Effect of Diazoxide on Vascular Responses to Norepinephrine in the Calf of Normal Subjects.

Comparison of the Effect of Some Diuretics on Blood Pressure and Renal Haemodynamics in Dogs

“…These facts might explain the recorded reduction in systemic arterial blood pressure, renal blood flow and renal vascular resistance caused by Esidrex@ administration. Moreover, the resultant reduction in systemic arterial blood pressure could be explained by the decrease in pressor responsiveness to physiologically active pressor substances, e. g., norepinephrine has been found to be present after oral administration (ALEKSANDROW et al, 1959;FEISAL et al, 1961;FRIES et al, 1960;ECKSTEIN et al, 1962;and PEREDA et al, 1963), intravenous infusion (BEAVERS and BLACKMORE, 1958), and during intra-arterial infusion (GILLENWATER et al, 1962; and JACKSON and DUFF, 1963) of thiazides.…”

Diazoxide

“…The effect of diazoxide on vascular responses to noradrenaline in the calf of normal subjects was studied by Pereda et al (1963). The administration of 300 mg diazoxide daily for 7 days had no significant effect on the blood pressure (or heart rate) response to infused noradrenaline, although calf blood flow was significantly higher and vascular resistance was significantly lower (the average dose of noradrenaline necessary to produce the same level of vascular resistance after the administration of diazoxide being 3.03 times greater than that required before diazoxide).…”