Effect of diesel exhaust particles on renal vascular responses in rats with chronic kidney disease

Suleimani, Yousuf M. Al; Mahruqi, A S Al; Za’abi, Mohammed Al; Shalaby, Asem; Ashique, Mohammed; Nemmar, Abderrahim; Ali, Badreldin H.

doi:10.1002/tox.22258

Cited by 62 publications

(38 citation statements)

References 22 publications

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“…Single-cell suspensions of the different lungs, hearts, livers, kidneys, spleens, and brains were obtained and analyzed according to the method described in our previous publications [27–30]. …”

Section: Methodsmentioning

confidence: 99%

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Nemmar

Yuvaraju

Beegam

et al. 2017

Oxidative Medicine and Cellular Longevity

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CeO2 nanoparticles (CeO2 NPs) which are used as a diesel fuel additive are emitted in the particulate phase in the exhaust, posing a health concern. However, limited information exists regarding the in vivo acute toxicity of CeO2 NPs on multiple organs. Presently, we investigated the acute (24 h) effects of intratracheally instilled CeO2 NPs in mice (0.5 mg/kg) on oxidative stress, inflammation, and DNA damage in major organs including lung, heart, liver, kidneys, spleen, and brain. Lipid peroxidation measured by malondialdehyde production was increased in the lungs only, and reactive oxygen species were increased in the lung, heart, kidney, and brain. Superoxide dismutase activity was decreased in the lung, liver, and kidney, whereas glutathione increased in lung but it decreased in the kidney. Total nitric oxide was increased in the lung and spleen but it decreased in the heart. Tumour necrosis factor-α increased in all organs studied. Interleukin- (IL-) 6 increased in the lung, heart, liver, kidney, and spleen. IL-1β augmented in the lung, heart, kidney, and spleen. Moreover, CeO2 NPs induced DNA damage, assessed by COMET assay, in all organs studied. Collectively, these findings indicate that pulmonary exposure to CeO2 NPs causes oxidative stress, inflammation, and DNA damage in multiple organs.

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Section: Methodsmentioning

confidence: 99%

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Nemmar

Yuvaraju

Beegam

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…The plasma concentrations of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL -6), interleukin 1β (IL -1β), adiponectin, and sclerostin were measured by ELISA methods, as detailed elsewhere [18, 32]. …”

Section: Methodsmentioning

confidence: 99%

“…The supernatants of renal homogenates were separated and used for the measurement of total protein, catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as described earlier [18, 32]. …”

Section: Methodsmentioning

confidence: 99%

The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon

et al. 2017

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Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents’ curcumin or lisinopril might offer additional nephroprotection.

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“…These include impaired renal blood flow and an increased incidence of renal disease (183,184), exacerbation of metabolic syndrome/diabetes (185–188), changes to the placental circulation (189–191) and epigenetic alterations that may affect the cardiorespiratory health of offspring (192,193). …”

Section: Role Of Oxidative Stress In the Cardiovascular Effects Of Aimentioning

confidence: 99%

Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution

Niemann

Rohrbach

Miller

et al. 2017

Journal of the American College of Cardiology

281

177

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Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress, namely diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting. Here, we explore the role of different ROS sources arising in obesity and diabetes, and the impact of excessive ROS production on the development of cardiac lipotoxicity. In parallel, contaminants in the air that we breathe pose a significant threat to human health. This paper provides an overview of cigarette smoke and urban air pollution, considering how their composition and biological effects have detrimental effects on cardiovascular health.

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Effect of diesel exhaust particles on renal vascular responses in rats with chronic kidney disease

Cited by 62 publications

References 22 publications

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon

Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution

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