Effect of dietary oxidized tyrosine products on insulin secretion via the oxidative stress-induced mitochondria damage in mice pancreas

Ding, Yin‐Yi; Cheng, Xiang‐Rong; Li, Zhu-Qing; Wu, Sha-Ji; Yang, Yuhui; Shi, Yonghui; Li, Guowei

doi:10.1039/c7ra02945d

Cited by 25 publications

(48 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particular protein oxidation products, such as protein carbonyls, the α‐amino adipic acid, tyrosine, tryptophan, and phenylalanine oxidation products, among others, initially exposed to the intestinal mucosa, are absorbed and hence, accumulate in the epithelium and may be distributed to distant internal organs through the bloodstream (Ding, Cheng et al., , Ding, Li et al., ; Wang et al., ; Yang, Zhang et al., , Yang, Yan et al., ). The intestinal uptake of specific protein oxidation products after oral administration, and the subsequent organic accumulation proves the bioavailability and bioactivity of these species which seem to have certain tropism for target tissues.…”

Section: Dietary Protein Oxidation and Oxidative Stressmentioning

confidence: 99%

“…The intestinal uptake of specific protein oxidation products after oral administration, and the subsequent organic accumulation proves the bioavailability and bioactivity of these species which seem to have certain tropism for target tissues. This is the case of protein carbonyls for the intestinal epithelium (Keshavarzian et al., ), the α‐amino adipic acid for pancreas (Wang et al., ), and oxidized tyrosines for pancreas, kidney and liver (Ding, Cheng et al., ; Ding, Li et al., ; Ding, Tang et al., ; Yang, Zhang et al., , Yang, Yan et al., ). Finally, it is worth noting that the elevation of protein oxidation markers in blood and tissues may not only be caused by the intake of such species.…”

Section: Dietary Protein Oxidation and Oxidative Stressmentioning

confidence: 99%

“…Ding, Cheng et al. () provided Sprague Dawley (SD) rats with dietary oxidized tyrosine (2 to 8 g/kg diet/day) for 24 weeks. The dysfunction of the pancreatic islets was reflected in elevated fasting blood glucose and decreased plasma insulin levels.…”

Section: Pathogenesis Of Dietary Protein Oxidation: Recent Advancesmentioning

confidence: 99%

See 2 more Smart Citations

Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses

Estévez

Xiong

2019

Journal of Food Science

116

View full text Add to dashboard Cite

The exposure to reactive oxygen species (ROS) is an inevitable consequence of living in an aerobic world. The species contribute to the occurrence of oxidative stress in humans in which an uncontrolled production of ROS exceeds the endogenous antioxidant defences leading to the oxidative damage to essential cellular components, such as lipids, proteins, and DNA. The influence of diet on the modulation of the systemic redox status is recognized and, while some dietary components are found to be protective (that is, fruits and vegetables), others are recognized as pro‐oxidants (that is, processed meat and other animal‐source protein foods). Oxidized proteins and amino acids are potential promoters of luminal and postprandial oxidative stress; preliminary studies have actually reported noxious effects of these species in cultured cells and in experimental animals. However, the underlying pathological mechanisms remain poorly understood. The application of advanced methodological approaches based on mass spectrometric technologies and OMICS disciplines has enabled the elucidation of the molecular basis of the pathological effects of dietary oxidized proteins and amino acids. The present review collects the most recent evidences of the health risks of dietary protein oxidation and proposes reasonable hypotheses and future perspectives on the field.

show abstract

Section: Dietary Protein Oxidation and Oxidative Stressmentioning

confidence: 99%

Section: Dietary Protein Oxidation and Oxidative Stressmentioning

confidence: 99%

See 1 more Smart Citation

Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses

Estévez

Xiong

2019

Journal of Food Science

116

View full text Add to dashboard Cite

show abstract

“…These tests generally include a minimum or maximum values for protein, moisture, or fat. Whereas studies examining dietary oxidized protein in broilers and rodents have shown decreased organ and immune function, the risks to livestock or companion animals that consume oxidized lipids and proteins are not well defined ( Wu et al, 2014 ; Li et al, 2016 ; Ding et al, 2017 ; Estévez and Luna, 2017 ; Yang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of storage conditions on protein oxidation of rendered by-product meals1

Frame

Huff-Lonergan

Serao

2020

Translational Animal Science

View full text Add to dashboard Cite

Rendered products used in animal feed and pet food undergo extreme temperatures during manufacturing and may be stored up to two years. No information is available on protein oxidation in these products. The objective of this study was to determine the extent to which typical antioxidant inclusion at different storage conditions may limit protein oxidation in typical rendered protein meals. Two experiments were conducted on 14 rendered products stored at either 45°C for 7 or 14 days, or at 20°C for 3 or 6 months to determine the extent to which time, temperature, and antioxidants affect protein oxidation. Results from this study show that fish meal and chicken blood meal are susceptible to protein oxidation during storage at 45°C (P = 0.05; 0.03) as well as during storage at 20°C (P = 0.01; 0.04). Natural antioxidants were effective at limiting carbonyl formation in fish meal during short term storage at 45°C whereas ethoxyquin was effective at limiting the extent of protein oxidation in fish meal stored long term at 20°C.

show abstract

“…and immune function. [16][17][18][19] These possible implications justify the need to understand how extrusion can impact protein oxidation.…”

Section: Studies Examining Dietary Oxidized Protein In Broilers and Rmentioning

confidence: 99%

Investigations of the oxidative stability of rendered protein meals and their suitability as feed ingredients

Frame¹

View full text Add to dashboard Cite

show abstract

Effect of dietary oxidized tyrosine products on insulin secretion via the oxidative stress-induced mitochondria damage in mice pancreas

Abstract: The findings suggested that decreased insulin secretion triggered by OTPs may be mediated by oxidative stress and mitochondrial damage in pancreatic β cells.

Cited by 25 publications

References 63 publications

Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses

Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses

Impact of storage conditions on protein oxidation of rendered by-product meals1

Investigations of the oxidative stability of rendered protein meals and their suitability as feed ingredients

Contact Info

Product

Resources

About