Effect of diclofenac sodium combined with nuclear rotation on the prevention of posterior capsule opacification: Two-year follow-up

Yao, Yong; Shao, Jun; Tan, Xuhua; Xu, Haolin; Hu, Weiping; Huang, Hongyu; Cai, Ying; Liu, Lixia

doi:10.1016/j.jcrs.2010.11.029

Cited by 5 publications

(4 citation statements)

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“…Estudios científicos de laboratorio realizados en animales sugieren que el uso de fármacos antinfla-matorios no esteroideos después de la intervención de cirugía de cataratas puede reducir la incidencia de OCP (Duong, Westfield y Chalkley, 2007;Inan et al, 2006;Yao et al, 2011). Flach y Dolan (2000) realizaron un estudio prospectivo aleatorizado para determinar la incidencia de OCP tres años después de la intervención, tras tratamientos con diclofenaco al 0,1 % y ketorolaco al 0,5 %, administrados por vía oftálmica cuatro veces al día, durante 30 días.…”

Section: Fármacosunclassified

Opacificación capsular posterior: diagnóstico, prevención y tratamiento con láser Nd-YAG

Tomás-Juan¹

2015

Cienc. Tecnol. Salud Vis. Ocul.

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<p align="justify">La opacificación de la cápsula posterior es una de las complicaciones más frecuentes que suelen producirse después de la cirugía de cataratas, como resultado de una migración y proliferación de restos de células epiteliales que quedan en el saco capsular desde el momento de la intervención. En un principio, esta opacificación se produce en la periferia y luego avanza hacia la zona central, lo que puede afectar, en última instancia y si no se diagnostica a tiempo, la visión central y originar una disminución de la agudeza visual, la sensibilidad al contraste y la sensibilidad al deslumbramiento. El tratamiento necesario para la restauración de la visión consiste en eliminar la opacidad mediante la capsulotomía con láser Nd-YAG. Nuevos diseños y materiales de lentes intraoculares y los hápticos, disposición de anillos de tensión capsular y mejora en la intervención quirúrgica consiguen que en la actualidad la tasa de incidencia de opacidad capsular posterior haya disminuido considerablemente.</p>

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Section: Fármacosunclassified

Opacificación capsular posterior: diagnóstico, prevención y tratamiento con láser Nd-YAG

Tomás-Juan¹

2015

Cienc. Tecnol. Salud Vis. Ocul.

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“…We demonstrated that postoperative long-term use of topical ketorolac drops in pediatric cataract patients with intact posterior capsules prevented PCO formation [ 10 ]. Similarly, hydrodissection using diclofenac sodium prevented PCO up to two years postoperatively [ 11 ]. Moreover, a recent in vitro and in vivo study has demonstrated that IOLs loaded with ketorolac reduce the tendency for adhesion of LECs, and no PCO signs were encountered [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Rate of Posterior Capsule Opacification Following Combined Treatment With Topical Dexamethasone 0.1% Plus Ketorolac 0.5% Eye Drops Versus Dexamethasone 0.1% Alone: A Two-Year, Randomized Clinical Investigation

