Effect of Dietary Supplementation with Very-Long-Chain n-3 Fatty Acids in Patients with Psoriasis

Søyland, Elisabeth; Funk, Jürgen; Rajka, G; Sandberg, Morten; Thune, P; Rustad, Lisbeth; Helland, Ståle J.; Middelfart, Kjell; Odu, Solveig; Falk, Edvard S.; Solvoll, Kari; Bjørneboe, Gunn‐Elin Aa.; Drevon, Christian A.

doi:10.1056/nejm199306243282504

Cited by 117 publications

(95 citation statements)

References 30 publications

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“…Soyland et al [19] conducted a 4-month, double-blind, randomized, placebo-controlled, multicenter trial among 145 patients with moderate-to-severe plaque psoriasis. The patients were randomly assigned to either the fish-oil group, in which each patient received six capsules daily (each capsule had 1 g of omega-3 fatty acids(51% EPA, 32% DHA) or to the control group in which each patient received six capsules of corn oil daily (each capsule containing 1 g of omega-6 fatty acids (26% oleic acid, 56% linoleic acid); the score of the Psoriasis Area and Severity Index (PASI) levels did not change significantly in either group at the end of the trial.…”

Section: Fish Oil and Psoriasismentioning

confidence: 99%

n-3 polyunsaturated fatty acids supplementation in psoriasis: a review

Mari

Simão

Dichi

2017

Nutrire

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Psoriasis is an immune mediated chronic inflammatory disease of unknown etiology and characterized by epidermal hyperplasia and inappropriate immune activation, which affects the skin and joints as well.The immunopathogenesis of psoriasis involves changes in the innate and acquired (T lymphocytes) immune system. The cells of the innate immune system when activated produce growth factors, cytokines, and chemokines that act on cells of the acquired immune system and vice versa, being characterized as atype 1 immune response disease. Fish oil n-3 polyunsaturated fatty acids, mainly eicosapentaenoic (EPA), and docosahexaenoic acids (DHA), reduce symptoms in many inflammatory skin diseases. The mechanism of action of fish oil in the treatment of psoriasis is widely based on the alteration of epidermal and blood cell membrane lipid composition. In the present study, we performed a review of the several studies, which analyzed the action of n-3 polyunsaturated fatty acids in patients with psoriasis. Taken together, the majority of the studies showed that n-3 polyunsaturated fatty acids, mainly from marine origin, have beneficial effects and can be utilized as adjuvant therapy in psoriasis treatment. Both oral and intravenous administration of fish oil n-3 polyunsaturated fatty acids had positive effects. However, further studies are warranted to answer many intriguing questions, for instance, the ideal quantity of fish oil to be utilized, the effect on different forms and severity of psoriasis and last, but not least, the consequences of using fish oil n-3 polyunsaturated fatty acids on the cardiovascular features of patients with psoriasis.

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Section: Fish Oil and Psoriasismentioning

confidence: 99%

n-3 polyunsaturated fatty acids supplementation in psoriasis: a review

Mari

Simão

Dichi

2017

Nutrire

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“…LTB4 was found to have significantly decreased in the treatment group (P < 0.03) but not in the control group. The other six studies 5,6,14,15,17,18 reported no significant reduction in scaling, erythema, area involved or thickness. Gupta et al 5 reported the mean time period elapsed before the psoriasis worsened to pre-therapy severity was 4.9 AE 0.5 weeks in the intervention group and 4.5 AE 0.6 weeks in the control group (P = 0.4).…”

Section: Description Of Included Studiesmentioning

confidence: 91%

“…They also reported a significant rise in serum concentration of EPA and fall in the ratio of AA to EPA and n-3 to n-6 PUFA after treatment (P < 0.01). 15 Soyland et al 17 reported a significant decrease in the infiltration and scaling scores (P < 0.01) in the intervention group, but also a significant decrease from baseline in the scores for desquamation (P < 0.05), redness (P < 0.05) and scaling (P < 0.01) in the control group; however, there were no significant differences between the two groups. Interestingly, Soyland's study also found that the concentration of EPA increased 3.6-fold, whereas DHA increased by 39% in serum phospholipids in subjects who received n-3 PUFA.…”

Section: Description Of Included Studiesmentioning

confidence: 93%

“…A total of 720 articles were excluded because they were not randomized controlled trials or observational studies (427 articles), did not involve dietary or pharmacologic interventions with n-3 fatty acids (210 articles), did not perform a comparison (65 articles), or did not include the outcome of interest (18 articles). Eleven randomized controlled trials [4][5][6][11][12][13][14][15][16][17][18] and one open-label controlled observational study 19 were included, and the data of all 12 studies were extracted. The characteristics of the extracted studies are outlined in Table 1.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

