Effect of Dietary Roxarsone Level on Leg Condition of Male Broilers

Waldroup, P. W.; Watkins, S. E.; Saleh, E. A.; Kessler, J. W.; Roney, C. Stephen; Skinner, J. T.

doi:10.1093/japr/4.2.186

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…Inclusion, however, produced an improvement in productivity and resistance to disease when Eimeria tenella or E. brunetti infection occurred (McDougald et al, 1992). Although roxarsone has been banned from dietary use in the UK and the European Union for some 10 years it is still widely used and combined with ionophores, anticoccidials or antibiotics in broiler rations in the US (Waldroup et al, 1995) and other parts of the world.…”

Section: Introductionmentioning

confidence: 99%

Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck

Chen

Chiou

2000

British Poultry Science

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1. The aim of this study was to examine the effects of roxarsone (3-nitro-4-hydroxyphenylarsonic acid) inclusion in the diet on the performance, liver function and lipid metabolism in the liver of laying Brown Tsaiya ducks. 2. Sixty 36-week-old laying ducks were selected and allocated at random into 4 dietary treatments with 3 replications for each treatment. Feeding was for 7 weeks with 3 weeks of experimental diets followed by a 4 week withdrawal period. The experimental diets were supplemented with 0, 50, 100 and 300 mg/kg roxarsone, respectively 3. Dietary inclusion of 50 or 100 mg/kg roxarsone did not significantly promote performance. Inclusion of 300 mg/kg significantly depressed (P<0.05) performance, liver weight and content, serum triacylglycerol (TG), serum nonesterified fatty acid (NEFA) and increased (P<0.05) cholesterol, creatine kinase (CK) and aspartate aminotransferase (AST) in the serum at the end of 3 weeks on the experimental diet. 4. Laying characteristics returned to normal 4 weeks after withdrawal of roxarsone. The liver weight, fat and TG in the liver and serum concentrations of TG, NEFA, high density lipoprotein (HDL) and AST increased significantly (P<0.05), while the level of very low density lipoprotein (VLDL) decreased (P<0.05) at the end of the withdrawal period. More prominent vacuolised hepatic fatty cells were observed in laying ducks treated with 300 mg/kg of roxarsone.

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Section: Introductionmentioning

confidence: 99%

Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck

Chen

Chiou

2000

British Poultry Science

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“…Arsenic in high dose generally decreases animal performance and causes abnormalities in the skin and hair (McDowell, 1992). However, organic arsenicals i.e., Roxarsone (3-nitro-4hydroxyphenylarsonic acid) and arsanilic acid, has been used as feed additive in poultry industries to improve production and control coccidiosis for decades (McDougald et al, 1992;Waldroup et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Arsenical Inclusion on Lipid Metabolism and Liver Function in Mule Ducks

Chen¹,

Chiou²

2006

Asian Australas. J. Anim. Sci

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This study evaluated the effectiveness of different arsenical sources on inducing fatty liver, on changes in lipid metabolism and on liver function in mule ducks. Sixty twelve-week-old mule ducks were selected and randomly divided into five treatments, including the control group and four different arsenical sources; Roxarsone (300 mg/kg), arsanilic acid, As 2 O 5 or As 2 O 3 , containing 85.2 mg/kg arsenic were included in the basal diet. The ducks were fed the medicated basal diet for 3 weeks followed by a one-week drug withdrawal. The results showed Roxarsone treatment decreased body weight, feed intake, liver weight and abdominal fat weight (p<0.05), while it increased the relative liver weight (p<0.05) during medication period (3 rd week). The As 2 O 5 treatment decreased abdominal fat weight and relative abdominal fat weight when compared to the control (p<0.05). Only Roxarsone among the treatment groups increased feed intake, liver weight and relative liver weight, while the As 2 O 3 group showed the lightest liver weight and relative liver weight among treatment groups during the withdrawal period (4 th week). The Roxarsone group decreased (p<0.05) NADP-malic dehydrogenase (MDH) and acetyl-CoA carboxylase (ACC) activities and increased (p<0.05) cholesterol concentration during the medication period, and elevated the MDH and ACC activities during the withdrawal period. All four arsenical treatment groups showed lymphocytic infiltration in liver tissue, while the Roxarsone and As 2 O 3 treatments showed an increase in aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities (p<0.05). During the withdrawal period, arsenical treatments resulted in liver vacuoles. However, the arsenicals differed in effectiveness and mechanisms of inducing fat vacuoles.

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Anticoccidial Drugs and Vaccines

Conway¹,

McKenzie²

2007

Poultry Coccidiosis

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Effect of Dietary Roxarsone Level on Leg Condition of Male Broilers

Cited by 8 publications

References 13 publications

Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck

Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck

Effects of Dietary Arsenical Inclusion on Lipid Metabolism and Liver Function in Mule Ducks

Anticoccidial Drugs and Vaccines

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