Effect of Dietary Caffeine on Airway Reactivity in Asthma

Abstract

The potential influence of dietary caffeine on bronchoprovocation challenges with carbachol was examined in 7 patients with asymptomatic asthma. In a double-blind fashion placebo or caffeine (6 mg/kg body weight; equivalent to approximately 4 cups of coffee) solved in orange juice was administered, and carbachol challenges were performed. The average peak serum concentration achieved 60 min after dosing was 7.6 ± SD 2.1 mg/l. These caffeine levels did not produce any appreciable attenuation of the bronchoconstrictor response to carbachol inhalations. It thus appears that dietary caffeine is barely a cause of erroneous interpretations of bronchoprovocation challenges with carbachol.

The effect of dietary components on inflammatory lung diseases – a literature review

“…Intake of n-3 PUFAs may result in decreased inflammation and improved lung function by (i) competition with n-6 PUFAs for metabolism by specific enzymes (cyclooxygenase, lysyl oxidase or cytochrome P450 oxygenase), resulting in alternative, less pro-inflammatory and even anti-inflammatory eicosanoids (metabolites); (ii) binding to and activation of receptors bound to the plasma membrane or found in the cytosol as G-protein coupled receptors (mediating the anti-inflammatory effects of n-3 PUFAs) and PPAR (peroxisome proliferator-activated receptor) transcription factors (inhibiting NF-jB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation and thereby pro-inflammatory gene transcription); and (iii) inducing the antiinflammatory pathways by resolvins and protectins derived from n-3 PUFAs (Yates & Calder 2014). The effect on the eicosanoid metabolisation was observed to be crucial in chronic inflammatory lung diseases: various LTs derived from arachidonic acid (n-6 PUFAs) Agarwal et al 2006;Shaheen et al 2011;Lehouck et al 2012;Arshi et al 2014;Ng et al 2014) Caffeine 110 À0.455 À0.455 (Becker et al 1984;Crivelli et al 1986;Gong et al 1986;Bukowskyj & Nakatsu 1987;Colacone et al 1990;Kivity et al 1990;Duffy & Phillips 1991;Henderson et al 1993;Yurach et al 2011 Kordansky et al 1979;Schachter & Schlesinger 1982;Ting et al 1983;Malo et al 1986;Schertling 1989;Britton et al 1995;Cohen 1997;Cook et al 1997;Grievink et al 1998;Hu et al 1998;Tabak et al 1999;Butland et al 2000;McKeever et al 2002;Fogarty et al 2003;de Luis et al 2005;Tecklenburg et al 2007;K...…”