO2peak) were then measured. RIT consisted of three running treadmill sessions per week over 4 weeks (intervals at 100% sVO2peak, recovery periods at 40% sVO2peak). There were no differences in post-training BC or VO2max between groups (p > 0.05). HRrest (p = 0.006) and DP (p ≤ 0.001) were lower in the RIT group compared to CON at completion of the study. RIT lowered HRrest and DP in the absence of appreciable BC and VO2max changes. Thereby, RIT could be an alternative model of training to diminish health-related risk factors in undergraduate college students.

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Section: Discussionsupporting

confidence: 90%

Hemodynamic Adaptations Induced by Short-Term Run Interval Training in College Students

García-Suárez

Rentería

Wong-Avilés

et al. 2020

IJERPH

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“…The same finding was also reported with diazepam in studies performed with the same method in normotensive subjects [23,26]. It could be a common effect of several benzodiazepines related to their vagolytic action, as suggested by experimental studies.…”

Section: Discussionsupporting

confidence: 81%

“…The second main finding of this study is that after evening bromazepam administration, HR values increased during night-time sleeping hours. The same finding was also reported with diazepam in studies performed with the same method in normotensive subjects [23,26]. It could be a common effect of several benzodiazepines related to their vagolytic action, as suggested by experimental studies.…”

Section: Discussionsupporting

confidence: 81%

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

et al. 2019

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Aim: To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects. Methods: Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg plus propranolol 40 mg or placebo for 2 weeks according to a double-blind, double dummy, cross-over design. After each treatment period, 24-h BP and HR ambulatory monitoring was performed by using a non-invasive device. Results: Ambulatory monitoring showed that during night-time SBP and DBP values were unaffected by bromazepam as compared to placebo, whereas SBP was significantly reduced by propranolol both when taken alone and in combination with bromazepam. HR nocturnal values were significantly reduced by propranolol, whereas they were significantly increased by bromazepan both when taken alone (+11.5%, p < 0.05 vs. placebo) and in combination with propranolol (+12.8%, p < 0.05 vs. propranolol). No significant difference in day-time values of SBP, DBP and HR was observed among the 4 treatment groups. Conclusions: In mild hypertensive patients, evening consumption of bromazepam for a 2-week period did not affect BP, while it increased nocturnal HR. Such an increase was observed both when bromazepam was taken alone and in combination with propranolol, which suggests that it depends on a bromazepam mediated decrease in vagal tone. Whatever the mechanism, the HR nocturnal increase might be of clinical relevance, due to the role of high HR as cardiovascular risk factor, particularly in already at risk hypertensive subjects.

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“…A similar phenomenon is usually observed in elderly patients (Fogari R. et al, 2019). There is a point of view that a similar phenomenon is explained by the increased volume of distribution of diazepam in the body of elderly patients, although a similar effect of the drug is observed in patients of other age groups (Fogari R. et al, 2019, Costa A. et al, 2018.…”

Section: Ukrainian Scientific Medical Youth Journalmentioning

confidence: 94%

Retrospective analysis of the use of benzodiazepines in anxiety disorders

Hryhoriev¹

2023

USMYJ

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in times of great social shocks, economic crises, epidemics and pandemics, military conflicts, usually can be observed the spread of such a group of psychological diseases as anxiety disorders (ADs). ADs are a widespread group of human behavior disorders characterized by a wide range of symptoms that cause significant changes in behavior and reduce the patient's quality of life and may lead to deterioration of his social activity. This group of diseases includes a number of behavioral disorders, the characteristic feature of which is the patient's feeling of fear and/or anxiety, which is usually an excessive and unmotivated reaction to a stimulus or an event that caused them. As a result of the analysis of available data, it was revealed that benzodiazepines are actively used as second-line drugs in ADs pharmacotherapy. The pharmacological effect of this group of medications is associated with an agonistic interaction with GABAA receptors of the central nervous system. It has also been established that this group of drugs is an effective element of complex therapy together with antidepressants or as monotherapy of such ADs as generalized anxiety disorder (GAD), panic disorder (PD), social anxiety disorder (SAD), selective mutism (SM) etc. During ADs therapy with benzodiazepines, a number of side effects, such as excessive sedation, cognitive impairment, and psychomotor disorder of coordination of movements, have been identified. This group of drugs requires special caution when used in elderly patients due to possible excessive sedation and impaired cognitive function. But if the recommended course of treatment is followed, benzodiazepines are a safe to use group of drugs that have a wide spectrum of pharmacological action. The purpose of this work was to study the available data on the pharmacological properties of benzodiazepine anxiolytics for the purpose of their use in the pharmacotherapy of diseases belonging to the ADs group. To achieve this goal, publications and articles devoted to ADs pharmacotherapy methods were reviewed and analyzed. Materials were searched using the databases Pud Med and Google Scholar.

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Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers

Cited by 9 publications

References 25 publications

Hemodynamic Adaptations Induced by Short-Term Run Interval Training in College Students

Hemodynamic Adaptations Induced by Short-Term Run Interval Training in College Students

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

Retrospective analysis of the use of benzodiazepines in anxiety disorders

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