Effect of dietary nucleotide supplementation on broiler intestinal  histomorphology

Khedr, Nasser; Ahmed, Tahia; Nagiub, Sarah Mohammed

doi:10.21608/bvmj.2020.49900.1295

Cited by 5 publications

(5 citation statements)

References 13 publications

(28 reference statements)

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“…By significantly, Table 6 demonstrates that intestinal morphology in nucleotide-fed groups is significantly improved when compared to control groups, especially when combined with PUFA oil sources (FO, LO, then SBO). These findings were in agreement with those of Khedr et al (44), who demonstrated that, in the jejunum region of the small intestine, broiler groups fed nucleotides showed a substantial increase in intestinal villi length when compared to control groups. And yet, Hassanein et al (38) found that fish oil-based diets significantly improved intestinal morphology compared to control groups in terms of villus height, crypt depth, mucosal thickness, wall thickness, villus width, villus perimeter, and villus surface area.…”

Section: Effects Of Nucleotides Dietary Supplement On Intestinal Morp...supporting

confidence: 93%

Effects of Dietary Nucleotides Supplementation on the Perfor-Mance of Broiler Chicks

Hassanein

Metwally²,

Elbaky³

2023

SVR

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This study examined the effects of nucleotide supplementation on broiler chick growth performance, immunological response, carcass traits, meat quality, serum biochemical parameters, total antioxidant capacity, intestinal morphology, mortality rate, and economic efficiency measures of broiler chicks. A total of 180 one-day-old chicks (Ross 308) were distributed into 6 groups, each of which consisted of 30 chicks, and each group was divided into 3 replicates so that each replicate contained 10 chicks fed on six experimental diets as follows: basal diet without oil or nucleotide (T1), basal diet with 1% soybean oil and without nucleotide(T2), 50 grams nucleotide per 100-kilogram diet with different fat sources (no oil(T3), 1% soybean oil(T4), 1% linseed oil(T5) &1% fish oil(T6) respectively during the experimental period (5 weeks). Growth performance parameters were detected per stage period. Four chicks from each replicate were used at the termination of the experiment for analysis of the above mentioned measurements. Results revealed that supplementation of nucleotide in diets of broiler chicks improved feed conversion ratio, carcass traits, intestinal morphology, serum biochemical parameters, immunological response, bursa of Fabricius weight, and the best ratios were observed in groups fed nucleotide in combination with fish and linseed oil. Also, there was an increased economic efficiency in the SBO fed group(T2) then group fed nucleotides in mix with linseed oil (T5) and control (T1). In comparison to the control groups (T1 & T2), groups fed nucleotides and PUFA oil sources had significantly lower n-6: n-3 ratio in breast muscle, and mortality rate.

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Section: Effects Of Nucleotides Dietary Supplement On Intestinal Morp...supporting

confidence: 93%

Effects of Dietary Nucleotides Supplementation on the Perfor-Mance of Broiler Chicks

Hassanein

Metwally²,

Elbaky³

2023

SVR

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“…These goblet cells secrete mucin, which dissolves in water to create mucus, which coats the gut wall and functions as a first line of defense against pathogen invasion, implying a beneficial effect of nucleotide supplementation on intestinal health status. These findings came in harmony withKhedr et al (2020b),Kamel et al (2021) andRady et al (2023) who returned the cause of improvement in growth performance after nucleotides inclusion to the increased villi length and increased number of intestinal glands which in turn led to increasing the surface area of absorption and consequently increased digestion and absorption of nutrient.…”

supporting

confidence: 75%

Dietary Nucleoforce® supplementation improves growth performance, feed efficiency and enhances intestinal morphology in broiler chickens

Abd El Rahman,

Ismail,

shousha

et al. 2023

Benha Veterinary Medical Journal

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This study was carried out to estimate the effect of nucleoforce® on growth performance, feed efficiency and intestinal morphometry in broiler chickens. Two hundred forty, one-day old Ross 308 broiler chicks were randomly allocated into four equal groups (60birds for each group)with 3 replicates(20 birds for each replicate).Birds in the first group fed diet with no supplementation and considered as a control group (C),whereas birds of the second (200N), third (350N), and fourth (500N) groups were fed diet supplemented with nucleoforce® at concentrations of (200, 350 and 500 g/ton, respectively) from zero day till the end of the experiment. Birds were weighed weekly to record their body weight then calculate their weight gain and relative growth rate. Feed consumption was daily estimated and feed conversion rate was calculated. At days 21 and 49, intestinal samples (jejunum) were subjected to quantitative morphometrical analysis. The obtained results revealed improvement ingrowth parameters and enhancement of histomorphology of jejunum of small intestine in broiler chickens after dietary nucleoforce® supplementation. It could be concluded that dietary nucleoforce® as a commercial source of nucleotides can be considered as a promising feed additive in broiler chickens.

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“…Adding nucleotides to the diet optimizes the overall body weight gain (BWG), improves feed consumption and absorption, and results in better feed conversion ratio . Khedr and Ahmed (2020) have depicted that a nucleotide-added diet has achieved more beneficial economic outputs per kg body weight in chickens. Wu et al (2018) showed that nucleotide supplementation resulted in an immediate and potent immune response to routine vaccination in poultry.…”

Section: Dietary Nucleotidesmentioning

confidence: 99%

Nutritional Supplements for the Control of Avian Coccidiosis – A Review

Alsayeqh

Abbas

2023

Annals of Animal Science

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Coccidiosis is acclaimed as the most prevalent enteric parasitic ailment of poultry. It is caused by an apicomplexan protozoon of the genus Eimeria, which resides in chicken intestinal epithelium leading to intestinal damage. As a result, bloody droppings are there, feed efficiency is reduced, the growth rate is impaired, and egg production is temporarily decreased. Treatment and prevention of coccidiosis are primarily accomplished by inoculating live vaccines and administering anticoccidial drugs. Due to anticoccidials’ continuous and excessive use, the mounting issue is drug resistant Eimeria strains. The poultry industry has managed resistance-related issues by suggesting shuttle and rotation schemes. Furthermore, new drugs have also been developed and introduced, but it takes a long time and causes cost inflation in the poultry industry. Moreover, government disallows growth promoters and drugs at sub-therapeutic doses in poultry due to increased concerns about the drug residues in poultry products. These constraints have motivated scientists to work on alternative ways to control coccidiosis effectively, safely, and sustainably. Using nutritional supplements is a novel way to solve the constraints mentioned above. The intriguing aspects of using dietary supplements against coccidiosis are that they reduce the risk of drug-resistant pathogen strains, ensure healthy, nutritious poultry products, have less reliance on synthetic drugs, and are typically considered environmentally safe. Furthermore, they improve productivity, enhance nonspecific immunity, preventing oxidation of fats (acting as antioxidants) and inflammation (acting as an anti-inflammatory). The present manuscript focuses on the efficacy, possible mechanism of action, applications, and different facets of nutrition supplements (such as organic acids, minerals, vitamins, probiotics, essential oils, amino acids, dietary nucleotides, feed enzymes, and yeast derivatives) as feed additive for treating poultry coccidiosis.

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Effect of dietary nucleotide supplementation on broiler intestinal histomorphology

Cited by 5 publications

References 13 publications

Effects of Dietary Nucleotides Supplementation on the Perfor-Mance of Broiler Chicks

Effects of Dietary Nucleotides Supplementation on the Perfor-Mance of Broiler Chicks

Dietary Nucleoforce® supplementation improves growth performance, feed efficiency and enhances intestinal morphology in broiler chickens

Nutritional Supplements for the Control of Avian Coccidiosis – A Review

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