Effect of Dietary Selenium Supplementation on the Plasma Progesterone Concentration in Cows.

Kamada, Hiroki; Hodate, Koichi

doi:10.1292/jvms.60.133

Cited by 19 publications

(16 citation statements)

References 28 publications

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“…The parameters' weights of the second PLS component indicate the interrelationship between Se, P 4 , AoM, and ThV. The positive correlation between Se and P 4 is in accordance with experiments conducted both in vitro and in animal models, and this showed that selenium (probably as a component of GPX) degrades the peroxides produced in the corpus luteum and supports its production of progesterone [26]. On the other hand, the negative correlation between Se and ThV corresponds well with results reported recently by Derumeaux et al [27], who found the statistically highly significant inverse associations between SeS and ThV, risk of goiter, and hypoechogenicity in women (but not in men), in a study conducted on a large population with mild iodine deficiency.…”

Section: Discussionsupporting

confidence: 80%

The Interaction Between Selenium Status, Sex Hormones, and Thyroid Metabolism in Adolescent Girls in the Luteal Phase of their Menstrual Cycle

Zagrodzki¹,

Ratajczak²,

Wietecha‐Posłuszny³

2007

Biol Trace Elem Res

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The objective of the present work was to study all physiological relationships among selenium status (SeS), sex hormones secretion (SH), and thyroid metabolism (ThM) in healthy adolescent girls, at one time. Forty-four girls aged 13.4-16.6 years (mean age, 14.5 +/- 0.5 years) entered the statistical model. Parameters reflecting SeS: plasma selenium concentration (Se) and plasma glutathione peroxidase activity (GPX3); SH: serum estradiol (E2) and progesterone (P4); age of menarche (AoM); and ThM: thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), antithyroid peroxidase antibodies (anti-TPO) in serum, and thyroid volume (ThV), were determined, and the interactions between them were evaluated by means of the partial least squares method (PLS). PLS method was, for the first time, successfully applied to the problem of selenium and hormone interactions and revealed that selenium status and female reproductive system are interrelated and affect thyroid physiology in adolescent girls in the luteal phase. The strongest associations were revealed for the pairs of parameters, Se and fT4/fT3, Se and P4, the modest ones for the pairs, Se and ThV, P4 and fT4/fT3, Se and AoM, and P4 and AoM. There was no correlation between E2, GPX3, and TSH, and any other considered parameter. Se and P4 had the greatest influence on ThM parameters.

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Section: Discussionsupporting

confidence: 80%

The Interaction Between Selenium Status, Sex Hormones, and Thyroid Metabolism in Adolescent Girls in the Luteal Phase of their Menstrual Cycle

Zagrodzki¹,

Ratajczak²,

Wietecha‐Posłuszny³

2007

Biol Trace Elem Res

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“…From this information, we hypothesized that Se degrades peroxides in CL, which contributes to maintaining their function. We have reported that the addition of Se to cultured bovine luteal cells increased the P4 concentration of the culture medium [26] and that the Se supplementation of non-pregnant and non-lactating cows increased their plasma P4 concentration during the estrous cycle [27]. In the present study, it was clearly demonstrated that pre- and postpartum Se supplementation to the diet increased the postpartum plasma P4 concentration of dams.…”

Section: Discussionsupporting

confidence: 66%

Effects of selenium-rich yeast supplementation on the plasma progesterone levels of postpartum dairy cows

Kamada¹

2016

Asian-Australas J Anim Sci

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ObjectiveThe effects of the pre- and postpartum supplementation of cows with Se on their plasma P4 concentrations after calving were investigated.MethodsThirty-four Holstein cows were used to investigate the effects of dietary selenium supplementation on the postpartum recovery of the luteal function in cows. Selenium-rich yeast (containing 300 ppm selenium) was mixed with total mixed ration fed to 17 pregnant cows from 30 days before they were due to calve (10 g yeast daily) to 100 days after calving (20 g yeast daily). The control cows (n = 17) were fed the same amount of ordinary yeast. The cows’ plasma progesterone concentrations were determined every two days using an enzyme immunoassay after calving.ResultsFeed intake (total digestive nutrient, crude protein), milk production, body weight and the biochemical properties of blood plasma did not differ between the two groups; however, the plasma selenium concentrations of the supplemented animals were significantly greater than those of the controls at and after calving. The postpartum plasma progesterone concentrations of the selenium-yeast-supplemented group increased earlier than those of the control group. Moreover, during the estrus cycle after the 3rd ovulation or ovulation with estrus between 60 to 80 days after calving, the selenium-supplemented cows exhibited greater progesterone concentrations than the control cows.ConclusionSelenium supplementation promotes the postpartum progesterone production of cows.

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“…Furthermore, FSH receptor expression and biosynthetic pathway of estradiol were predominantly influenced by selenium (Basini & Tamanini, 2000). Selenium can also stimulate luteal cell proliferation and decrease toxic lipid peroxides, and consequently elevate progesterone level affecting luteal cells (Kamada & Hodate, 1998;Kamada & Ikumo, 1997). Therefore, it can be concluded that the observed maintenance of estrous cyclicity in PCO rats, after treatment by ANGIPARSÔ, was mainly due to restoring steroid status and enabling ovaries to function normally.…”

Section: Discussionmentioning

confidence: 96%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

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Submit your article to this journal Results: PCO rats exhibited ovarian cystogenesis which was preserved by the application of carvedilol and ANGIPARSä. In comparison with controls, decreased level of the total antioxidant power (TAP) and higher levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in serum and ovaries (2.41 ± 0.67 versus 0.72 ± 0.11; and 0.17 ± 0.04 versus 0.05 ± 0.01; 5.48 ± 1.30 versus 10.56 ± 0.77; and 7.06 ± 1.94 versus 17.98 ± 0.98; p50.05, respectively) were detected in PCO rats. Moreover, the PCO rats exhibited hyperandrogenism due to a 3.7-fold increase in serum testosterone concentration (35.04 ± 3.17 versus 131.09 ± 13.24; p50.05) along with a 2.98-fold decrease in serum progesterone (6.19 ± 0.40 versus 18.50 ± 1.03; p50.05) and 5.2-fold decrease in serum estradiol (9.30 ± 0.61 versus 48.3 ± 2.10; p50.05) when compared with those of the control group. However, similar to the control group, normal levels of OS markers and sex hormones were detected in ANGIPARSä and carvedilol co-treated PCO rats. Besides, when compared with controls, increased levels of TNF-a (770.75 ± 42.06 versus 477.14 ± 28.77; p50.05) and insulin (1.27 ± 0.10 versus 0.36 ± 0.05; p50.05) in PCO rats were significantly inhibited by carvedilol and ANGIPARSä co-treatment. Discussion and conclusion: We evidenced the beneficial effects of carvedilol and ANGIPARSä in PCO, which underpin the new alternative approach in using these kinds of medicines in female reproductive disorders.

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Effect of Dietary Selenium Supplementation on the Plasma Progesterone Concentration in Cows.

Cited by 19 publications

References 28 publications

The Interaction Between Selenium Status, Sex Hormones, and Thyroid Metabolism in Adolescent Girls in the Luteal Phase of their Menstrual Cycle

The Interaction Between Selenium Status, Sex Hormones, and Thyroid Metabolism in Adolescent Girls in the Luteal Phase of their Menstrual Cycle

Effects of selenium-rich yeast supplementation on the plasma progesterone levels of postpartum dairy cows

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

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