Effect of Dietary n-3/n-6 Fatty Acid Ratio on the Total Count, Fatty Acid Composition, and Histamine and Leukotriene Concentrations of Mast Cells in Tunica Mucosa Bronchiorum of Type I Allergic Guinea Pig

Kuwamori, Masanori; Wada, Masahiro; Takita, Toshichika; Tadokoro, Tadahiro; Maekawa, Akio; Innami, Satoshi

doi:10.1271/bbb.61.763

Cited by 11 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the effector phase, PUFAs (n-3 alone or in varying ratios to n-6) have been shown to reduce histamine and leukotriene B4 levels when supplemented to mast cells (MCs) (34, 35). However, n-6 PUFA AA has been shown to activate intracellular ROS production, increase MC degranulation mediated by IgE, and TNF-α and PGD 2 release (36, 37).…”

Section: Immunomodulation By Pufas In Food Allergymentioning

confidence: 99%

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

et al. 2019

View full text Add to dashboard Cite

N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An “inflammation-suppressive” effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as (food) allergy. LCPUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy in pre-clinical models. In this review, we explore the anti-allergic properties of LCPUFAs by providing an overview of clinical, in vivo and in vitro studies. Furthermore, we discuss the susceptibility of LCPUFAs to lipid oxidation and possible strategies to support the efficacy of LCPUFAs in reducing the allergy risk by using additional components with anti-oxidative and anti-inflammatory capacities such as the flavonoid quercetin. Finally, we propose new strategies to prevent (food) allergy using combinations of LCPUFAs and additional nutrients in diets or supplements, and postulate to investigate the use of LCPUFAs in allergic symptom relief.

show abstract

Section: Immunomodulation By Pufas In Food Allergymentioning

confidence: 99%

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The physiological balance between concentrations of (n-6) and (n-6) fatty acids maintains lower synthesis of proinflammatory cytokines (33-37) (mainly IL-1b and TNF-a), lower synthesis of prostaglandins, leukotrienes, and phosphodiesterase type 4 (38,39). When there is low concentration of the (n-3) PUFA, the increase in tissue inflammation can lead to cAMP cleavage, lower levels of cAMP response element binding factor, and brain-derived neurotrophic factor, which reduces synaptic plasticity and neurotransmission and increases neuron damage and death (40).…”

Section: (N-3) Fatty Acids In Cytosolic Pathwaysmentioning

confidence: 99%

(N-3) Fatty Acids: Molecular Role and Clinical Uses in Psychiatric Disorders

Prior¹,

Galduróz

2012

Advances in Nutrition

View full text Add to dashboard Cite

New discoveries in the field of neurophysiology and neuropharmacology have revealed the role of (n-3) fatty acids in controlling inflammation and protecting neuron cells from oxidative damage, preserving their function. It has also been thought that their psychoactive properties could be beneficial in certain psychiatric illnesses. This article discusses the newest discoveries of the affected activities by these fats in the cerebral cortex and the efforts that have been made to put them in practice in clinical trials in humans. In general, we were able to detect certain discord in the scientific community when designing placebo-based studies (mainly in establishing the appropriate therapeutic dose of (n-3) fatty acids, varying from the recommended dietary dose to an amount that may be 3 or 4 times higher), and in interpreting results. Although many studies have had the validity of their results questioned because of their small sample size, several studies seem to indicate that the (n-3) fatty acids are useful therapeutic tools in treating psychiatric conditions such as major depression, bipolar disorder, and several other disorders. Larger sample size studies are still required to better analyze the treatment potential of these agents.

show abstract

“…Lee et al 5) reported that a ratio of about 4-5 is desirable based on eicosanoid production and tissue fatty acid composition patterns in rats. Yamada et al 7) reported that the ratio should be adjusted to 2-5 based on the inhibition of platelet aggregation in rats, and Kuwamori et al 29) reported that the ratio should be lowered to about 1 to inhibit allergic reactions. The optimal ratio may vary depending on the indices 30,31) .…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary n-6/n-3 Ratio on Liver n-6/n-3 Ratio and Peroxisomal .BETA.-Oxidation Activity in Rats

et al. 2008

View full text Add to dashboard Cite

The optimal dietary n-6/n-3 ratio has not been fully elucidated. To investigate the influence of the dietary n-6/n-3 ratio on this ratio in the body and on liver b-oxidation peroxisomal activity, rats were fed diets containing fat at an n-6/n-3 ratio of 1 to 16 for 4 weeks. To investigate whether elevation of the liver peroxisomal b-oxidation activity increases the n-6/n-3 ratio in the body, rats were fed a diet containing a peroxisome-activating agent, bezafibrate, for 2 weeks, and its influence on the liver n-6/n-3 ratio was examined. The slope of the regression line between the dietary and liver total lipid n-6/n-3 ratios was significantly smaller when the dietary n-6/n-3 ratio was 4 or greater than when it was smaller than 4. Peroxisomal b-oxidation and acyl CoA oxidase activities were significantly lower in rats fed a diet with an n-6/n-3 ratio of 16 than in those fed a diet with a ratio of 1. The peroxisomal b-oxidation activity in the bezafibrate-supplemented group was significantly higher than that in the control group. The serum and liver total lipid n-6/n-3 ratios were significantly higher in the 0.015% bezafibrate-supplemented group than in the control group. These findings suggest that the liver n-6/n-3 ratio might be controlled via peroxisomal b-oxidation in rats.

show abstract

Effect of Dietary n-3/n-6 Fatty Acid Ratio on the Total Count, Fatty Acid Composition, and Histamine and Leukotriene Concentrations of Mast Cells in Tunica Mucosa Bronchiorum of Type I Allergic Guinea Pig

Cited by 11 publications

References 8 publications

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

(N-3) Fatty Acids: Molecular Role and Clinical Uses in Psychiatric Disorders

Effect of Dietary n-6/n-3 Ratio on Liver n-6/n-3 Ratio and Peroxisomal .BETA.-Oxidation Activity in Rats

Contact Info

Product

Resources

About