Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Shiojima, Yoshiaki; Takahashi, Megumi; Takahashi, Ryohei; Moriyama, Hiroyoshi; Bagchi, Debasis; Bagchi, Manashi; Akanuma, Masanori

doi:10.1080/07315724.2021.1962770

Cited by 12 publications

(12 citation statements)

References 44 publications

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“…Likewise, Hwang et al [71] show daily supplementation with 20 mg PQQ optimizes mitochondrial biogenesis in human subjects. Notably, cognitive function and memory also are improved in human subjects, following PQQ supplementation (10-20 mg per day) [72][73][74].…”

Section: Humansmentioning

confidence: 99%

Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

2021

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Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and lipotoxicity). PQQ is novel among biofactors that are not currently accepted as vitamins or conditional vitamins. For example, the absence of PQQ in diets produces a response like a vitamin–related deficiency with recovery upon PQQ repletion in a dose-dependent manner. Moreover, potential health benefits, such as improved metabolic flexibility and immuno-and neuroprotection, are associated with PQQ supplementation. Here, we address PQQ’s role as an enzymatic cofactor or accessory factor and highlight mechanisms underlying PQQ’s actions. We review both large scale and targeted datasets demonstrating that a neonatal or perinatal PQQ deficiency reduces mitochondria content and mitochondrial-related gene expression. Data are reviewed that suggest PQQ’s modulation of lactate acid and perhaps other dehydrogenases enhance NAD+–dependent sirtuin activity, along with the sirtuin targets, such as PGC-1α, NRF-1, NRF-2 and TFAM; thus, mediating mitochondrial functions. Taken together, current observations suggest vitamin-like PQQ has strong potential as a potent therapeutic nutraceutical.

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Section: Humansmentioning

confidence: 99%

Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

2021

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“…Supplementation of selected functional foods and nutraceuticals, including glucosamine hydrochloride, Nacetylglucosamine, undenatured type II collagen, hyaluronic acid, and turmeric extract have shown to be efficacious in attenuating joint pain, discomfort and enhancing mobility. These ingredients are sufficiently safe and exert potential benefits against joint discomfort and improving locomotive functions such as walking, sitting, standing, and climbing the stairs [1][2][3][4][5][6][7].…”

mentioning

confidence: 99%

“…Among the functional food ingredients for joint health, undenatured type II collagen has been widely used for its proven beneficial effects on joint pain/discomfort and improving locomotive functions for many years [2][3][4][5][6]. Moreover, the ingredient is adequately safe with its common food origin and history of food use in the marketplace worldwide including Japan.…”

mentioning

confidence: 99%

“…It has also been demonstrated that undenatured type II collagen is highly safe for intake as evidenced by broad safety studies in animal models [7,8]. Multiple clinical studies have demonstrated their beneficial effects and efficacy in knee joint discomfort/pain and locomotive functions [3][4][5][6].…”

mentioning

confidence: 99%

“…Our recent randomized clinical trial (RCT) demonstrated that undenatured type II collagen derived from chicken sternum cartilage (NEXT-II ® ) significantly improved a wide array of discomfort/joint pain and difficulties in locomotive functions in human volunteers [6]. Most importantly, intake of a small amount of NEXT-II ® demonstrated to ameliorate knee joint discomfort and pain, while improving motor functions including flexibility and mobility.…”

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confidence: 99%

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Safety of Dietary Undenatured Type II Collagen: A Pilot Open-Label Overdose Clinical Investigation

Shiojima¹,

Takahashi²,

Takahashi³

et al. 2022

FFHD

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Background: In advancing age population worldwide, joint discomfort and poor locomotive functions are symptoms, which are often detected. Aggravation of such symptoms potentially develops into osteoarthritis (OA) as characterized by the loss of articular cartilage in the joints of the hand, spine, knee, foot, and hip. For joint health complications, selected functional foods are frequently supplemented orally to alleviate such symptoms. In Japan, Foods with Function Claims (FFC) regulatory system is now positioned within the framework of “so-called health foods” allowing to make functional claims such as brain health and weight control claims. Moreover, a wide variety of knee joint care FFC products are presently available in the marketplace and have attracted much attention of the elderly people, expecting improvements in joint locomotive functions such as walking, sitting, standing, and climbing the stairs for the quality of life (QOL). Supplementation of undenatured type II collagen powder (NEXT-II®) in hard capsules has been clinically proven to improve such joint functions fulfilling part of the FFC rigorous guidelines, while ensuring adequate safety as foods is a crucial prerequisite for filing FFC product dossier.Methods: Twenty-two healthy male and female volunteers (age = 20-74 years) participated in this pilot open-label overdose clinical trial over a period of 4 consecutive weeks. All subjects were also monitored and assessed additional 2 weeks after the completion of the NEXT-II® supplementation period as washout or supplement-free period. Subjects took a 10-fold (10-X) dose of NEXT-II® (400 mg NEXT-II/day containing 32 mg of undenatured type II collagen/day). Daily recommended dose of NEXT-II® is 40 mg/day (containing 3.2 mg of undenatured type II collagen/day) after breakfast. Physical health examination, hematological analysis, blood ,biochemistry examination, and urinalysis were performed. All subjects completed the supplementation of NEXT-II® for 4 weeks and had additional 2 weeks of washout or supplement-free period. All subjects recorded daily diaries. Results: Results demonstrated no significant differences at 0 week (baseline), 2 weeks, and 4 weeks of NEXT-II®supplementation. Furthermore, no significant differences were observed even after 2 weeks of the washout period. No adverse events were observed.Conclusions: Supplementation of 10-fold dose of NEXT-II® to the volunteers was well-tolerated and exhibited the broad-spectrum safety without observing any adverse effects in healthy Japanese subjects.Keywords: Undenatured type II collagen, NEXT-II®, Safety, Overdose supplementation, Clinical study, Foods with Function Claims (FFC)

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Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits

Yan,

Nisar,

et al. 2024

Current Research in Food Science

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Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Cited by 12 publications

References 44 publications

Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

Safety of Dietary Undenatured Type II Collagen: A Pilot Open-Label Overdose Clinical Investigation

Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits

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