Effect of dietary milk thistle (Silybum marianum L.) oil supplementation on animal performance and milk fatty acid composition in dairy ewes

Karaiskou, C.; Kasapidou, E.; Michailidis, Georgios; Markantonatos, X.; Basdagianni, Zoitsa

doi:10.1016/j.smallrumres.2021.106493

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…About 60% of the world’s population uses folklore medicines derived from medicinal plants (Modak et al, 2007). S. marianum has been reported as one of the most important medicinal herbs used in the present times (Karaiskou et al, 2021). Phytochemicals play a significant role in the treatment of different diseases and are used in both traditional and modern systems of medication (Ali et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.) Gaertn. (Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced Diabetes in Rats

Maaliah,

Haddadin,

Abdalla

2024

Pharmacognosy Magazine

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Background: Metabolic syndrome (MS) is considered a challenging health problem worldwide. However, the search for alternative treatments to alleviate MS is lacking. Purpose: This study defines Silybum marianum (milk thistle) ethanol seed extract (SMESE) in terms of polyphenol and flavonoid content, antiglycation effect, α-amylase activity, and hypolipidemic and hypoglycemic effects in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: S. marianum seeds were collected, ground, and extracted with 80% ethanol. The α-amylase inhibitory activities of 10, 30, and 100 µg/mL SMESE were evaluated using spectrophotometric methods. The inhibitory activity of SMESE against advanced glycation end-product formation was evaluated using fluorescence spectrophotometry. In vivo, 48 Wistar male albino rats were used. Eight animals served as the normal control (group 1), and 40 rats were injected with 60 mg/kg STZ to induce diabetes. Diabetic rats were divided into five groups: diabetic control (group 2) and positive control that received the hypoglycemic reference drug metformin at 100 mg/kg (group 3). Groups 4, 5, and 6 were administered the seed extract orally at 30, 100, and 300 mg/kg, respectively. Body weight, serum glucose, lipid profile, and malondialdehyde (MDA) levels were measured weekly for five weeks after SMESE administration. Results: SMESE administration inhibited BSA glycation and α-amylase activity. In vivo, SMESE administration increased body weight (BW), decreased serum glucose levels, and reduced triglyceride, total cholesterol, low-density lipoprotein, very low-density lipoprotein, and MDA levels but increased high-density lipoprotein levels. Conclusion: Data indicate the beneficial hypoglycemic and antihyperlipidemic effects of SMESE, suggesting its potential use in controlling lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.) Gaertn. (Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced Diabetes in Rats

Maaliah,

Haddadin,

Abdalla

2024

Pharmacognosy Magazine

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“…Supplementing the fattener diet of pigs with milk thistle seed increased the body weight gain and enhanced meat color, texture, water-holding capacity, and oxidative capacity, while it increased polyunsaturated fatty acid (PUFA) [8]. Karaiskou et al [9] also observed that supplementing milk thistle oil in ewe's diet translated into higher daily milk yield and enhanced its nutrient value by increasing its composition of monounsaturated fatty acids and PUFA and lowering saturated fatty acid content.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Evaluation of Milk Thistle Meal as a Protein Feedstuff for Diets of Dairy Cattle

Lambo,

Liu,

Zhang

et al. 2024

Animals

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The objective of this work is to investigate the chemical and nutritional value of milk thistle meal (MTM) in order to improve it and to provide theoretical support for its application in dairy cattle production. MTM was assessed in comparison with seven conventional protein feed sources, namely, soybean meal (SBM), cottonseed meal (CS), canola meal (CN), palm kernel meal (PK), rice bran meal (RB), corn germ meal (CG), and sesame meal (SS). The chemical composition of these feedstuffs was assessed using wet chemical analysis, the Cornell Net Carbohydrate and Protein System was used to evaluate the carbohydrate and protein fractions, and the in situ nylon bag technique and the modified three-step in vitro method were used to assess the rumen degradation and intestinal digestibility. Additionally, Fourier transform infrared technology was used to determine the feedstuff protein spectral molecular structure and its amino acid profile was also assessed. The result showed that MTM acid detergent fiber, lignin, unavailable nitrogen, and non-degradable carbohydrate content were higher than those of the other feedstuffs. It had a 17% and 36% rumen effective degradation rate of neutral detergent fiber and dry matter, respectively, and had the lowest small intestinal rumen undegradable protein digestibility rate. It was low in leucine, histidine, arginine, and proline, but high in methionine. The total area of amide I and amide II in the protein secondary structure was similar to that of CN and CS, and the amide I and II ratio was not different from that of RB. To sum up, MTM has a poor carbohydrate composition and is high in fiber but, in comparison to most other protein feeds, has a higher crude protein rumen effective degradation rate, similar to that of SBM, and it is a good source of methionine, a limiting amino acid. Hence, its nutritional value can be further improved for application in dairy feeding through processes such as microbial or enzymatic fermentation.

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Effect of milk thistle (Silybum marianum L.) oil on pro-inflammatory cytokines, acute phase proteins, rumen metagenomic profile, rumen fluid variables and performance in calves

Kara,

Pi̇rci̇,

Yılmaz Öztaş

et al. 2024

Vet Res Commun

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Effect of dietary milk thistle (Silybum marianum L.) oil supplementation on animal performance and milk fatty acid composition in dairy ewes

Cited by 5 publications

References 33 publications

Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.) Gaertn. (Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced Diabetes in Rats

Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.) Gaertn. (Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced Diabetes in Rats

Nutritional Evaluation of Milk Thistle Meal as a Protein Feedstuff for Diets of Dairy Cattle

Effect of milk thistle (Silybum marianum L.) oil on pro-inflammatory cytokines, acute phase proteins, rumen metagenomic profile, rumen fluid variables and performance in calves

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