Evereklioğlu¹,

Arda²,

Şener³

et al. 2023

Cureus

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Background and aimThe use of non-steroidal anti-inflammatory drugs in animals decreases the incidence of posterior capsular opacification (PCO) following cataract surgery. We evaluated the rate of PCO in patients with cataract surgery and foldable "in the bag" posterior chamber intraocular lens (PC-IOL) implantation treated with combined dexamethasone 0.1% plus ketorolac tromethamine 0.5% versus dexamethasone 0.1% alone. Materials and methodsA total of 114 eyes of 101 patients underwent uneventful corneal small-incision phacoemulsification with primary implantation of a foldable acrylic PC-IOL (AcrySof ® , Alcon, Fort Worth, USA). Postoperatively for four weeks, group 1 eyes were treated with dexamethasone 0.1% plus ketorolac tromethamine 0.5% ophthalmic solutions four times daily for each whereas group 2 eyes were treated with dexamethasone 0.1% alone. Other regiments were the same for each group. Patients were evaluated between one-and fouryear following surgery. The frequency and timing of severe PCO following surgery that needed Nd:YAG laser posterior capsulotomy were recorded and evaluated. ResultsThe mean (SEM) age of group 1 (n = 54) and group 2 (n = 60) at operation was similar (62.8 ± 2.2 vs. 60.6 ± 1.7 years, respectively). Eighty-eight patients had unilateral cataract and 13 cases had bilateral disease. Overall, the mean follow-up duration was 24.7 months postoperatively (range, 15-48). Clinically significant PCO that finally needed Nd:YAG laser application developed in two eyes (3.7%) in group 1 and in four eyes (6.6%) in group 2, and the difference was not statistically significant (p>0.05). The mean month at capsulotomy was 26.5 in group 1 and 24.3 months in group 2 eyes (p>0.05). ConclusionsTopical instillation of ketorolac ophthalmic solution in the immediate period after phacoemulsification and PC-IOL implantation did not seem to influence the incidence of PCO formation two years after cataract surgery.

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“…Several risk factors have already been identified for the progression of PCO, which include edge design, intraocular lens design, haptic design, and lens material [4,7] . Currently, there are several techniques introduced for preventing PCO, such as intraocular lens material, surgical techniques, and therapeutic agents [8][9][10] . Acrylic materials show a low ability to stimulate the proliferation of cells in the capsular bag [11] and intraocular lenses with sharp edge design might assist in inhibiting migration of lens epithelial cells [12] ,…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: a Meta-analysis

Wu¹,

Lian²,

Wang³

2022

Int J Ophthalmol

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AIM: To conduct a Meta-analysis pooling randomized controlled trials (RCTs) to compare hydrophobic with hydrophilic acrylic intraocular lenses in terms of posterior capsule opacification (PCO) development. METHODS: Electronic databases including PubMed, Embase, and the Cochrane Library were queried from their starting till January 2020. RCTs investigating the impact of hydrophobic versus hydrophilic acrylic intraocular lenses on PCO were considered eligible in this study. The pooled effect estimates were calculated using the random-effects model. RESULTS: Thirteen RCTs comprising of 939 patients (1263 eyes) were covered in this study. Patients with hydrophobic acrylic intraocular lenses had a lower PCO score than those with a hydrophilic acrylic intraocular lenses [standard mean difference: -1.80; 95% confidence interval (CI): -2.62 to -0.98; P<0.001]. Moreover, the frequency of neodymium-doped yttrium aluminum garnet (Nd:YAG) capsulotomy in patients with hydrophobic acrylic intraocular lenses was significantly lower than patients with hydrophilic acrylic intraocular lenses (relative risk: 0.38; 95%CI: 0.20-0.71; P=0.003). CONCLUSION: These findings suggest that hydrophobic acrylic intraocular lenses are superior to hydrophilic acrylic intraocular lenses in patients after cataract surgery due to lower PCO score and reduced Nd:YAG capsulotomy. While similar studies are conducted by other researchers, the present study conducted subgroup analyses that show superior results with hydrophobic lenses in trials conducted in western countries.

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Effect of diclofenac sodium combined with nuclear rotation on the prevention of posterior capsule opacification: Two-year follow-up

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 5 publications

References 9 publications

Opacificación capsular posterior: diagnóstico, prevención y tratamiento con láser Nd-YAG

Opacificación capsular posterior: diagnóstico, prevención y tratamiento con láser Nd-YAG

Comparison of the Rate of Posterior Capsule Opacification Following Combined Treatment With Topical Dexamethasone 0.1% Plus Ketorolac 0.5% Eye Drops Versus Dexamethasone 0.1% Alone: A Two-Year, Randomized Clinical Investigation

Hydrophobic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: a Meta-analysis

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