Effect of Dietary intervention by Dry Pomegranate (Punica Granatum L) Powder on some biochemical factors in Mild Cardio Vascular Disease Patients

Abstract

his study aimed to examine the effect of dry pomegranate (Punica Granatum) (DPG) intervention on biochemical parameters in mild cardiovascular disease (CVD) patients. Sixty adult males > 45 years suffering from mild CVD were selected from the outpatient clinic of the cardiopulmonary department in El-Fayoum General Hospital in El-Fayoum city. The patients were divided randomly into two equal groups (A&B 30 patients/ group): Group A (Control group); who had received a placebo for 8 weeks. Group B (Study group); supplemented with 50g of dry pomegranates daily for the same period. Mean daily nutrient intake using 24 Hours recall, anthropometric measurements [body mass index (BMI), waist-hip ratio (WHR), arm circumference (AC)], blood pressure, and heart rate were assessed. Blood analysis for lipid profiles and malondialdehyde (MDA) and some antioxidants "Superoxide dismutase (SOD), Glutathione (GSH), Catalase enzyme (CAT), and ascorbic acid (VIT C)" were determined for both groups before and after treatment. Results showed that in the control group, there were no significant differences in all parameters measurements before and after supplementation. In-group B, there were significant differences in the mean values of systolic blood pressure, diastolic blood pressure, cholesterol, MDA, SOD, CAT, and VIT C compared to pre-post supplementation values. There were no significant differences in the mean values of AC, WHR, triglyceride, lowdensity lipoprotein cholesterol LDL-C, high-density lipoprotein cholesterol HDL-C, and GSH post-intervention. The study concluded that dry pomegranate could be used for the prevention of lipid peroxidation and to enhance antioxidant status in patients.