Effect of dietary <i>α</i>‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs

Liu, Shaojuan; He, Liuqin; Jiang, Qian; Duraipandiyan, Veeramuthu; Al-Dhabi, Naïf Abdullah; Liu, Gang; Yao, Kang; Yin, Yulong

doi:10.1002/jsfa.9131

Cited by 19 publications

(20 citation statements)

References 48 publications

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“…Most of these genera have been demonstrated by previous studies to be negatively correlated with obesity. [34][35][36] Consistently, Allicin treatment dramatically increased the relative abundance of Bifidobacterium, Lactobacillus, Oscillospira, Peptococcaceae, Anaerostipes, Anaerovorax, Pseudomonadaceae, and Leuconostocaceae, whereas decreased Methylotenera, Rhodococcus, Phyllobacteriaceae, ProteoAlphaproteoRhizobiales, Methylobacterium, Acinetobacter, Microbacterium, and Agrobacterium in the HFD mice ( Figure 1I). The relative abundance of Bifidobacterium and Lactobacillus are the most significantly changed bacterial genera in Allicin-treated mice compared with the HFD group ( Figure 1J,K).…”

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confidence: 62%

Allicin‐induced host‐gut microbe interactions improves energy homeostasis

Zhang

Sheng

et al. 2020

The FASEB Journal

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mentioning

confidence: 62%

Allicin‐induced host‐gut microbe interactions improves energy homeostasis

Zhang

Sheng

et al. 2020

The FASEB Journal

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“…Recent studies have reported that AKG intervention has beneficial effects in modulating inflammatory cytokines such as IL-2, IL-8, IL-10, TGF- β , TNF- α , and IL-17 [29, 30], but excessive production of cytokines has been shown to have a negative effect on intestinal integrity and epithelial restitution [31, 32]. In a lipopolysaccharide (LPS)-induced piglet model, intervention with AKG was shown to inhibit the secretion and mRNA expression of IL-1 β , IL-6, and IL-12 in the small intestine and prevented tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Intervention withα-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome

Zhao

et al. 2019

BioMed Research International

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The intestinal microbiome plays a crucial role in promoting intestinal health, and perturbations to its constitution may result in chronic intestinal inflammation and lead to colorectal cancer (CRC). α-Ketoglutarate is an important intermediary in the NF-κB-mediated inflammatory pathway that maintains intestinal homeostasis and prevents initiation of intestinal inflammation, a known precursor to carcinoma development. The objective of this study was to assess the potential protective effects of α-ketoglutarate intervention against CRC development, which may arise due to its known anti-inflammatory and antitumour effects. CRC was induced in C57BL/6 mice using azoxymethane (AOM) and dextran sulfate sodium (DSS). Tumour frequency, histological rating, and colonic microbiota were assessed in colonic samples. The findings demonstrated that α-ketoglutarate offered significant protection against CRC development in mice. Furthermore, α-ketoglutarate also exhibited immunomodulatory effects mediated via downregulation of interleukin (IL)-6, IL-22, tumour necrosis factor (TNF)-α, and IL-1β cytokines. Finally, intervention with α-ketoglutarate tended to minimise the frequency of opportunistic pathogens (Escherichia and Enterococcus) while increasing the populations of Akkermansia, Butyricicoccus, Clostridium, and Ruminococcus. Taken together, our findings show that dietary α-ketoglutarate intervention may protect against inflammation-related CRC.

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“…The 16S rDNA gene sequencing with Illumina MiSeq Sequencing was performed as previously described [25]. Briefly, the total bacterial DNA of colonic content was extracted according to the protocol of Qiagen QIAamp DNA Stool Mini Kit (Qiagen, Germany).…”

Section: Methodsmentioning

confidence: 99%

Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets

Peng¹,

Wang²,

Peng³

et al. 2019

PLoS ONE

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This study was conducted to compare the effects of Eucommia ulmoides leaves (EL) in different forms (EL extract, fermented EL, and EL powder) with antibiotics on growth performance, intestinal morphology, and the microbiota composition and diversity of weanling piglets. Compared to the control group, the antibiotics and EL extract significantly increased the average daily gain and decreased the feed: gain ratio as well as the diarrhea rate (P < 0.05). The EL extract significantly decreased the crypt depth and increased the ratio of villus height to crypt depth (P < 0.05), while the fermented EL group did the opposite (P < 0.05). The crypt depth in the antibiotics group was of similar value to the EL extract group, and was lower than the fermented EL and EL powder groups (P < 0.05). Compared to the control and antibiotics groups, the jejunul claudin-3 mRNA expression and the concentrations of total VFA, Chao 1, and ACE were significantly augmented in the EL extract group of piglets (P < 0.05). The EL extract groups also showed elevated Shannon (P < 0.05) and Simpson (P = 0.07) values relative to the control and antibiotics groups. At the phylum level, the EL extract group exhibited a reduced abundance of Bacteroidetes and an enhanced abundance of Firmicutes. At the genus level, the abundance of Prevotella was augmented in the EL extract group. Moreover, compared with the antibiotic group, the acetate concentration was enhanced in the EL extract and fermented EL groups. Overall, dietary supplementation with the EL extract, but not the fermented EL or EL powder, improved growth performance, jejunul morphology and function, as well as changed colonic microbial composition and diversity, which might be an alternative to confer protection against weanling stress in weanling piglets.

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Effect of dietary α‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs

Abstract: Dietary 1.0% AKG combined with 0.5% allicin improved cecal microbial composition and diversity, which might further promote VFA metabolism in growing pigs. © 2018 Society of Chemical Industry.

Cited by 19 publications

References 48 publications

Allicin‐induced host‐gut microbe interactions improves energy homeostasis

Allicin‐induced host‐gut microbe interactions improves energy homeostasis

Intervention withα-Ketoglutarate Ameliorates Colitis-Related Colorectal Carcinoma via Modulation of the Gut Microbiome

Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets

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