Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials

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doi:10.1136/bmj.j3119

Cited by 268 publications

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“…The findings were consistent when continuous covariates were further analysed as categorical values (Table 11). 1 This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.…”

Section: Differential Effects Of the Intervention For Composite Matermentioning

confidence: 99%

Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation

Rogozińska

Marlin

Jackson

et al. 2017

Health Technol Assess

235

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BackgroundDiet- and physical activity-based interventions in pregnancy have the potential to alter maternal and child outcomes.ObjectivesTo assess whether or not the effects of diet and lifestyle interventions vary in subgroups of women, based on maternal body mass index (BMI), age, parity, Caucasian ethnicity and underlying medical condition(s), by undertaking an individual patient data (IPD) meta-analysis. We also evaluated the association of gestational weight gain (GWG) with adverse pregnancy outcomes and assessed the cost-effectiveness of the interventions.Data sourcesMEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects and Health Technology Assessment database were searched from October 2013 to March 2015 (to update a previous search).Review methodsResearchers from the International Weight Management in Pregnancy Collaborative Network shared the primary data. For each intervention type and outcome, we performed a two-step IPD random-effects meta-analysis, for all women (except underweight) combined and for each subgroup of interest, to obtain summary estimates of effects and 95% confidence intervals (CIs), and synthesised the differences in effects between subgroups. In the first stage, we fitted a linear regression adjusted for baseline (for continuous outcomes) or a logistic regression model (for binary outcomes) in each study separately; estimates were combined across studies using random-effects meta-analysis models. We quantified the relationship between weight gain and complications, and undertook a decision-analytic model-based economic evaluation to assess the cost-effectiveness of the interventions.ResultsDiet and lifestyle interventions reduced GWG by an average of 0.70 kg (95% CI –0.92 to –0.48 kg; 33 studies, 9320 women). The effects on composite maternal outcome [summary odds ratio (OR) 0.90, 95% CI 0.79 to 1.03; 24 studies, 8852 women] and composite fetal/neonatal outcome (summary OR 0.94, 95% CI 0.83 to 1.08; 18 studies, 7981 women) were not significant. The effect did not vary with baseline BMI, age, ethnicity, parity or underlying medical conditions for GWG, and composite maternal and fetal outcomes. Lifestyle interventions reduce Caesarean sections (OR 0.91, 95% CI 0.83 to 0.99), but not other individual maternal outcomes such as gestational diabetes mellitus (OR 0.89, 95% CI 0.72 to 1.10), pre-eclampsia or pregnancy-induced hypertension (OR 0.95, 95% CI 0.78 to 1.16) and preterm birth (OR 0.94, 95% CI 0.78 to 1.13). There was no significant effect on fetal outcomes. The interventions were not cost-effective. GWG, including adherence to the Institute of Medicine-recommended targets, was not associated with a reduction in complications. Predictors of GWG were maternal age (summary estimate –0.10 kg, 95% CI –0.14 to –0.06 kg) and multiparity (summary estimate –0.73 kg, 95% CI –1.24 to –0.23 kg).LimitationsThe findings were limited by the lack of standardisation in the components of intervention, residual heterogeneity in effects across studies for most analyses and the unavailability of IPD in some studies.ConclusionDiet and lifestyle interventions in pregnancy are clinically effective in reducing GWG irrespective of risk factors, with no effects on composite maternal and fetal outcomes.Future workThe differential effects of lifestyle interventions on individual pregnancy outcomes need evaluation.Study registrationThis study is registered as PROSPERO CRD42013003804.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Section: Differential Effects Of the Intervention For Composite Matermentioning

confidence: 99%

Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation

Rogozińska

Marlin

Jackson

et al. 2017

Health Technol Assess

235

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“…The US Institute of Medicine (IOM) developed GWG guidelines in 1990 and updated them in 2009 (Table 1), yet nearly three quarters of women now gain weight outside these guidelines [4, 5]. Given that lifestyle intervention improves outcomes, meeting GWG guidelines is an important target [6]. However, the IOM guidelines are based on data from primarily USA-dwelling, Caucasian and Black women, with limited ethnic diversity that may not be applicable to women from Europe and Asia.…”

Section: Introductionmentioning

confidence: 99%

Gestational weight gain across continents and ethnicity: systematic review and meta-analysis of maternal and infant outcomes in more than one million women

