Effect of diet and individual dietary guidance on gastrointestinal endocrine cells in patients with irritable bowel syndrome (Review)

Mazzawi, Tarek

doi:10.3892/ijmm.2017.3096

Cited by 22 publications

(22 citation statements)

References 171 publications

(207 reference statements)

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“…This common functional disorder has significant impacts on patients’ quality of life as well as increases enormous economic burdens of on healthcare systems [ 1 , 2 ]. IBS patients suffer from various ranges of symptoms, including abdominal pain/discomfort, abdominal bloating, and alteration in the bowel habits [ 3 ]. While the pathophysiology of IBS is not well understood, the interplay between diet and the gut microbiota has gained interest in recent years [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

Barandouzi

Lee

Maas

et al. 2021

JPM

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The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.

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Section: Introductionmentioning

confidence: 99%

Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

Barandouzi

Lee

Maas

et al. 2021

JPM

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“…Interactions of the above-mentioned contributing factors with each other have certain effects on the gut-brain axis that may contribute to the development of symptoms related to the gastrointestinal [9,10] and nervous [11,12] systems. Previous publications have shown the effect of dietary changes on the symptoms [1,[13][14][15][16], gut microbiota [17,18], and enteroendocrine cells [19][20][21] in IBS patients. In addition, changing the composition of the gut microbiota through fecal microbiota transplantation (FMT) had a positive clinical outcome not only in cases of Clostridium difficile [22,23] but also in IBS [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Uroguanylin Immunoreactive Cells Density in the Duodenum of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Changes following Fecal Microbiota Transplantation

Mazzawi

Eikrem

Lied

et al. 2020

Gastroenterology Research and Practice

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Altered densities of enteroendocrine cells play an important role in patients with irritable bowel syndrome (IBS). Uroguanylin activates guanylate cyclase-C to regulate intestinal electrolyte and water transport. Aim. To quantify uroguanylin immunoreactive cells density in the duodenum of diarrhea-predominant IBS (IBS-D) patients compared to controls and to investigate the effect of fecal microbiota transplantation (FMT) on these cell densities. Method. Twelve patients with IBS-D according to Rome III criteria were included. The cause was identified as post infectious (PI, n=6) or idiopathic (n=6). They completed the IBS-symptom questionnaire before and 3 weeks after FMT. Thirty grams of fresh feces donated from healthy relatives were diluted with 60 ml normal saline and instilled via endoscope into the duodenum. Biopsies were taken from the patients’ duodenum before and 3 weeks after FMT. Duodenal biopsies taken from eight healthy controls were also included. The biopsies were immunostained for uroguanylin and quantified using computerized image analysis. Results. Uroguanylin immunoreactive cells were found both in duodenal villi and crypts in both controls and IBS-D patients. The densities of uroguanylin immunoreactive cells were significantly lower in the villi (P<0.0001) and higher in the crypts (P<0.0001) for the patients than the controls. Following FMT, the densities of uroguanylin immunoreactive cells for the total group and idiopathic subgroup decreased significantly in the duodenal crypts (P=0.049 and 0.04, respectively) but not in the villi. No significant changes were shown in the PI-IBS subgroups. The cells density in only the crypts correlated with diarrhea (r=0.97, P=0.001) and bloating (r=–0.91, P=0.01) in the PI-IBS subgroup before FMT and with abdominal pain (r=0.63, P=0.03) in the total group of IBS-D patients after FMT. Conclusion. Altered uroguanylin immunoreactive cells density was found in IBS-D patients compared to controls. Changes in these cells density following FMT correlated with IBS symptoms (diarrhea, bloating, and abdominal pain).

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“…In turn, this aggregation of fluids and gases results in visceral hypersensitivity, gut microflora alterations, and changes in intestinal hormones and neurotransmitters that characterize IBS ( 65 ). There are ∼15 different types of gastrointestinal endocrine cells releasing different types of hormones depending on the types of sensed nutrients ( 66 ). The interactions between FODMAPs and gastrointestinal endocrine cells induce changes in cell densities.…”

Section: Methodsmentioning

confidence: 99%

Non-Celiac Gluten Sensitivity and Irritable Bowel Disease: Looking for the Culprits

Koumbi

Γιουλεμέ

Vassilopoulou

2020

Current Developments in Nutrition

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During the last 30 y, a gluten-free diet has been classified among the most popular fad diets mainly due to the ambiguous notion that gluten avoidance promotes health. Gluten intolerance has been implicated in non-celiac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS), 2 disorders with overlapping symptoms and increasing trend. Together with gluten, other wheat components; fermentable oligo-, di-, monosaccharide, and polyols (FODMAPs); and amylase trypsin inhibitors (ATIs), are implicated in the pathogenesis of both disorders. Gut microflora alterations in IBS and NCGS have been described, while microbiota manipulations have been shown to be promising in some IBS cases. This literature review summarizes our current knowledge on the impact of wheat ingredients (gluten, FODMAPs, and ATIs) in IBS and NCGS. In both disorders, FODMAPs and ATIs trigger gut dysbiosis, suggesting that gluten may not be the culprit, and microbiota manipulations can be applied in diagnostic and intervention approaches.

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Effect of diet and individual dietary guidance on gastrointestinal endocrine cells in patients with irritable bowel syndrome (Review)

Cited by 22 publications

References 171 publications

Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

Abnormal Uroguanylin Immunoreactive Cells Density in the Duodenum of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Changes following Fecal Microbiota Transplantation

Non-Celiac Gluten Sensitivity and Irritable Bowel Disease: Looking for the Culprits

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