Effect of dietary guanidinoacetic acid or nucleotides supplementation on growth performances, carcass traits, meat quality and occurrence of myopathies in broilers

Souza, Cleison de; Eyng, Cínthia; Viott, A.M.; Ávila, André Sanches de; Pacheco, W.J.; Júnior, Nilton Rohloff; Köhler, T.L.; Tenório, Karine Isabela; Cirilo, Edinan Hagdon; Nunes, Ricardo Vianna

doi:10.1016/j.livsci.2021.104659

Cited by 14 publications

(11 citation statements)

References 72 publications

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“…Nevertheless, according to European Food Safety Authority, guoanidoacetate has been approved as a feed additive for the fatting purposes of chicken (EFSA, 2009 ). In addition, several studies have been conducted on dietary supplementation of guanidoacetate in commercial feeds for better growth performance of chicken production in recent years (de Souza et al, 2021 ; Khajali et al, 2020 ). Taken together, further studies are required to confirm the suitability of guanidoacetate as a candidate biomarker for CBC.…”

Section: Discussionmentioning

confidence: 99%

¹H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

Tan

Selamat

Jambari

et al. 2023

Food Science & Nutrition

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This study aimed to characterize the metabolic composition of four types of commercially available chicken breeds [village chicken, colored broiler (Hubbard), broiler (Cobb), and spent layers (Dekalb)] by 1 H NMR coupling and discriminate them using multivariate analysis. Five chickens were collected for each chicken breed based on the marketing age from the respective commercial farms. The orthogonal partial least squares discriminant analysis (OPLS‐DA) results showed an obvious separation of local village chickens from the other breeds based on the metabolites present in their serum and meat (pectoralis major). The cumulative values of Q 2 , R 2 X , and R 2 Y of the OPLS‐DA model for chicken serum were 0.722, 0.877, and 0.841. For the pectoralis major muscle, the cumulative values of Q 2 , R 2 X , and R 2 Y of the OPLS‐DA model were reported as 0.684, 0.781, and 0.786, respectively. The quality of both OPLS‐DA models was accepted by the cumulative values of Q 2 ≥ 0.5 and R 2 ≥ 0.65. The 1 H NMR result with multivariate analysis has successfully distinguished local village chicken from the other three commercial chicken breeds based on serum and pectoralis major muscle. Nonetheless, colored broiler (Hubbard) was not distinguished from broiler (Cobb) and spent layers (Dekalb) in serum and pectoralis major, respectively. The OPLS‐DA assessment in this study identified 19 and 15 potential metabolites for discriminating different chicken breeds in serum and pectoralis major muscle, respectively. Some of the prominent metabolites identified include amino acids (betaine, glycine, glutamine, guanidoacetate, phenylalanine, and valine), nucleotides (IMP and NAD+), organic acids (lactate, malate, and succinate), peptide (anserine), and sugar alcohol (myo‐inositol).

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Section: Discussionmentioning

confidence: 99%

¹H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

Tan

Selamat

Jambari

et al. 2023

Food Science & Nutrition

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“…Therefore, the increase in nucleotide without turmeric extract leads to low body weight. This shows that additional nucleotides are needed to optimize de novo synthesis at a high temperature [16].…”

Section: Body Weightmentioning

confidence: 99%

Effect of nucleotides and turmeric extract on blood protein and body weight of broiler kept in open cages

Tugiyanti

Susanti

Ismoyowati

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Indonesia’s wet tropical climate is a condition that does not support the development chickens. Therefore, this study aims to analyze the effect of nucleotides and turmeric extract in basal feed on broilers’ blood protein and body weight. Data was collected using a Completely Randomized Design (CRD) with 7 treatments that comprised of negative and positive control. Meanwhile, the negative aspects include basal feed + plus Zink Bactitracin 0.1 g, while the positive control consists of N0K1, N1K0, N1K1, N2K0, and N2K1. The results showed that nucleotide supplementation and turmeric extract in the feed had no significant effect on blood PCV, TPP, albumin levels, and broiler body weights. Furthermore, blood protein increases due to the high levels of nucleotides and turmeric extract. The 5 g of nucleotide supplementation and turmeric extract produce the same broilers blood protein and body weight.

