2010
DOI: 10.1007/s11033-010-0319-4
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Effect of dietary betaine supplementation on lipogenesis gene expression and CpG methylation of lipoprotein lipase gene in broilers

Abstract: Experiments were conducted to investigate the effect of betaine supplementation on mRNA expression levels of lipogenesis genes and CpG methylation of lipoprotein lipase gene (LPL) in broilers. From 22 days of age, 78 broilers were feed basal diet without betaine and basal diet supplemented with 0.1% betaine, respectively, and at 56 and 66 days of age, the traits of 15 chickens (7 males and 8 females) of each group were recorded and abdominal fat pads were collected. The mRNA expression levels of several lipoge… Show more

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Cited by 55 publications
(52 citation statements)
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“…Dietary betaine supplementation significantly decreases the mRNA levels of lipoprotein lipase (LPL) [27] . Therefore, betaine might contribute to the improvement in lipid metabolism by XKA.…”
Section: Discussionmentioning
confidence: 99%
“…Dietary betaine supplementation significantly decreases the mRNA levels of lipoprotein lipase (LPL) [27] . Therefore, betaine might contribute to the improvement in lipid metabolism by XKA.…”
Section: Discussionmentioning
confidence: 99%
“…Betaine supplementation plays crucial roles in nutritional programming through epigenetic regulation of gene expression in pigs, ducks meat and egg type chickens. Betaine supplement was associated with retained positional effects in the -rate limiting enzyme-lipoprotein lipase (LPL) gene promoter, as measured in adipocytes [51]. With addition of betaine, most of the promoters were highly hypo-methylated and many CpG sites were built to be hyper methylated.…”
Section: Choline and Betaine (Nnn-trimethy-lglycine)mentioning
confidence: 99%
“…The general importance of methylation to chicken health was seen when in vivo treatment with 5-azacytidine negatively affected lymphatic organs, and increased the prevalence of autoimmune diseases in chicks (Schauenstein et al, 1991). Findings particularly relevant to humans came from experiments which used betaine as a dietary supplement (Xing et al, 2011) -a methyl donor known to reduce fat deposition. A modest reduction and change in pattern of promoter methylation was noted for the LPL gene, involved in lipoprotein catabolism; which coincided with a change in LPL levels.…”
Section: Chicken -Gallus Gallusmentioning
confidence: 99%