Effect of dietary supplementation with vitamin A on arterial healing in rats

Niu, Xing T.; Cushin, Brian; Reisner, Andrew; Levenson, Stanley Μ.; Demetriou, Achilles A.

doi:10.1016/0022-4804(87)90066-7

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Impairment of the inflammatory response, tensile strength, and collagen accumulation in cutaneous wounds after steroid treatment are partially, but significantly, reversed by retinoid administration . Similar observations have been made when studying flexor tendon repair, healing of rat femoral fractures, vessel repair, and healing of intestinal anastomoses . Although steroid use and subsequent delay of healing is a well‐recognized clinical problem, the mechanisms of steroid retardation or reversal by retinoids are still incompletely understood.…”

Section: Vitamin a And Wound Healingsupporting

confidence: 53%

“…60,61 Similar observations have been made when studying flexor tendon repair, healing of rat femoral fractures, vessel repair, and healing of intestinal anastomoses. 31,[62][63][64][65] Although steroid use and subsequent delay of healing is a well-recognized clinical problem, the mechanisms of steroid retardation or reversal by retinoids are still incompletely understood. Glucocorticoid treatment results in decreased levels of transforming growth factor beta (TGF-β) and insulin like growth factor 1 (IGF-I) as well as reduced hydroxyproline content in granulation tissue, which are all at least partially reversed with oral all-trans-retinoic acid and 9-cis-retinoic acid.…”

Section: Vitamin a And Wound Healingmentioning

confidence: 99%

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The Role of Vitamin A in Wound Healing

2019

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Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro–vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol‐binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator‐activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re‐epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti‐inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.

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Section: Vitamin a And Wound Healingsupporting

confidence: 53%

Section: Vitamin a And Wound Healingmentioning

confidence: 99%

The Role of Vitamin A in Wound Healing

2019

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“…Impairment of the inflammatory response, tensile strength, and collagen accumulation in cutaneous wounds after steroid treatment are partially, but significantly, reversed by retinoid administration (retinyl ester, retinol, and/or retinoic acid). 2 Similar observations were made studying flexor tendon repair, 3 healing of rat femoral frac-tures, 4 vessel repair, 5 and healing of intestinal anastomoses. 6 Although steroid retardation of healing is a significant clinical problem and a commonly used laboratory model in the study of repair processes, little is known about the mechanisms of either steroid retardation or reversal by retinoids.…”

mentioning

confidence: 58%

Effects of Steroids and Retinoids on Wound Healing

Wicke

Halliday²,

Allen³

et al. 2000

Archives of Surgery

300

177

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Anti-inflammatory corticosteroids significantly impair wound healing. Retinoids partially, but significantly, reverse this effect. Little is known about the mechanism of steroid retardation or retinoid reversal. We hypothesized that corticosteroids lower transforming growth factor-␤ (TGF-␤) and insulinlike growth factor-I (IGF-I) levels and tissue deposition in wounds and that retinoids stimulate corticosteroid-impaired TGF-␤ and IGF-I release and collagen production.

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Nutrition, Metabolism, and Wound Healing in the Elderly

Jacobs¹,

Lara²

2001

Principles and Practice of Geriatric Surgery

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Effect of dietary supplementation with vitamin A on arterial healing in rats

Cited by 8 publications

References 8 publications

The Role of Vitamin A in Wound Healing

The Role of Vitamin A in Wound Healing

Effects of Steroids and Retinoids on Wound Healing

Nutrition, Metabolism, and Wound Healing in the Elderly

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