Effect of dietary fatty acids on lipoprotein lipase gene expression in the liver and visceral adipose tissue of fed and starved red sea bream Pagrus major

Liang, Xu‐Fang; Ogata, Hiroshi; Oku, Hiromi

doi:10.1016/s1095-6433(02)00118-6

Cited by 77 publications

(53 citation statements)

References 34 publications

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“…Thus, it seems that this mechanism is not present in Atlantic salmon. The downregulation of LPL mRNA expression in Atlantic salmon adipose tissue is in agreement with the reduced LPL mRNA expression and activity in adipose tissue found after a fasting period in mammals (58) and in various fish species (6,8,30). A lower LPL expression during fasting fits well with the observed decreased expression of the FA transporters in adipose tissue, tending to preserve the FA to other tissues, such as skeletal muscle or hearth.…”

Section: Discussionsupporting

confidence: 85%

In vivo and in vitro insulin and fasting control of the transmembrane fatty acid transport proteins in Atlantic salmon (Salmo salar)

Sánchez-Gurmaches

Østbye

Navarro

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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(FABP3), and mitochondrial FA-CoA and -carnitine palmitoyl transferase carriers (CPT)1 and -2 in Atlantic salmon tissues and myocyte cell culture. Two weeks of fasting diminished FATP1, CD36, and LPL in adipose tissue, suggesting a reduction in FA uptake, while FABP3 increased in liver, probably enhancing the transport of FA to the mitochondria. Insulin injection decreased FATP1 and CD36 in white and red muscles, while both transporters were upregulated in the adipose tissue in agreement with the role of insulin-inhibiting muscle FA oxidation and stimulating adipose fat stores. Serum deprivation of 48 h in Atlantic salmon myotubes increased FATP1, FABP3, and CPT-2, while CPT-1 was diminished. In myotubes, insulin induced FATP1 expression but decreased CD36, FABP3, and LPL, suggesting that FATP1 could be more involved in the insulin-stimulated FA uptake. Insulin increased the FA uptake in myotubes mediated, at least in part, through the relocation of FATP1 protein to the plasma membrane. Overall, Atlantic salmon FA transporters are regulated by fasting and insulin on in vivo and in vitro models.

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Section: Discussionsupporting

confidence: 85%

In vivo and in vitro insulin and fasting control of the transmembrane fatty acid transport proteins in Atlantic salmon (Salmo salar)

Sánchez-Gurmaches

Østbye

Navarro

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Many factors, e.g. active swimming (Jonas & Bilinski, 1964), fatty acid composition in the feed (Liang et al, 2002), etc may influence lipase activities in tissue.…”

Section: Lipases In Cut Off Fractionsmentioning

confidence: 99%

“…It is likely that the lipase activity at pH 5 in the liver samples is mainly caused by the intracellular acid lipase, while the activity at pH 7 is mainly caused by LPL. Liang et al (2002) found that LPL gene expression was related to dietary fatty acids and feeding conditions.…”

Section: Lipases In Livermentioning

confidence: 99%

“…are other factors controlling the lipolysis of storage fat (Hochachka & Somero, 1984). Different lipases have been described in fish: triacylglycerol lipase (Gjellesvik, Raae, & Walther, 1989;Sidell & Hazel, 2002), pancreatic lipase (Patton, 1975;Leger, Bauchart, & Flanzy, 1977), bile salt-dependent lipases (Patton, Warner, & Benson, 1977;Gjellesvik, 1991), phospholipase (Chawla & Ablett, 1987;Aaen, Jessen, & Jensen, 1995) and LPLs (Liang, Ogata, & Oku, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Effect of season and fishing ground on the activity of lipases in byproducts from cod (Gadus morhua)

Sovik

Rustad

2005

LWT - Food Science and Technology

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“…However, there is a re-expression of LPL mRNA in the adult rat liver after partial hepatectomy (Sabugal et al 1996). In contrast, LPL is expressed in the liver of adult fish (Liang et al 2002, Feng et al 2014. Liver LPL targets circulating TG to the liver and increases ketone body production, which can be used as energy as an alternative to glucose (Merkel et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Adropin induction of lipoprotein lipase expression in tilapia hepatocytes

Lian

Liu

et al. 2016

Journal of Molecular Endocrinology

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The peptide hormone adropin plays a role in energy homeostasis. However, biological actions of adropin in non-mammalian species are still lacking. Using tilapia as a model, we examined the role of adropin in lipoprotein lipase (LPL) regulation in hepatocytes. To this end, the structural identity of tilapia adropin was established by 5 0 /3 0 -rapid amplification of cDNA ends (RACE). The transcripts of tilapia adropin were ubiquitously expressed in various tissues with the highest levels in the liver and hypothalamus. The prolonged fasting could elevate tilapia hepatic adropin gene expression, whereas no effect of fasting was observed on hypothalamic adropin gene levels. In primary cultures of tilapia hepatocytes, synthetic adropin was effective in stimulating LPL release, cellular LPL content, and total LPL production. The increase in LPL production also occurred with parallel rises in LPL gene levels. In parallel experiments, adropin could elevate cAMP production and up-regulate protein kinase A (PKA) and PKC activities. Using a pharmacological approach, cAMP/PKA and PLC/inositol trisphosphate (IP3)/PKC cascades were shown to be involved in adropin-stimulated LPL gene expression. Parallel inhibition of p38MAPK and Erk1/2, however, were not effective in these regards. Our findings provide, for the first time, evidence that adropin could stimulate LPL gene expression via direct actions in tilapia hepatocytes through the activation of multiple signaling mechanisms.

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Effect of dietary fatty acids on lipoprotein lipase gene expression in the liver and visceral adipose tissue of fed and starved red sea bream Pagrus major

Cited by 77 publications

References 34 publications

In vivo and in vitro insulin and fasting control of the transmembrane fatty acid transport proteins in Atlantic salmon (Salmo salar)

In vivo and in vitro insulin and fasting control of the transmembrane fatty acid transport proteins in Atlantic salmon (Salmo salar)

Effect of season and fishing ground on the activity of lipases in byproducts from cod (Gadus morhua)

Adropin induction of lipoprotein lipase expression in tilapia hepatocytes

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