Effect of dietary anthocyanins on biomarkers of type 2 diabetes and related obesity: A systematic review and meta-analysis

Tiwari, Vandita; Sharma, Saloni; Tiwari, Apoorv; Sheoran, Bhawna; Kaur, Simranjit; Sharma, Avadhesh C.; Yadav, Mona; Bhatnagar, Archana; Garg, Monika

doi:10.1080/10408398.2023.2186121

Cited by 5 publications

(6 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The meta-analysis also reported significant reductions in HbA 1c , FBG, and 2-h postprandial glucose, with an average effect of 0.65%, 0.31 mmol/L, and 0.82 mmol/L, respectively ( 24 ). Furthermore, Tiwari et al ( 27 ) also reported a significant decrease in HbA 1c and FBG by 0.80% and 1.54 mmol/L, respectively, in a systematic review and meta-analysis based on animal studies and human studies in patients with obesity or were overweight, had pre-diabetes, and T2DM.…”

Section: Discussionmentioning

confidence: 96%

“…Similarly, Neyestani et al ( 28 ) reported a significant effect of anthocyanins on all lipid profiles in healthy adults and patients with different health conditions such as obesity, metabolic syndrome, hyperlipidemia, and T2DM. Tiwari et al ( 27 ) demonstrated a significant reduction in TC, TG, and LDL, but not in HDL in preclinical studies involving subjects who were overweight/obese, had pre-diabetes, and T2DM (human and animal). The mechanism behind changes in different lipid markers by consumption of anthocyanins is related to improving the functionality of HDL particles and reversal in cholesterol transport ( 73 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Mao,

Akshit,

Mohan

2023

Front. Nutr.

View full text Add to dashboard Cite

PurposeThis study is the first systematic review and meta-analysis based on RCTs on the effects of anthocyanins on patients with type 2 diabetes mellitus (T2DM) and the effect on T2DM-related cardiovascular disease.MethodsRCTs published in English from five electronic databases were evaluated for glycated hemoglobin (HbA1c), fasting blood glucose (FBG), 2-h postprandial blood glucose, fasting insulin, model assessment for insulin resistance, triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, systolic blood pressure, and diastolic blood pressure. The quality of the studies was rated (Cochrane Risk of Bias tool) and weighted mean differences were calculated (DerSimonian-Laird model with random effects). Leave-one-out sensitivity, subgroup, and publication bias analyses were conducted. The strength of the evidence was rated according to the GRADE guidelines.ResultsIn all, 13 RCTs were analyzed out of the 239 identified studies, with a duration longer than 4 weeks (703 participants with T2DM). Our findings indicate that a median dose of 320 mg/day anthocyanins, either from fruit extracts or pure supplements, for a median intervention length of 8 weeks significantly reduced HbA1c [Weighted Mean Difference (WMD) −0.31, p = 0.00], FBG (WMD −0.63, p = 0.00), 2-h postprandial glucose (WMD −1.60, p = 0.00), TG (WMD −0.45, p = 0.01), and LDL (WMD −0.26 p = 0.02). However, the effects of anthocyanins on fasting insulin, HOMA-IR, TC, HDL cholesterol, systolic blood pressure, and diastolic blood pressure in patients with T2DM were not statistically significant. Anthocyanins from fruit extracts or powder exhibited a higher reduction of HbA1c compared to pure anthocyanin supplements.ConclusionThe significant improvements in glycemic parameters and lipid profile, suggest the benefits of anthocyanins, especially from fruit extract or powder, in the management of T2DM, and their ability to delay the onset of lipid disorder-related diseases such as cardiovascular disease associated with T2DM. The mechanism behind this reduction in glycemic markers could be attributed to the antioxidant and anti-inflammatory activity of anthocyanins. Further research with well-designed RCTs is required to determine the optimal dosage of anthocyanins for the treatment of T2DM and to comprehend the consequences.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Mao,

Akshit,

Mohan

2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…In particular, anthocyanin supplementation at a dose of ≤300 mg/day for 4 weeks effectively reduced BMI and body weight [ 194 ]. However, Tiwari et al [ 235 ] analysed 21 clinical trials and 27 preclinical studies and found that with a daily anthocyanin intake of ≤300 mg for 4 weeks, BMI reductions were observed more frequently in adults without obesity. During a 24-year follow-up of 124,086 healthcare workers in the United States, an increased intake of anthocyanins mainly from blueberries and strawberries was inversely correlated with weight gain [ 236 ].…”