Goldstein

Abell

Ranasinha

et al. 2018

BMC Med

356

334

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BackgroundThe association between Institute of Medicine (IOM) guidelines and pregnancy outcomes across ethnicities is uncertain. We evaluated the associations of gestational weight gain (GWG) outside 2009 IOM guidelines, with maternal and infant outcomes across the USA, western Europe and east Asia, with subgroup analyses in Asia. The aim was to explore ethnic differences in maternal prepregnancy body mass index (BMI), GWG and health outcomes across these regions.MethodsSystematic review, meta-analysis and meta-regression of observational studies were used for the study. MEDLINE, MEDLINE In-Process, Embase and all Evidence-Based Medicine (EBM) Reviews were searched from 1999 to 2017. Studies were stratified by prepregnancy BMI category and total pregnancy GWG. Odds ratio (ORs) 95% confidence intervals (CI) applied recommended GWG within each BMI category as the reference. Primary outcomes were small for gestational age (SGA), preterm birth and large for gestational age (LGA). Secondary outcomes were macrosomia, caesarean section and gestational diabetes.ResultsOverall, 5874 studies were identified and 23 were included (n = 1,309,136). Prepregnancy overweight/obesity in the USA, Europe and Asia was measured at 42%, 30% and 10% respectively, with underweight 5%, 3% and 17%. GWG below guidelines in the USA, Europe and Asia was 21%, 18% and 31%, and above was 51%, 51% and 37% respectively. Applying regional BMI categories in Asia showed GWG above guidelines (51%) was similar to that in the USA and Europe.GWG below guidelines was associated with a higher risk of SGA (USA/Europe [OR 1.51; CI 1.39, 1.63]; Asia [1.63; 1.45, 1.82]) and preterm birth (USA/Europe [1.35; 1.17, 1.56]; Asia [1.06; 0.78, 1.44]) than GWG within guidelines. GWG above guidelines was associated with a higher risk of LGA (USA/Europe [1.93; 1.81, 2.06]; Asia [1.68; 1.51 , 1.87]), macrosomia (USA/Europe [1.87; 1.70, 2.06]; Asia [2.18; 1.91, 2.49]) and caesarean (USA/Europe [1.26; 1.21, 1.33]; Asia [1.37; 1.30, 1.45]). Risks remained elevated when regional BMI categories were applied for GWG recommendations. More women in Asia were categorised as having GWG below guidelines using World Health Organization (WHO) (60%) compared to regional BMI categories (16%), yet WHO BMI was not accompanied by increased risks of adverse outcomes.ConclusionsWomen in the USA and western Europe have higher prepregnancy BMI and higher rates of GWG above guidelines than women in east Asia. However, when using regional BMI categories in east Asia, rates of GWG above guidelines are similar across the three continents. GWG outside guidelines is associated with adverse outcomes across all regions. If regional BMI categories are used in east Asia, IOM guidelines are applicable in the USA, western Europe and east Asia.Electronic supplementary materialThe online version of this article (10.1186/s12916-018-1128-1) contains supplementary material, which is available to authorized users.

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“…Intervenções baseadas em atividade física associada à dieta resultam em ganho de peso significativamente menor durante a gestação. Além disso, o hábito associa-se de modo relevante à redução da ocorrência de diabetes mellitus gestacional (10) . Desse modo, a correta orientação e o estímulo à prática de atividade física podem ser favoráveis à saúde dessas mulheres.…”

Section: Discussionunclassified

Determinantes sociais da saúde de gestantes acompanhadas no pré-natal de alto risco

et al. 2020

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Determinantes sociais da saúde de gestantes acompanhadas no prénatal de alto riscoSocial determinants of health of high-risk pregnant women during prenatal follow-up RESUMO Objetivo: avaliar os determinantes sociais da saúde de gestantes acompanhadas no pré-natal de alto risco. Métodos: estudo observacional e transversal, realizado com 276 gestantes de alto risco. A coleta deu-se mediante aplicação de questionário estruturado acerca dos determinantes sociais da saúde, além de dados clínicos e obstétricos das mulheres. Os dados foram analisados através do programa estatístico Jamovi®, versão 0.9, e discutidos segundo o Modelo de Dahlgren e Whitehead. Resultados: as condições individuais; o comportamento e estilo de vida; a rede social e comunitária; e a condição de vida, tais como: trabalho, saúde, educação, saneamento básico e habitação podem constituir fator de risco ou de proteção à saúde da gestante. Conclusão: determinantes como idade, raça, tipo de gestação, nível educacional, a situação de moradia e o acesso aos serviços de saúde foram considerados favoráveis à saúde da maioria das gestantes, porém, a prevalência de gravidez não planejada como comportamento desfavorável. ABSTRACT Objective: to evaluate the social determinants of health of high-risk pregnant women during prenatal follow-up. Methods: observational and cross-sectional study with 276 high-risk pregnant women. Data were collected by applying a structured questionnaire about the social determinants of health, as well as clinical and obstetric data from highrisk pregnant women. Data were analyzed using the Jamovi® statistical software, version 0.9, and discussed according to the Dahlgren and Whitehead's Model. Results: individual conditions; behavior and lifestyle; social and community network; and the condition of life, such as work, health, education, sanitation and housing may constitute a risk or health protection factor for pregnant women. Conclusion: determinants such as age, race, type of pregnancy, educational level, housing situation and access to health services were considered favorable to the health of most pregnant women, but the prevalence of unplanned pregnancy as unfavorable behavior.

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Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials

Cited by 268 publications

References 116 publications

Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation

Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation

Gestational weight gain across continents and ethnicity: systematic review and meta-analysis of maternal and infant outcomes in more than one million women

Determinantes sociais da saúde de gestantes acompanhadas no pré-natal de alto risco

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