Effect of dietary lipids on paraoxonase-1 activity and gene expression

Ferretti, Gianna; Bacchetti, Tiziana

doi:10.1016/j.numecd.2011.08.011

Cited by 44 publications

(27 citation statements)

References 55 publications

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“…Interestingly, these improvements are accompanied by an increase in PON1 activity (Helal et al 2013). Other studies have reported that diets rich in monounsaturated fatty acids (MUFA) are associated with an increase in PON1 activity (Ferretti et al 2012). In terms of RCT, Treguier et al reported that the efflux of cholesterol from macrophages to plasma D r a f t as well as in vivo RCT are significantly impaired in hamsters fed a cholesterol-enriched diet (Treguier et al 2011).…”

Section: Hdl Functionality and Dietmentioning

confidence: 99%

The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging

Khalil

Simo

Ikhlef

et al. 2017

Can. J. Physiol. Pharmacol.

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Pharmacological interventions to increase the concentration of high-density lipoprotein (HDL) have led to disappointing results and have contributed to the emergence of the concept of HDL functionality. The anti-atherogenic activity of HDLs can be explained by their functionality or quality. The capacity of HDLs to maintain cellular cholesterol homeostasis and to transport cholesterol from peripheral cells to the liver for elimination is one of their principal anti-atherogenic activities. However, HDLs possess several other attributes that contribute to their protective effect against cardiovascular diseases. HDL functionality is regulated by various proteins and lipids making up HDL particles. However, several studies investigated the role of paraoxonase 1 (PON1) and suggest a significant role of this protein in the regulation of the functionality of HDLs. Moreover, research on PON1 attracted much interest following several studies indicating that it is involved in cardiovascular protection. However, the mechanisms by which PON1 exerts these effects remain to be elucidated.

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Section: Hdl Functionality and Dietmentioning

confidence: 99%

The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging

Khalil

Simo

Ikhlef

et al. 2017

Can. J. Physiol. Pharmacol.

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“…Dietary fats have been suggested as an important relevant factor [12, 13]. Studies have presented that dietary fatty acids may affect PON1 activity [14].…”

Section: Introductionmentioning

confidence: 99%

Serum Paraoxonase 1 Activity Is Associated with Fatty Acid Composition of High Density Lipoprotein

et al. 2013

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Introduction. Cardioprotective effect of high density lipoprotein (HDL) is, in part, dependent on its related enzyme, paraoxonase 1 (PON1). Fatty acid composition of HDL could affect its size and structure. On the other hand, PON1 activity is directly related to the structure of HDL. This study was designed to investigate the association between serum PON1 activity and fatty acid composition of HDL in healthy men. Methods. One hundred and forty healthy men participated in this research. HDL was separated by sequential ultracentrifugation, and its fatty acid composition was analyzed by gas chromatography. PON1 activity was measured spectrophotometrically using paraxon as substrate. Results. Serum PON1 activity was directly correlated with the amount of stearic acid and dihomo-gamma-linolenic acid (DGLA). PON1/HDL-C was directly correlated with the amount of miristic acid, stearic acid, and DGLA and was inversely correlated with total amount of ω6 fatty acids of HDL. Conclusion. The fatty acid composition of HDL could affect the activity of its associated enzyme, PON1. As dietary fats are the major determinants of serum lipids and lipoprotein composition, consuming some special dietary fatty acids may improve the activity of PON1 and thereby have beneficial effects on health.

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“…PON is along with ApoA-I in HDL-C and prevents LDL-C oxidation in vitro and in arterial wall. This mechanism describes the relationship between HDL, lipoprotein oxidation, and atherosclerosis [26]. At the end of this study, PON-1 was reduced nonsignificantly in both groups.…”

Section: Discussionmentioning

confidence: 58%

“…High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation for myocardial infarction prediction [25]. Paraoxonase-1 (PON-1) that is located on HDL-C can prevent peroxidation of LDL-C particles and may lead to reduce atherosclerosis risk [26]. Apo-protein B (ApoB) is associated with more LDL-C and cardiovascular risk, whereas Apoprotein A-I (ApoA-I) as a specific marker of HDL-C, is associated with lower risk of atherosclerosis [27].…”

Section: Introductionmentioning

confidence: 99%

Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia

Shidfar

Amani

Vafa

et al. 2015

Biol Trace Elem Res

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Numerous studies have demonstrated that tissue deposition of iron following prolonged high dose of oral supplementation for treatment of iron deficiency anemia (IDA) leads to body iron overload and oxidative stress, which starts the process of atherosclerosis. This study aimed to determine the effect of iron supplementation in combination with docosahexaenoic acid (DHA) on the cardiovascular disease risk based on paraoxonase-1 (PON-1), high-sensitivity C-reactive protein (hs-CRP), and ApoB/ApoA-I ratio in women with IDA. In this randomized controlled trial, 76 women with IDA, aged 15-45 years, were included. The patients were randomly assigned to receive 500 mg of DHA supplement or placebo with an iron tablet, once daily for 12 weeks. The participants were assessed by measurement of the serum iron, ferritin, PON-1, hs-CRP levels, and the ApoB/ApoA-I ratio at the beginning and end of study. Serum hs-CRP decreased in the DHA-supplemented group (p = 0.036), and ApoA-I decreased in the placebo group (p = 0.013). No significant difference was detected for the serum PON-1 concentration and the ApoB/ApoA-I ratio in two groups. Iron supplementation combined with DHA may have favorable effects on serum hs-CRP in women with IDA.

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Effect of dietary lipids on paraoxonase-1 activity and gene expression

Cited by 44 publications

References 55 publications

The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging

The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging

Serum Paraoxonase 1 Activity Is Associated with Fatty Acid Composition of High Density Lipoprotein

Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia

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