Section: The Effects Of Anthocyanins On the Prevention And Supportive...mentioning

confidence: 99%

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Godyla-Jabłoński,

Raczkowska,

Jodkowska

et al. 2024

Nutrients

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a significant health problem. The co-occurrence of obesity, carbohydrate metabolism disorders, hypertension and atherogenic dyslipidaemia is estimated to affect 20–30% of adults worldwide. Researchers are seeking solutions to prevent and treat the conditions related to MetS. Preventive medicine, which focuses on modifiable cardiovascular risk factors, including diet, plays a special role. A diet rich in fruits and vegetables has documented health benefits, mainly due to the polyphenolic compounds it contains. Anthocyanins represent a major group of polyphenols; they exhibit anti-atherosclerotic, antihypertensive, antithrombotic, anti-inflammatory and anticancer activities, as well as beneficial effects on endothelial function and oxidative stress. This review presents recent reports on the mechanisms involved in the protective effects of anthocyanins on the body, especially among people with MetS. It includes epidemiological data, in vivo and in vitro preclinical studies and clinical observational studies. Anthocyanins are effective, widely available compounds that can be used in both the prevention and treatment of MetS and its complications. Increased consumption of anthocyanin-rich foods may contribute to the maintenance of normal body weight and modulation of the lipid profile in adults. However, further investigation is needed to confirm the beneficial effects of anthocyanins on serum glucose levels, improvement in insulin sensitivity and reduction in systolic and diastolic blood pressure.

show abstract

“…A meta-analysis of 21 clinical trials and 27 pre-clinical studies observed a dosedependent effect of dietary anthocyanins intake on biomarkers of metabolic syndrome, including type 2 diabetes (hyperglycemia) and associated obesity [43]. The meta-analysis found that daily anthocyanin intake of more than 5 mg/kg of body weight significantly reduced fasting blood glucose, glycosylated hemoglobin (HbA1c), total cholesterol, and triglycerides and increased high-density lipoprotein (HDL) levels.…”

Section: Clinical Trialsmentioning

confidence: 99%

“…Numerous exceptional reviews focusing on anthocyanins have been recently published, centering primarily on their structural diversity in land plants [2], biosynthesis and regulation during biotic and abiotic stress [6, 37,38], stabilization approaches, including nano/microencapsulation [39][40][41][42], health benefits [1,10,14,20,[43][44][45][46], and preparations and application of anthocyanins-based composite films [34]. However, despite these individual reviews, a comprehensive review integrating all these aspects of anthocyanins is lacking.…”

Section: Introductionmentioning

confidence: 99%

Dietary Sources, Stabilization, Health Benefits, and Industrial Application of Anthocyanins—A Review

Saini,

Khan,

Shang

et al. 2024

Foods

View full text Add to dashboard Cite

Natural phytochemicals are well known to protect against numerous metabolic disorders. Anthocyanins are vacuolar pigments belonging to the parent class of flavonoids. They are well known for their potent antioxidant and gut microbiome-modulating properties, primarily responsible for minimizing the risk of cardiovascular diseases, diabetes, obesity, neurodegenerative diseases, cancer, and several other diseases associated with metabolic syndromes. Berries are the primary source of anthocyanin in the diet. The color and stability of anthocyanins are substantially influenced by external environmental conditions, constraining their applications in foods. Furthermore, the significantly low bioavailability of anthocyanins greatly diminishes the extent of the actual health benefits linked to these bioactive compounds. Multiple strategies have been successfully developed and utilized to enhance the stability and bioavailability of anthocyanins. This review provides a comprehensive view of the recent advancements in chemistry, biosynthesis, dietary sources, stabilization, bioavailability, industrial applications, and health benefits of anthocyanins. Finally, we summarize the prospects and challenges of applications of anthocyanin in foods.

show abstract

Effect of dietary anthocyanins on biomarkers of type 2 diabetes and related obesity: A systematic review and meta-analysis

Cited by 5 publications

References 77 publications

Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Dietary Sources, Stabilization, Health Benefits, and Industrial Application of Anthocyanins—A Review

Contact Info

Product

Resources

About