Effect of Dietary Protein Restriction on Chromatin Proteins of Rat Mammary Gland

Ravi, Revathi; Ganguli, N. C.

doi:10.1093/jn/110.6.1144

Cited by 12 publications

(3 citation statements)

References 25 publications

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“…Under these conditions, milk production and protein synthesis per mammary cell were altered by treatment. These observations and other recent reports (23)(24)(25) suggest that some dietary deficiencies impair lactation by altering mam-mary cellularity, whe reas ot he r deficiencies alt er per-cell ac tivity without affec ting mammary cell numb er.…”

Section: Discussionsupporting

confidence: 76%

The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat

Sampson,

Jansen

1985

J. pediatr. gastroenterol. nutr.

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Protein synthesis was studied in mammary tissue of rats fed diets deficient in protein quality and/or restricted in food intake throughout gestation and lactation. Diets containing 25% wheat gluten (WG), wheat gluten plus lysine and threonine (WGLT), or casein (C) were pair‐fed from conception until day 15 of lactation at 100% or 85% of WG ad libitum consumption (PF100 and PF85, respectively). A seventh group was fed C ad libitum. Rates of protein synthesis were measured in vivo at day 15 of lactation from incorporation of [3‐3H]phenylalanine. At both PF100 and PF85, fractional and absolute rates of mammary gland protein synthesis were two‐ to three‐fold higher in rats fed C than in those fed WG. Pup weights showed similar treatment effects. Both mammary protein synthesis rates and pup weights were significantly higher in rats fed C at PF85 than rats fed WG ad libitum. Food restriction from PF100 to PF85 depressed pup weights and mammary protein synthesis rates in rats fed WGLT, but had no effect in rats fed WG. These results demonstrate that when food intake is restricted, improvement of protein quality of the maternal diet increases milk output in the rat in association with increased rates of mammary protein synthesis.

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Section: Discussionsupporting

confidence: 76%

The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat

Sampson,

Jansen

1985

J. pediatr. gastroenterol. nutr.

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“…Lysine deficiency (12) and a protein-free diet (17) increase the mass ratio of nonhistone protein to DNA in liver chromatin, while the ratio of histone to DNA remains unchanged. However, a 5% casein diet significantly decreases the mass ratio of nonhistones to DNA, compared with a 20% casein diet (74).…”

Section: Nutrient Ejfects'on Nuclear Proteinsmentioning

confidence: 87%

Nutrient Effects on DNA and Chromatin Structure

Castro¹

1987

Annu. Rev. Nutr.

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“…It is known that nuclear proteins play an important role in the maintenance of the structural and functional organization of the eukaryotic genome. The composition of those proteins changes according to the genotype (T allman et al 1979; B erdnikov 1981; L uboń et al 1982) and the functional condition of cells and tissues (S ziklai et al 1981; R avi and G anguli 1980).…”

Section: Introductionmentioning

confidence: 99%

The nuclear proteins in the liver of rabbits with an inherited motorial failure

Pałyga

Zelník

Luboń

et al. 1985

J Animal Breeding Genetics

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Summary The composition and electrophoretic patterns of nuclear sap and chromatin proteins from the liver of normal and genetically immobilized rabbits were compared. It was found that RNA content and the amount of some nonhistone proteins changed in defective animals. These variations may result from genetic differences between normal rabbits and rabbits with an inborn motorial insufficiency or may appear in consequence of the effect of limb paresis on the liver metabolism. Zusammenfassung Die Kernproteine in der Leber von Kaninchen mit genetischem Bewegungsdefekt Die Zusammensetzung und das elektrophoretische Muster des Kernsaftes und der Kernproteine aus der Leber normaler und genetisch immobilisierter Kaninchen werden verglichen. Es zeigt sich, daß der RNS‐Gehalt und die Menge einiger Nicht‐Histonproteine in defekten Tieren sich geändert hat. Diese Variabilität kann von genetischen Unterschieden zwischen normalen und Kaninchen mit angeborener Bewegungsinsuffizienz herrühren oder kann eine Folge der Wirkung der Lähmung der Extremitäten auf den Lebermetabolismus darstellen. Résumé Les protéines nucléaires dans le foie de lapins avec défaut moteur génétique Les auteurs ont comparés la composition et le modèle éléctrophorétique du suc nucléaire et des protéines nucléaires du foie de lapins normaux et génétiquement immobilisés. On a observé que la teneur ARN et la quantité de quelques protéines non‐histones changeaient dans les animaux défectifs. Ces variabilités peuvent résulter des différences génétiques entre lapins normaux et lapins avec insuffisance motrice congénitale ou peuvent représenter la suite de l'effet de paralysie des extrémités sur le métabolisme du foie. Resumen Proteínas nucleares en el hígado del conejo con defectos genéticos motores Fueron comparadas la composición y los patrones electroforeticos de proteínas nucleares del fluido y cromatina desde el hígado de conejos normales y conejos geneticamente paralíticos. Fue encontrado que el contenido de RNA y la cantidad de algunas proteínas no‐histonas, cambían en los animales con el defecto. Esta variabilidad puede resultar de las diferencias genéticas en los conejos normales y conejos con insuficiencia motora al nacimiento o puede aparecer como consecuencia del efecto paralítico en las extremidades debido al metabolismo hepático.

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Effect of Dietary Protein Restriction on Chromatin Proteins of Rat Mammary Gland

Cited by 12 publications

References 25 publications

The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat

The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat

Nutrient Effects on DNA and Chromatin Structure

The nuclear proteins in the liver of rabbits with an inherited motorial failure

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