Effect of Diet on Experimental Pancreatitis in Rat

Maki, Tetsuo; Kakizaki, G; Sato, Toshio; Saito, Yoichi; Suda, Yasuo; Onuma, Toshiyuki; Hayasaka, Noriyoshi

doi:10.1620/tjem.92.301

Cited by 17 publications

(6 citation statements)

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“…47 Animal models document associations with high protein and fat diets in the development of AP. [48][49][50][51] Further potential evidence for the role of high-fat diets in the development of AP comes from the results of a study evaluating ketogenic diets in the management of idiopathic epilepsy. 3 In that study 3/9 dogs fed a ketogenic diet (57% fat, 5.8% NFE, 25% crude protein; as dry matter) developed pancreatitis whereas only 2/31 dogs fed the control diet (16% crude fat, 54% NFE, 25% crude protein; as dry matter) developed pancreatitis.…”

Section: Dietary Factorsmentioning

confidence: 99%

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Cridge

Lim

Algül

et al. 2022

Veterinary Internal Medicne

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While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors for pancreatitis in dogs, allowing for improved awareness and detection of potential dog‐specific risk factors, which might guide the development of disease prevention strategies. Additionally, we review important advances in our understanding of the pathophysiology of pancreatitis and potential areas for therapeutic manipulation based thereof. The outcome of pathophysiologic mechanisms and the development of clinical disease is dependent on the balance between stressors and protective mechanisms, which can be evaluated using the critical threshold theory.

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Section: Dietary Factorsmentioning

confidence: 99%

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Cridge

Lim

Algül

et al. 2022

Veterinary Internal Medicne

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“…It has been consistently shown that high protein and fat diets potentiate the severity of experimentally-induced AP in animals. [1–31819] Contrary to the above studies, Sarles et al . [48] found that the administration of different diets to rats fed on ethanol produced changes in the pancreas no different to those fed on water.…”

Section: Discussionmentioning

confidence: 96%

“…This suggests a role for diet in the development of AP, a role that has been investigated in animal models[1–3] as well as in humans. [4–6] On the other hand, lack of nutrition as well as malnutrition have also been linked to the development of AP.…”

mentioning

confidence: 99%

Systematic review of diet in the pathogenesis of acute pancreatitis: A tale of too much or too little?

Thomas

Mah

Barreto

2012

Saudi J Gastroenterol

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Background/Aim:The role of diet as the cause of acute pancreatitis (AP) has been suggested. The aim of the current review was to determine if there exists sufficient evidence linking nutrition, or the lack of it, to the pathogenesis of AP.Patients and Methods:A systematic search of the scientific literature was carried out using Embase, PubMed, MEDLINE, and the Cochrane Central Register of Controlled Trials for the years 1965 - 2011 to obtain access to studies involving dietary factors and the pathogenesis of AP.Results:A total of 17 studies were identified describing diet and AP. These included 12 human and 5 animal studies. 8 reports were found to link malnutrition and/or refeeding to the pathogenesis of AP. Two studies found an increased consumption of fats and proteins in patients with alcohol-related AP while 1 study noted a lesser intake of carbohydrate in patients. However, none of these differences attained statistical significance. A recent prospective case-control study found a significantly higher risk for AP amongst patients eating par-boiled rice and fresh water fish.Conclusions:Evidence from literature does not appear to support the role of diet as a single bolus meal as a cause for AP. Prolonged consumption of diets rich in proteins and fats may work synergistically with gallstones / alcohol to trigger an attack of AP indicating a possible role of diet as a cofactor in the development of AP possibly by lowering the threshold needed by these other agents to lead to the attack of AP.

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“…This is in agreement with Maki's work. 4 Another report showed a divergent result; namely that experimental acute pancreatitis was most severe in dogs that had been fed a high fat diet.3 It is worth noting that although the induction methods and animals were different in these two papers, high fat and high protein diets intensified acute pancreatitis in each case.…”

Section: Discussionmentioning

confidence: 99%

Antecedent long term ethanol consumption in combination with different diets alters the severity of experimental acute pancreatitis in rats.

Rämö¹

1987

Gut

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Effect of Diet on Experimental Pancreatitis in Rat

Cited by 17 publications

References 0 publications

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Systematic review of diet in the pathogenesis of acute pancreatitis: A tale of too much or too little?

Antecedent long term ethanol consumption in combination with different diets alters the severity of experimental acute pancreatitis in rats.

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