Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis

Bailey, S. R.; Menzies‐Gow, N. J.; Harris, Patricia A.; Habershon‐Butcher, Jocelyn; Crawford, Cynda; Berhane, Yoel; Boston, Raymond C.; Elliott, Jonathan

doi:10.2460/javma.231.9.1365

Cited by 89 publications

(80 citation statements)

References 43 publications

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“…Skin perfusion was decreased in a study using six days of daily dexamethasone and the authors suggested perfusion to the hoof may also be reduced, increasing the risk of laminitis (Cornelisse et al 2006). Following a standard overnight dexamethasone suppression test, non-obese ponies with a history of prior laminitis showed elevated insulin concentration and exaggerated production of insulin in response to corticosteroids compared to control ponies (Bailey et al 2007). After a single administration of triamcinolone, one study reported a prolonged period (3 -4 days) of hyperglycaemia, hyperinsulinaemia and hypertriglyceridaemia (French et al 2000).…”

Section: Clinical Scenariomentioning

confidence: 99%

No Evidence That Therapeutic Systemic Corticosteroid Administration is Associated With Laminitis in Adult Horses Without Underlying Endocrine or Severe Systemic Disease.

McGowan

Cooper²,

Ireland

2016

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Clinical bottom line There is currently no conclusive evidence to support a causal association between therapeutic systemic corticosteroid administration and the development of laminitis in healthy adult horses/ponies. There is weak evidence of an association between administration of multiple doses of systemic corticosteroid and the onset of laminitis in adult horses/ponies with underlying endocrine disorders or severe systemic disease.

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Section: Clinical Scenariomentioning

confidence: 99%

No Evidence That Therapeutic Systemic Corticosteroid Administration is Associated With Laminitis in Adult Horses Without Underlying Endocrine or Severe Systemic Disease.

McGowan

Cooper²,

Ireland

2016

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“…Prebiotics have been used in nutrition research with canines (Verlinden et al, 2006;Apanavicius et al, 2007), felines (Hesta et al, 2005), poultry (Xu et al, 2003), swine (Yasuda et al, 2007), horses (Bailey et al, 2007), young ruminants (Kaufhold et al, 2000;Heinrichs et al, 2003) and adult ruminants (Franklin et al, 2005). Although some prebiotics such as scFOS, OF, inulin, mannanoligosaccharides (MOS) and galactooligosaccharides have been supplemented to cows (Mwenya et al, 2005), calves (Masanetz et al, 2011) and lambs (Thayne, 2007) and some information is available on the effects of feeding prebiotics in selected species mentioned above (Swanson et al, 2002a), there is no information on the effects of supplemental inulin in kids.…”

Section: Introductionmentioning

confidence: 99%

Effects of inulin supplementation on selected faecal characteristics and health of neonatal Saanen kids sucking milk from their dams

Kara

Orman

Gencoglu

et al. 2012

Animal

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Fifty newborn Saanen kids were used to study the effects of inulin supplementation on faecal score, faecal pH, selected faecal bacterial population, BW, body temperature, haematological traits, selected health parameters and the incidence of diarrhoea. Kids were sorted by parity of their dams and multiple birth (twin or triplet) and assigned to one of the two groups (control: CG, and experimental: EG) at birth. Each group consisted of 25 kids. The groups were similar with regard to sex and birth weight. All kids were fed colostrum for the first 3 days after birth, and then the kids in EG were adapted to inulin supplementation by an increased dosage from day 4 to 7. Each kid in EG was supplemented with 0.2 g, 0.3 g, 0.4 g, 0.5 g and 0.6 g inulin on day 4, 5, 6, 7 and from day 8 to 28, respectively, whereas the kids in CG did not receive inulin. Faecal score and faecal bacterial population were not affected by inulin supplementation (P . 0.05). There were differences in faecal pH on day 14 (P 5 0.01) and 28 (P,0.05), whereas no difference in faecal pH on day 21 (P . 0.05) was detected between groups. No differences (P . 0.05) in BW and haematological traits were found between groups. Body temperature did not differ on day 14 and 21 (P . 0.05), whereas there was a difference in body temperature on day 28 (P 5 0.01) between groups. The numbers of kids with pneumonia and kids treated for pneumonia and diarrhoea were similar for CG and EG. Kid losses during the study were the same for CG and EG. The incidence of diarrhoea was not affected by inulin supplementation (P . 0.05). Inulin supplemented to kids did not adversely affect faecal score. The effect of inulin on faecal pH was not consistent. The results of our study suggested that daily dose (0.6 g) of inulin might not be enough to observe effects of it. Our data will be useful to determine the dose and timing of inulin supplementation in future studies investigating the effects of inulin on the parameters associated with performance and health status in kids and other young ruminants.

