Effect of dietary supplementation of dates in Alzheimer's disease APPsw/2576 transgenic mice on oxidative stress and antioxidant status

Abstract

Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Changes in the oxidative stress, antioxidants, and membrane-bound enzymes were investigated in the cerebral cortex and hippocampus of AD transgenic mice model after long-term dietary supplementation of date palm fruits from Oman. The 4-month-old mice with double Swedish APP mutation (APPsw/Tg2576) were purchased from Taconic Farm, NY, USA; mice were fed two different doses of dates (such as 4 and 2%) or control diet for 15 months and then assessed for the influence of diet on oxidative stress. Significant increase in oxidative stress in terms of enhanced levels of lipid peroxidation (LPO) and protein carbonyls and parallel decrease in the activity of antioxidant enzymes were observed in control diet-treated Tg2576 AD mice. Dates (4 and 2%) treated APPsw/Tg2576 AD mice exhibited significantly attenuated oxidative damage, evidenced by decreased LPO and protein carbonyl levels and restoration in the activities of the antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione, and glutathione reductase). The activities of membrane-bound enzymes (Na(+), K(+)-ATPase and acetyl cholinesterase) were altered in control diet-treated APPsw/Tg2576 AD mice brain regions. Meanwhile, both the percentages of date supplementation were able to restore the activity of enzymes to comparable values observed in controls. In summary, we have shown that chronic dietary supplementation of date palm fruits grown in Oman showed possible beneficial effects concomitant with oxidative stress reduction and increased antioxidant enzymes in AD transgenic mice model. These results warrant further exploration of how anti-reactive oxygen species properties of dates offer such beneficial effects on the AD-like brain.

Pomegranate from Oman Alleviates the Brain Oxidative Damage in Transgenic Mouse Model of Alzheimer’s Disease

“…We recently reported that chronic dietary term supplementation of fruits could be beneficial for behavior and oxidative stress related changes in AD transgenic mice[59606162] which also support our present findings.…”

Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome

“…These mice also 419 display defects in the hippocampal long-term potentiation and cerebel-420 lar motor function (Huang et al, 2013;Gabriel et al, 1999). Cattanach among others (De Felice et al, 2014;Hayashi et al, 2012;Kaur et al, 462 2014;Subash et al, 2014a;Subash et al, 2014b;Valenti et al, 2014). …”

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

“…Hartman et al [61] pointed out that the antioxidant polyphenolic substances of pomegranate juice reduced amyloid load and improved behavior in an AD mouse. Subash et al [62] suggested that dietary supplementation of dates and figs improved cognitive and behavioral deficit via maintaining oxidant-antioxidant balances in APPsw/Tg 2576 transgenic AD mice. Nakajima et al [63] suggested that nobiletin significantly reduced oxidative stress and improved the cognitive impairment in a 3XTg-AD mouse model.…”

“…Hanish Singh et al [67] reported that ethanolic extract of Alpinia galangal improved the antioxidant status and inhibited the acetylcholine esterase activity in AD mice. Our research group from Oman reported the beneficial effects of natural products including pomegranate and figs on AD transgenic mice models [62, 68–77]. …”