Effect of diet and gut environment on the gastrointestinal formation of N -nitroso compounds: A review

Kobayashi, Jun

doi:10.1016/j.niox.2017.06.001

Cited by 95 publications

(80 citation statements)

References 83 publications

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“…amounts of NO are already being generated by macrophage iNOS, causing nitrosative stress there. In fact, increased NO in exhaled air has been detected following a nitrate-rich meal, 18) although this exhaled NO is not derived from alveolar levels in the lung, but from upper airways including the nasal airways, 17,19) suggesting that dietary nitrite-mediated molecules do not reflect NO production at the alveolar level. This raises the question as to what kind of nitrite-mediated molecules could contribute to the beneficial effect following dietary nitrite?…”

Section: Nitrite and Nitrate Concentrations In The Plasmamentioning

confidence: 99%

Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model

Sonoda

Ohtake

Tagiri

et al. 2018

Biological & Pharmaceutical Bulletin

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Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via antiinflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Dietary nitrite dose-dependently (50 and 150 mg/L in drinking water) attenuated emphysematous development and macrophage accumulation in the alveolar parenchyma 21 d after PPE treatment. The present study shows that dietary nitrite might be a possible nutritional strategy in preventing the development of PE in mice.

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Section: Nitrite and Nitrate Concentrations In The Plasmamentioning

confidence: 99%

Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model

Sonoda

Ohtake

Tagiri

et al. 2018

Biological & Pharmaceutical Bulletin

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“…There are some theories behind this observation. First, chronic watery diarrhea reduces the transit time in the colon, thus, resulting in less exposure to potentially harmful toxic agents [30]. Second, Yen et al [19] suggested that an increased amount of intraepithelial lymphocytes in the colonic mucosa recruit d-gamma T-cells to the colonic mucosa, which are involved in killing cells with a damaged DNA.…”

Section: Discussionmentioning

confidence: 99%

Microscopic colitis and its associations with complications observed in classic inflammatory bowel disease: a systematic review

Solberg

Ohlsson

2020

Scandinavian Journal of Gastroenterology

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Objectives: Crohn's disease and ulcerative colitis are associated with an increased risk to develop anemia, cutaneous diseases, liver diseases, malignancy, osteoporosis, rheumatic diseases, thromboembolism and uveitis. The association between these diseases and microscopic colitis (MC) is not known. The aim of the present systematic review was to examine associations between MC and diseases observed in association with Crohn's disease and ulcerative colitis. Material and methods: According to the review protocol, original articles which described the prevalence of abovementioned diseases in relation to MC, were searched for in PubMed, Embase and Web of Science. Results: After exclusion of duplicates, 928 articles remained. Based on relevancy of their title, abstract or type of article, 16 articles were ordered in full text and after assessment, nine articles could be included in the review. A second research strategy with individual diseases rendered further two articles. Seven articles covered malignancy/neoplasia, where four showed no association with malignancy and three a reduced association compared with controls. Four articles covering rheumatic diseases showed an association between these diseases and MC. One study showed an association between MC and osteoporosis, whereas one did not. One study showed an association between MC and cutaneous diseases, whereas anemia, eye diseases and thromboembolism showed no associations. Conclusions: Due to short follow-up time in small studies, with selection bias due to exclusion of former or prevalent malignancy in an older population, no conclusions can be drawn concerning the true association between MC and malignancy. Rheumatic diseases seem to be associated with MC.

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“…The induction of cell toxicity and proliferation by heme iron‐triggered lipid oxidation and the formation of genotoxic HCAs and PAHs during heating and smoking of meat . Indeed, added nitrates and nitrites could be precursors of NOC due to chemical reactions with the amine groups of meat proteins in the human gastrointestinal tract, so the potential carcinogens are formed in the body after ingestion of the meat …”

Section: Discussionmentioning

confidence: 99%

“…14 Indeed, added nitrates and nitrites could be precursors of NOC due to chemical reactions with the amine groups of meat proteins in the human gastrointestinal tract, so the potential carcinogens are formed in the body after ingestion of the meat. 40 A number of studies concluded that the consumption of poultry decreased the risk of CRC. 24,26,33 In contrast, other studies/meta-analysis are showing no significant association between white meat consumption and CRC risk.…”

Section: Discussionmentioning

confidence: 99%

Consumption of meat, traditional and modern processed meat and colorectal cancer risk among the Moroccan population: A large‐scale case–control study

Deoula

Kinany

Huybrechts

et al. 2019

Intl Journal of Cancer

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The current study aimed to investigate the relationship between red and white meat subtypes, processed meat (divided into traditional “Khlii, Kaddid” and industrially processed meat) and colorectal cancer (CRC) risk, considering CRC subsites, in Moroccan adults. A case–control study was conducted including 2,906 matched case–control pairs recruited from the five largest university hospitals in Morocco. Dietary data were collected through a validated Food Frequency Questionnaire (FFQ). Multivariable odds ratios (OR) and 95% confidence intervals (CI), for the association of CRC risk with meat consumption (high vs. low intake), were estimated using conditional logistic regression models, adjusted for relevant confounding variables. Overall, consumption of red meat was positively associated with colon cancer and CRC risk (OR = 1.23, 95% CI = 1.05–1.44; OR = 1.14, 95% CI = 1.02–1.27), respectively. In contrast, no significant association was observed between the consumption of red meat and rectal cancer risk (OR = 1.05, 95% = 0.90–1.23). Interestingly, while processed meat from industrial processes was positively associated with colon cancer, rectal cancer and CRC (OR = 1.61, 95% CI = 1.27–2.04; OR = 1.73, 95% CI = 1.34–2.23; OR = 1.67, 95% CI = 1.41–1.98), processed meat prepared using traditional methods was inversely associated with colon cancer and CRC risk (OR = 0.74, 95% CI = 0.57–0.98; OR = 0.77, 95% CI = 0.64–0.93), respectively. Furthermore, positive associations were observed between poultry intake and colon cancer risk among men (OR = 1.27, 95% CI = 1.01–1.59). Our study showed similar associations between the consumption of red meat and CRC risk in Morocco as in developed countries, while inverse associations were found for traditionally processed meat products. This is the first study to investigate the differential effects of traditional vs. westernized processed meat products in a developing country. Other studies are needed to confirm these findings and to understand the physiological pathways underlying these associations.

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Effect of diet and gut environment on the gastrointestinal formation of N -nitroso compounds: A review

Cited by 95 publications

References 83 publications

Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model

Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model

Microscopic colitis and its associations with complications observed in classic inflammatory bowel disease: a systematic review

Consumption of meat, traditional and modern processed meat and colorectal cancer risk among the Moroccan population: A large‐scale case–control study

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