Effect of Dietary Protein Supplementation on Blood Pressure

He, Jiang; Wofford, Marion R.; Reynolds, Kristi; Chen, Jing; Chen, Chung Shiuan; Myers, Leann; Minor, Deborah L.; Elmer, Patricia J.; Jones, Daniel W.; Whelton, Paul K.

doi:10.1161/circulationaha.110.009159

Cited by 84 publications

(46 citation statements)

References 33 publications

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“…The Protein and Blood Pressure Study was a randomized, double-blinded and placebo-controlled trial designed primarily to test whether a soy protein or milk protein supplementation would reduce systolic blood pressure (BP) compared with a complex carbohydrate and secondarily to assess the impact of these supplements on serum lipids and lipoproteins (He et al, 2011). The Protein and Blood Pressure study utilized a 3-phase crossover study design.…”

Section: Methodsmentioning

confidence: 99%

Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial

et al. 2011

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Background/Objective: Previous clinical trials have documented that soy protein reduces low-density lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol compared with milk protein. However, the effect of soy protein on lipids compared with carbohydrate has not been not well studied. We examined the effect of soy and milk protein supplementation on lipids and lipoproteins compared with carbohydrate among adults without hypercholesterolemia. Subjects/Methods: We conducted a randomized, double-blind, 3-phase crossover trial among 352 US adults with serum total cholesterol level of o240 mg/dl from September 2003 to April 2008. Trial participants were assigned to 40 g/day supplementation of soy protein, milk protein or complex carbohydrate from wheat each for 8 weeks in random order with a 3-week washout period between interventions. Overnight fasting blood samples were collected at the termination of each intervention phase. Results: Compared with carbohydrate, soy protein supplementation was significantly associated with a net change (95% confidence interval (CI)) in total cholesterol and total/HDL cholesterol ratio of À3.97 mg/dl (À7.63 to À0.31, P ¼ 0.03) and À0.12 (À0.23 to À0.01, P ¼ 0.03), respectively. Compared with milk protein, soy protein supplementation was significantly associated with a net change (95% CI) in HDL and total/HDL cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P ¼ 0.0009) and À0.14 (À0.22 to À0.05, P ¼ 0.001), respectively. Compared with carbohydrate, milk protein supplementation was significantly associated with a net change (95% CI) in HDL of À1.13 mg/dl (À2.05 to À0.22, P ¼ 0.02). Conclusions: This randomized controlled trial indicates that soy protein, but not milk protein, supplementation improves the lipid profile among healthy individuals.

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Section: Methodsmentioning

confidence: 99%

Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial

et al. 2011

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“…Increased dietary protein intake is inversely associated with risk for stroke in women with hypertension [99] . A randomized cross-over study in 352 adults with pre-hypertension and stage Ⅰ hypertension found a significant reduction in SBP of 2.0 mmHg with soy protein and 2.3 mmHg with milk protein compared to a high glycemic index diet over each of the 8 wk treatment periods [100] . There was a non-significant reduction in DBP.…”

Section: Proteinmentioning

confidence: 99%

“…Milk peptides which contain both caseins and whey proteins are a rich source of ACEI peptides. Val-Pro-Pro and Ile-Pro-Pro given at 5 to 60 mg/d have variable reductions in BP with an average decrease in pooled studies of about 1.28-4.8/0.59-2.2 mmHg [71,100,[104][105][106][107] . However several recent meta-analysis did not show significant reductions in BP in humans [106,108] .…”

Section: Proteinmentioning

confidence: 99%

“…A similar study with a vegetable drink with sardine protein hydrolysates significantly lowered BP by 8/5 mmHg in 13 wk [118] . Soy protein lowers BP in hypertensive patients in most studies [100,[119][120][121][122][123][124][125][126][127] . Soy protein intake was significantly and inversely associated with both SBP and DBP in 45694 Chinese women consuming 25 g/d or more of soy protein over 3 years and the association increased with age [119] .…”

Section: Proteinmentioning

confidence: 99%

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The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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“…Thus, partially replacing carbohydrate with soy or milk protein might be an important component of nutrition intervention strategies for the prevention and treatment of hypertension [25]. Dietary fiber, especially soluble fiber from oat bran, barley, beta-glucan and psyllium, is recommended for LDL-C lowering at a daily dose of 5-15 g/d [26,27]. This can also be used as foods enriched with these fibers.…”

Section: Diet Therapy and Behavioral Changesmentioning

confidence: 99%

Dietary strategy for prevention and management of dyslipidemia: international guidelines

Sucato

Sanfilippo

Triolo

et al. 2012

Mediterr J Nutr Metab

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Effect of Dietary Protein Supplementation on Blood Pressure

Cited by 84 publications

References 33 publications

Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial

Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Dietary strategy for prevention and management of dyslipidemia: international guidelines

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