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“…Supplemental GAA in all-plant diets during the finishing period enhanced feed to gain ratio in broilers and, consequently, led to better overall performance (Michiels et al, 2012;Coŕdova-Noboa et al, 2018b). Dietary GAA (0.6 g/kg) improved feed intake, weight gain and growth performance of broiler chickens at day 10 (de Souza et al, 2021). Moreover, dietary GAA inclusion had positive effects on weight gain and improved FCR in broilers (Lemme et al, 2007a;Lemme et al, 2007b;Ringel et al, 2007;Ringel et al, 2008;Mousavi et al, 2013;Coŕdova-Noboa et al, 2018a;Boney et al, 2020;Borges et al, 2021;de Souza et al, 2021).These studies suggest GAA can be used as a supplement to enhance FCR and energy efficiency in broiler chickens.…”

Section: Effects Of Gaa Supplementation On Growth Performancementioning

confidence: 99%

“…Dietary GAA (0.6 g/kg) improved feed intake, weight gain and growth performance of broiler chickens at day 10 (de Souza et al, 2021). Moreover, dietary GAA inclusion had positive effects on weight gain and improved FCR in broilers (Lemme et al, 2007a;Lemme et al, 2007b;Ringel et al, 2007;Ringel et al, 2008;Mousavi et al, 2013;Coŕdova-Noboa et al, 2018a;Boney et al, 2020;Borges et al, 2021;de Souza et al, 2021).These studies suggest GAA can be used as a supplement to enhance FCR and energy efficiency in broiler chickens. Improved FCR suggests efficient nutrient and energy utilization, which has been promoted as one of the best benefits of GAA supplements.…”

Section: Effects Of Gaa Supplementation On Growth Performancementioning

confidence: 99%

Guanidinoacetic acid supplementation: A narrative review of its metabolism and effects in swine and poultry

Asiriwardhana

Bertolo²

2022

Front. Anim. Sci.

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Guanidinoacetic acid (GAA) is an amino acid derivative and precursor for creatine which plays a significant role in energy metabolism. However, because of creatine’s instability during the manufacturing process and cost, GAA has been explored as an effective alternative to creatine supplements. GAA has been tested as a potential feed additive to enhance energy utilization and growth performance in the poultry and swine industries. Moreover, GAA has been combined with methionine to improve growth outcomes and may also act as an arginine-sparing agent in birds. The safety of the GAA supplements for animals, consumers, and the environment and its efficacy in numerous livestock species have been proven. This narrative review discusses the scientific evidence regarding the metabolism and effects of GAA supplementation in swine and poultry, identifying the knowledge gaps and future directions for further research on GAA supplementation. A systematic search of the literature identified published research findings related to GAA supplementation in swine and poultry and their findings are summarized in this narrative review to confirm the impacts of GAA supplementation on growth performance, reproductive performance, and meat quality in swine and poultry. Amongst its many demonstrated benefits, GAA is effective at improving body creatine concentration, growth parameters, feed conversion ratio, and performance of animals. Although GAA exerts many non-creatine roles, including the stimulation of insulin secretion, neuromodulation, and vasodilation, further research may require in-depth elaboration.

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Effect of dietary guanidinoacetic acid or nucleotides supplementation on growth performances, carcass traits, meat quality and occurrence of myopathies in broilers

Cited by 14 publications

References 72 publications

¹H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

¹H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

Effect of nucleotides and turmeric extract on blood protein and body weight of broiler kept in open cages

Guanidinoacetic acid supplementation: A narrative review of its metabolism and effects in swine and poultry

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Effect of dietary guanidinoacetic acid or nucleotides supplementation on growth performances, carcass traits, meat quality and occurrence of myopathies in broilers

Cited by 14 publications

References 72 publications

1H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

1H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

Effect of nucleotides and turmeric extract on blood protein and body weight of broiler kept in open cages

Guanidinoacetic acid supplementation: A narrative review of its metabolism and effects in swine and poultry

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Product

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¹H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds

¹H nuclear magnetic resonance‐based metabolomics study of serum and pectoralis major for different commercial chicken breeds