Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata

Lucia, Magali; André, Jean‐Marc; Gonzalez, Patrice; Baudrimont, Magalie; Bernadet, Marie-Dominique; Gontier, Karine; Maury-Brachet, Régine; Guy, Gérard; Davail, Stéphane

doi:10.1007/s10646-009-0401-7

Cited by 35 publications

(12 citation statements)

References 37 publications

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“…Crabs that were Cd-exposed contained less lipid compared to the control, which was consistent with some previous studies in other animals such as the duck Cairina moschata [11], european eel Anguilla anguilla [12], rat [51], freshwater crayfish Procambarus clarkii [52], and flower shrimp Penaeus semisulcatus [53]. A significant reduction of lipid content in hepatopancreas of Cd-exposed crabs was observed after three experimental durations.…”

Section: Discussionsupporting

confidence: 90%

“…However, an increase of lipid content in the hepatopancreas and ovary was not observed. Lucia et al [11] explained that Cd triggered the synthesis and the mobilization of long chain fatty acids, and these were subsequently transported to the mitochondria for energy production to relieve Cd toxicity and reduce oxidative stress. Indeed, one of the principal metabolic purposes of long chain fatty acids is the production of ATP, and exposed crabs also showed a significant up-regulation of ATP levels and related enzyme activities [60].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Cd could cause an increase of reactive oxygen species that challenge the cellular antioxidant system, and lipid peroxidation in crustaceans [8,9,10]. The impairment of lipid induced by Cd has also been detected in the duck Cairina moschata and the European eel Anguilla anguilla , and might directly affect their migration [11,12]. Consequently，toxicity from Cd on aquatic organisms is becoming a global environmental problem that results in the disturbance of entire aquatic ecosystems [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Cadmium on Lipid Storage and Metabolism in the Freshwater Crab Sinopotamon henanense

Yang

Jing

et al. 2013

PLoS ONE

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Since environmental effects of molecular traits are often questioned we analyze here the molecular effects of cadmium (Cd) on lipid pathways and their effects on tissues development. Lipids are an important energy source for the developing embryo, and accumulate in the ovary and hepatopancreas of decapod crustaceans. The extend of Cd affecting lipid storage and metabolism, is studied here with the freshwater crabs Sinopotamon henanense. Crabs were exposed to water-born Cd at 1.45, 2.9, 5.8 mg/l for 10, 15, and 20 days. With significantly increased Cd accumulation in exposed crabs, lipid content in hepatopancreas and ovary showed a time-dependent and concentration-dependent reduction, being at least one of the reasons for a lower ovarian index (OI) and hepatopancreatic index (HI). After 10-day exposure increased triglyceride (TG) level in hemolymph and up-regulation of pancreatic lipase (PL) activity in the hepatopancreas suggested an increased nutritional lipid uptake. However, two processes led to lower lipid levels upon Cd exposure: an increased utilization of lipids and a down-regulated lipoprotein lipase (LPL) led to insufficient lipid transport. 10-day Cd exposure also triggered the production of β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt hydrate (NADPH), as well as to the synthesis of adenosine triphosphate (ATP) and fatty acids. With increasing exposure time, the crabs at 15 and 20-day exposure contained less lipid and TG, suggesting that more energy was consumed during the exposure time. Meanwhile, the level of NADPH, ATP and the activity of PL, LPL, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) activity was down-regulated suggesting an impairment of the crab metabolism by Cd in addition to causing a lower lipid level.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Cadmium on Lipid Storage and Metabolism in the Freshwater Crab Sinopotamon henanense

Yang

Jing

et al. 2013

PLoS ONE

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“…Indeed, previous experimental studies have demonstrated that these concentrations were associated with increased functioning of mitochondrial metabolism, and thus stronger energetic needs, as well as oxidative stress (Lucia et al, 2009(Lucia et al, , 2010. Even if Cu and Fe are essential elements and therefore regulated by homeostatic mechanism, birds could be submitted to deleterious effects at high concentrations.…”

Section: Toxicity Significancementioning

confidence: 99%

Insight on trace element detoxification in the Black-tailed Godwit (Limosa limosa) through genetic, enzymatic and metallothionein analyses

