Effect of diet and genotype on the miRNome of mice with altered lipoprotein metabolism

Busnelli, Marco; Manzini, Stefano; Colombo, Alice; Franchi, Elsa; Chiara, Matteo; Zaffaroni, Gaia; Horner, David; Chiesa, Giulia

doi:10.1016/j.isci.2023.107615

Cited by 2 publications

(2 citation statements)

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“…They found that a Western diet led to a rise in body weight and cholesterol levels in both Ldlr-KO and C57Bl/6 mice, however, atherosclerosis was considerably higher in Ldlr-KO mice exclusively. 148 The genetic background is equally important, and has a great impact on the metabolic disturbances caused by dietary interventions. This also occurs in genetic models (ob/ob) and mixed models, including genetic plus dietary models (foz/foz + HFD).…”

Section: Diethylnitrosamine Model (Den)mentioning

confidence: 99%

“…investigated the effect of both diet and genotype on the miRNome of mice with altered lipoprotein metabolism. They found that a Western diet led to a rise in body weight and cholesterol levels in both Ldlr‐KO and C57Bl/6 mice, however, atherosclerosis was considerably higher in Ldlr‐KO mice exclusively 148 . The genetic background is equally important, and has a great impact on the metabolic disturbances caused by dietary interventions.…”

Section: Other Additional Factors To Considermentioning

confidence: 99%

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Novel insights into metabolic‐associated steatotic liver disease preclinical models

Montero‐Vallejo,

Maya‐Miles,

Ampuero

et al. 2024

Liver International

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Metabolic‐associated steatotic liver disease (MASLD) encompasses a wide spectrum of metabolic conditions associated with an excess of fat accumulation in the liver, ranging from simple hepatic steatosis to cirrhosis and hepatocellular carcinoma. Finding appropriate tools to study its development and progression is essential to address essential unmet therapeutic and staging needs. This review discusses advantages and shortcomings of different dietary, chemical and genetic factors that can be used to mimic this disease and its progression in mice from a hepatic and metabolic point of view. Also, this review will highlight some additional factors and considerations that could have a strong impact on the outcomes of our model to end up providing recommendations and a checklist to facilitate the selection of the appropriate MASLD preclinical model based on clinical aims.

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Section: Diethylnitrosamine Model (Den)mentioning

confidence: 99%

Section: Other Additional Factors To Considermentioning

confidence: 99%