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“…Insulin dysregulation (ID), typically characterized by resting or postprandial hyperinsulinemia, is a key component of EMS,1, 4 and occurs in approximately one third of horses and ponies with PPID 2, 5, 6. Glucocorticoid (cortisol) excess has been theorized to contribute to the development of ID in some animals with PPID or EMS 7, 8, 9. Both short and long‐term experimental administration of synthetic glucocorticoids such as dexamethasone or triamcinolone can decrease insulin sensitivity and cause hyperinsulinemia in healthy horses 10, 11, 12, 13.…”

mentioning

confidence: 99%

Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses

Hart

Wochele

Norton

et al. 2016

Veterinary Internal Medicne

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BackgroundIncreased free cortisol fraction is associated with insulin dysregulation (ID) in people with Metabolic Syndrome and Cushing's Disease. Free cortisol has not been investigated in equine endocrine disorders.Hypotheses(1) In healthy horses, sex, age, body condition score (BCS), and season impact free cortisol; (2) free cortisol is increased in horses with Pituitary Pars Intermedia Dysfunction (PPID) or Equine Metabolic Syndrome (EMS).AnimalsFifty‐seven healthy horses; 40 horses and ponies with PPID (n = 20) or EMS (n = 20).MethodsProspective study. Serum collected seasonally from healthy animals and archived serum from PPID and EMS animals was analyzed for insulin, total and free cortisol concentrations, and free cortisol fraction (FCF). Linear mixed models were used to determine effects of age, sex, season, and BCS on hormones in controls. Hormone measurements were compared between disease groups and age‐ and season‐matched controls with t‐tests. EMS and hyperinsulinemic PPID animals were combined in an ID (hyperinsulinemia) group.ResultsFree cortisol concentrations were increased in overweight/obese controls (0.3 ± 0.1 μg/dL) compared to lean controls (0.2 ± 0.1 μg/dL; P = .017). Mean FCF was significantly higher in animals with PPID (8.8 ± 5.8 μg/dL, P = .005) or ID (8.8 ± 10.2 μg/dL, P = .039) than controls (5.0 ± 0.9 μg/dL), but total cortisol concentrations were similar (P ≥ .350) (PPID: 4.2 ± 4.3 μg/dL; ID: 5.0 ± 4.5 μg/dL; controls: 4.6 ± 1.7 and 5.1 ± 2.1 μg/dL).Conclusions and Clinical ImportanceIncreased FCF is associated with obesity in healthy horses and with ID (hyperinsulinemia) in horses and ponies with endocrine disease. Decreased plasma cortisol‐binding capacity could be a component of these endocrine disorders in horses.

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Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis

Abstract: Nonobese ponies predisposed to develop laminitis had compensated insulin resistance, and this phenotype was revealed by feeding plant fructan carbohydrate or by dexamethasone administration.

Cited by 89 publications

References 43 publications

No Evidence That Therapeutic Systemic Corticosteroid Administration is Associated With Laminitis in Adult Horses Without Underlying Endocrine or Severe Systemic Disease.

No Evidence That Therapeutic Systemic Corticosteroid Administration is Associated With Laminitis in Adult Horses Without Underlying Endocrine or Severe Systemic Disease.

Effects of inulin supplementation on selected faecal characteristics and health of neonatal Saanen kids sucking milk from their dams

Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses

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