Lucia

Bocher

Cosson

et al. 2012

Science of The Total Environment

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Trace element concentrations (Ag, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, Zn) were investigated in the liver, kidneys, muscle and feathers of 31 black-tailed godwits (Limosa limosa) accidentally killed during catches by mist net in the Pertuis Charentais, Atlantic coast of France. Analyses of carbon and nitrogen stable isotope ratios were carried out in liver, muscle and feathers in order to elucidate dietary patterns and to determine whether differences in diet explained the variation in elemental uptake. This study also aimed to have a preliminary assessment of sub-lethal effects triggered by trace elements through the investigation of gene expressions by quantitative real-time PCR, antioxidant enzyme activities (catalase, superoxide dismutase, glutathione peroxidase), and metallothionein (MT) levels. The results showed that Cr and Ni concentrations in tissues of adults were lower than in juveniles in part because adults may have eliminated these trace elements through moulting. Except for Cd and Ni, trace element concentrations were negatively correlated to the body mass of godwits. Ag, As, Hg and Se concentrations were positively linked with the trophic position of birds. The diet could be considered as a fundamental route of exposure for these elements demonstrating therefore the qualitative linkage between dietary habits of godwits and their contaminant concentrations. Our results strongly suggest that even though trace element concentrations were mostly below toxicity threshold level, the elevated concentrations of As, Ag, Cd, Cu, Fe and Se may however trigger sub-lethal effects. Trace elements appear to enhance expression of genes involved in oxidative stress defence, which indicates the production of reactive oxygen species. Moreover, birds with the highest concentrations appeared to have an increased mitochondrial metabolism suggesting that the fight against trace element toxicity requires additional energetic needs notably to produce detoxification mechanisms such as metallothioneins.

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“…The cellular mechanisms of toxicity, such as Cd‐induced cell necrosis and apoptosis , have been extensively studied. In addition, Cd is reported to affect lipid and protein metabolism in fishes and birds . Calhôa et al found that Cd has negative impacts on the survival, growth, and reproduction of organisms, leading to a decline in abundance.…”

Section: Introductionmentioning

confidence: 99%

Cadmium inhibits the vitellogenesis of freshwater crab Sinopotamon henanense

Yang

Dahms‬

et al. 2015

Environmental Toxicology and Chemistry

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Cadmium (Cd) may pose risks to freshwater organisms, including crabs that live at the interface of sediments and water column all year round. One of the major changes that occur during oocyte maturation of crabs is the production of vitellin. In the present study, the authors investigated the effects of Cd on oocyte size, vitellin level, and vitellogenin (Vtg) messenger RNA (mRNA) expression in the ovary of the freshwater crab Sinopotamon henanense. The authors studied the impacts of Cd on carbohydrate as well as on the protein metabolism, metallothionein, glutathione (GSH) synthesis, energy-related parameters, and mRNA expression of genes involved in energy metabolism. After Cd treatment, vitellin concentration, Vtg mRNA expression, and oocyte diameter decreased. Less carbohydrate and enhanced protein catabolism were found in the ovary. Adenosine triphosphate to adenosine diphosphate (ATP:ADP) ratios, reduced nicotinamide adenine dinucleotide (NADH) to oxidized nicotinamide adenine dinucleotide (NAD(+) ) ratios, mitochondrial membrane potential, and energy production-related mRNA expressions increased in the ovary after 10 d Cd treatment and decreased after 20 d. Metallothionein and GSH synthesis were up-regulated after 10 d on Cd exposure. Moreover, Cd caused a time-dependent up-regulation of malondialdehyde. The authors' findings show significant effects of Cd on vitellogenesis, which suggests that Cd slows down vitellogenesis in S. henanense because of excessive energy consumption and an activated defense system.

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Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata

Cited by 35 publications

References 37 publications

Effects of Cadmium on Lipid Storage and Metabolism in the Freshwater Crab Sinopotamon henanense

Effects of Cadmium on Lipid Storage and Metabolism in the Freshwater Crab Sinopotamon henanense

Insight on trace element detoxification in the Black-tailed Godwit (Limosa limosa) through genetic, enzymatic and metallothionein analyses

Cadmium inhibits the vitellogenesis of freshwater crab Sinopotamon henanense

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