Effect of Diet on Term Infant Cerebral Cortex Fatty Acid Composition

Jamieson, E.Cherry; Abbasi, Kanwal; Cockburn, F.; Farquharson, James; Logan, R. W.; Patrick, W A

doi:10.1159/000423568

Cited by 16 publications

(8 citation statements)

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“…114 These forces include settling; short-term, low-speed centrifugation; high-speed centrifugation; and precipitation by micelle-destroying treatments, such as using the enzyme rennin (chymosin) or reducing the pH. 114 These forces include settling; short-term, low-speed centrifugation; high-speed centrifugation; and precipitation by micelle-destroying treatments, such as using the enzyme rennin (chymosin) or reducing the pH.…”

Section: Watermentioning

confidence: 99%

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Biochemistry of Human Milk

Lawrence

2011

Breastfeeding

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Section: Watermentioning

confidence: 99%

“…114 After birth, neuronal membranes and retinal photoreceptor cells derive most of their phospholipid DHA from diet and liver synthesis and not from fat reserves. 114 After birth, neuronal membranes and retinal photoreceptor cells derive most of their phospholipid DHA from diet and liver synthesis and not from fat reserves.…”

Section: Brain Developmentmentioning

confidence: 99%

Biochemistry of Human Milk

Lawrence

2011

Breastfeeding

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“…It has been observed before that breast feeding is associated with better cognitive performance but the mechanism is unclear. However, n-3 and n-6 LC-PUFAs are important components of the cell membranes and, therefore, essential in the formation of new tissue, including neurons and glial cells [ 19 , 20 ]. In addition, PUFA may have a neuroprotective role, making nervous tissue less susceptible to damage [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Fatty acid composition in breastfeeding and school performance in children aged 12 years

et al. 2015

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PurposeBreastfeeding has been associated with improved cognition. It remains unclear whether long-chain polyunsaturated fatty acids (LC-PUFAs) play a role in this association. We assessed the association between LC-PUFA concentrations in infant feeding and school performance at age 12.MethodsWithin a population-based birth cohort, we compared school performance of 277 non-breastfed children and 157 children who had fatty acid composition of their mothers’ breast milk measured. Two indicators of school performance were: (1) the score on a standardized achievement test and (2) the teacher’s advice regarding a child’s potential performance level in secondary education. Linear regression and multinomial logistic regression analyses were performed to assess the independent association between LC-PUFA content of breast milk and school performance.ResultsGirls, who received breast milk with a relative high content (above the median) of docosahexaenoic acid (DHA), had a higher Cito-test score (β = 2.96 points, 95 % CI 0.24; 5.69) than non-breastfed girls. Among the breastfed girls, each percentage point of higher content of total n-3 LC-PUFA (β = 4.55, 95 % CI 0.43; 8.66) and DHA (β = 7.09, 95 % CI 0.9; 13.3) was associated with a higher Cito-test score. The association between LC-PUFA content and teacher school advice showed a similar pattern. There was no association between LC-PUFA content and school performance in boys.ConclusionAlthough a large part of the association between infant milk feeding and cognition seems to be explained by sociodemographic and lifestyle-related factors, a relative high content of n-3 PUFAs, especially DHA, in breast milk is associated with better school performance in 12-year-old girls but not in boys.Electronic supplementary materialThe online version of this article (doi:10.1007/s00394-015-1030-y) contains supplementary material, which is available to authorized users.

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“…Although the capacity to synthesize LCPUFAs from LA and ALA, respectively, may be higher in preterm infants than in term infants, there is considerable interindividual variation in both preterm and term infants (Carnielli and others 1996b; Uauy and others 2000) The concentration of DHA is higher in plasma, erythrocyte membranes, and even in the brain in infants that are fed human milk or infant formulae with added DHA as compared to infants fed formulae containing only the precursors LA and ALA but no LCPUFAs (Farquharson and others 1992; Martínez 1992; Jamieson and others 1994; Makrides and others 1994; Jørgensen and others 1996). The supply of LA and ALA in the diet modulates the synthesis of AA and DHA.…”

Section: Fatty Acidsmentioning

confidence: 99%

Aspects of Infant Food Formulation

Thompkinson¹,

Kharb²

2007

Comp Rev Food Sci Food Safe

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Milk is a biological fluid of exceptional complexity. It contains the nutrients for the growth and development of the newborn. The compositional structure of milk is, however, dependent on the species and tailored to sustain growth and development of its own offspring. Human milk contains specific proteins, lipids, and other components designed to be easily digestible and which have important roles to play in child development. Human infants should ideally be nursed on mother's milk, which constitutes nature's best food. However, in the event of lactation failure, insufficient milk secretion, and where mothers are suffering from transmittable diseases, human milk substitutes serve as savers of precious life during vulnerable stages of infancy. Bovine milk as such or with certain modifications has been widely used for infant feeding. There has been an ever-increasing reliance on formula feeding practices both in developed and developing countries. Bovine milk based dried formulations have become a prominent feature of infantile dietetics. Emphasis has been laid on the manufacture of formulations having compositional and biochemical characteristics similar to human milk. The technological advancement for the production of infant formula has come a long way in the manufacture of a variety of infant formulae for the dietary management of infants. This is a comprehensive review providing insight on the detailed compositional differences of various nutrients present in human milk as compared to bovine milk, their makeup, significance, and recommended levels of intake that are best suited for the growth and development of infants fed on modified/prepared infant formulations.

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Effect of Diet on Term Infant Cerebral Cortex Fatty Acid Composition

Cited by 16 publications

References 0 publications

Biochemistry of Human Milk

Biochemistry of Human Milk

Fatty acid composition in breastfeeding and school performance in children aged 12 years

Aspects of Infant Food Formulation

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