Effect of Diclofenac Sodium (Voltaren) on Spermatogenesis of Infertile Oligospermic Patients

Moskovitz, Boaz; Lin, Rongcheng; Nassar, S. M.; Levin, Daniel

doi:10.1159/000472990

Cited by 14 publications

(3 citation statements)

References 6 publications

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“…Three case reports/case series and two transplantation registries found no abnormal outcomes ( Moskovitz et al , 1988 ; Holmgren et al , 2004 ; Xu et al , 2009 ; Ecevit et al , 2012 ; Moritz et al , 2017 ; Schopf, 2017 ). A population-based registry found a higher risk of birth defects although this was not statistically significant ( Egeberg et al , 2017 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review

Perez-Garcia

Dolhain

Vorstenbosch

et al. 2020

Human Reproduction Update

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BACKGROUND Information regarding the possible influence of immunosuppressive drugs on male sexual function and reproductive outcomes is scarce. Men diagnosed with immune-mediated diseases and a wish to become a father represent an important neglected population since they lack vital information to make balanced decisions about their treatment. OBJECTIVE AND RATIONALE The aim of this research was to systematically review the literature for the influence of paternal immunosuppressive drug use on many aspects of male sexual health, such as sexual function, fertility, pregnancy outcomes and offspring health outcomes. SEARCH METHODS A systematic literature search was performed in the bibliographic databases: Embase (via Elsevier embase.com), MEDLINE ALL via Ovid, Cochrane Central Register of Trials (via Wiley) and Web of Science Core Collection. Additionally, Google Scholar and the Clinical trial registries of Europe and the USA were searched. The databases were searched from inception until 31 August 2019. The searches combined keywords regarding male sexual function and fertility, pregnancy outcomes and offspring health with a list of immunosuppressive drugs. Studies were included if they were published in English and if they included original data on male human exposure to immunosuppressive drugs. A meta-analysis was not possible to perform due to the heterogeneity of the data. OUTCOMES A total of 5867 references were identified, amongst which we identified 161 articles fulfilling the eligibility criteria. Amongst these articles, 50 included pregnancy and offspring outcomes and 130 included sexual health outcomes. Except for large Scandinavian cohorts, most of the identified articles included a small number of participants. While a clear negative effect on sperm quality was evident for sulfasalazine and cyclophosphamide, a dubious effect was identified for colchicine, methotrexate and sirolimus. In three articles, exposure to tumour necrosis factor-α inhibitors in patients diagnosed with ankylosing spondylitis resulted in improved sperm quality. The information regarding pregnancy and offspring outcomes was scant but no large negative effect associated with paternal immunosuppressive drug exposure was reported. WIDER IMPLICATIONS Evidence regarding the safety of immunosuppressive drugs in men with a wish to become a father is inconclusive. The lack of standardisation on how to evaluate and report male sexual function, fertility and reproduction as study outcomes in men exposed to immunosuppressive drugs is an important contributor to this result. Future research on this topic is needed and should be preferably done using standardised methods.

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Section: Discussionmentioning

confidence: 99%

The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review

Perez-Garcia

Dolhain

Vorstenbosch

et al. 2020

Human Reproduction Update

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“…O mecanismo dessas alterações não está esclarecido. Um outro estudo avaliou o efeito inibitório do diclofenaco sódico na síntese de prostaglandinas sobre a espermatogênese de pacientes com oligospermia (50) . O diclofenaco sódico foi administrado na dose de 100 mg, via oral, diariamente, por 30 dias.…”

Section: Antiinflamatórios Não-esteroidaisunclassified

Doenças reumáticas e infertilidade masculina

Freire¹,

Nepomuceno²,

Maia³

et al. 2006

Rev. Bras. Reumatol.

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artigo dE rEvisão rEviEw articlE RESUMO As doenças reumáticas podem causar distúrbios sexuais e reprodutivos. As razões destes distúrbios são multifatoriais. Manifestações e sintomas das doenças podem reduzir a libido e interferir no sucesso da reprodução, como ocorre na artrite reumatóide (AR), lúpus eritematoso sistêmico (LES), espondilite anquilosante (EA) e esclerose sistêmica (ES). A atividade da doença pode levar a uma alteração do eixo hipotálamo-hipófise, acarretando períodos de disfunção gonadal. Os auto-anticorpos e os distúrbios de hormônios sexuais, que podem estar presentes em muitas doenças reumáticas, podem influenciar negativamente na fertilidade. Além disso, algumas drogas usadas no tratamento de doenças reumatológicas por vezes representam um risco para a reprodução masculina, devido aos efeitos adversos que podem causar, como defeitos cromossômicos e gonadotoxicidade, prejudicando a espermatogênese e a motilidade dos espermatozóides. Conseqüentemente, há falência gonadal transitória ou permanente. Este trabalho faz uma revisão de um assunto pouco abordado na literatura brasileira.

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“…Des ~tudes non contr61~es ont montr~ un effet b~n~fique des anti-inflammatoires en cas d'oligospermie [32]. Cependant l'am~lio-ration rapide (3 semaines) obtenue chez nos patients sugg~re que le diclofenac a agi sur une possible composante obstructive.…”

Section: E) Traitement Par Le Diclofdnacunclassified

Etiologic factors of male sterility evaluated in 350 men — efficiency of treatments

Pan

Campana

1997

Androl.

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Effect of Diclofenac Sodium (Voltaren) on Spermatogenesis of Infertile Oligospermic Patients

Cited by 14 publications

References 6 publications

The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review

The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review

Doenças reumáticas e infertilidade masculina

Etiologic factors of male sterility evaluated in 350 men — efficiency of treatments

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