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Effect of omega‐3 fatty acids on disease severity in patients with psoriasis: A systematic review

et al. 2017

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Aim: Many randomized controlled trials have been performed on the efficacy and mechanism of action of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on psoriasis. However, contradictory results have been obtained. This study wants to assess the effects of n-3 PUFAs on the severity of psoriasis. Methods:The Cochrane Central Register of Controlled Trials, PubMed/MEDLINE and EMBASE were searched for all randomized controlled trials and prospective observational studies comparing the efficacy of n-3 PUFAs versus control in adult patients with psoriasis. The primary outcome was psoriasis severity as measured by the Psoriasis Area Severity Index (PASI) score. Results:The initial search yielded 732 articles, 720 of which were excluded. The data of the 12 remaining studies were extracted. Some studies found that n-3 PUFAs were associated with improvements in the PASI score, erythema, scaling, itching, area involved and infiltration. However, some studies did not find reduction in scaling, erythema, area involved or thickness in the treatment group. Conclusion:It is still inconclusive whether use of n-3 PUFAs in patients with psoriasis is associated with improvements in severity of psoriasis and other outcomes.

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confidence: 99%

Effects of arachidonic and eicosapentaenoic acid derived eicosanoids on polymorphonuclear transmigration

Moreno

2010

Proc. Nutr. Soc.

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The n-3 polyunsaturated fatty acids contained in fish oil provide it with anti-inflammatory effects on different inflammatory diseases (1,2) . Several mechanisms can be involved in the influence of the degree of unsaturation of dietary fatty acids on the development of inflammatory diseases (3) . The beneficial effects of fish oil on inflammatory diseases have been attributed to the EPA/docosahexaenoic acid (DHA) content. EPA is also substrate for AA cascade enzymes, but induced the production of alternative eicosanoids such as 3-serie prostanoids and 5-serie leukotrienes that are considered to be less pro-inflammatory compared with AA metabolites. Thus, fish oil diet reduced AA mobilization and the subsequent prostaglandin (PG)E 2 synthesis (4) . However, the molecular basis of beneficial effect of EPA supplementation is poorly understood as well as the comparative biological effects of AA and EPA metabolites.Leucocyte recruitment to inflamed areas is a pivotal event in the development of the inflammatory processes (5) . In this work, we studied the effects of PGE 2 and PGE 3 on endothelium permeability, the effects of leukotriene B 4 (LTB 4 ) and LTB 5 on endothelium permeability as well as mononuclear adhesion and migration.Endothelial monolayer permeability to albumin was measured in ECV304 cell cultures using the Casnocha et al. methodology (6) . Polymorphonuclear (PMN) granulocytes were isolated from human blood samples using Histopaque-1077. ECV304 cell confluent cultures were plated with PMN in the presence of eicosanoids and allowed to attach at 37 C for 3 h. Non-adherent cells were removed, cultures were fixed and PMN adhered to ECV304 monolayer were counted under a phase-contrast microscope. LFA-1 and MAC-1, and E-selectin and ICAM-1 expression on PMN and ECV304 surface, respectively, were analysed with a fluorescein-activated cell sorter analyser using the corresponding antibodies to each adhesion molecule. PMN chemotaxis was measured using the modified Boyden chamber technique (7) and a locomotion index was calculated using Maderazo and Woronick method (8) . Results are means°SE of three independent experiments performed in duplicate. Student's t test was used to determine the significance.Our results show that both prostaglandins (PGE 2 and PGE 3 , 0.1-100 nM) increased trans-endothelial Evans blue-albumin (EBA) permeability in a concentration-dependent manner, reaching a maximum plateau effect at 100 nM. Interestingly, the effect of PGE 3 (increased 115°3% v. control) (P < 0.001) was slight higher than PGE 2 (90°4%) (P < 0.001) action and both were significantly antagonised by EP 1 (SC19200, 1 mM) and EP 2 (AH6809, 1 mM) antagonist, but not by EP 3 and EP 4 antagonist. LTB 4 and LTB 5 presented a slight effect on EBA extravasation (32°2 % and 21°1.5%, respectively. LTB 4 (1-100 nM) caused significant increases in the number of PMN cell adhering to endothelial cells (280°13 %-405°21 %) (P < 0.001 in all concentrations), whereas LTB 5 was not able to induce an appreciable effect. This effect of LTB ...

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Effect of Dietary Supplementation with Very-Long-Chain n-3 Fatty Acids in Patients with Psoriasis

Cited by 117 publications

References 30 publications

n-3 polyunsaturated fatty acids supplementation in psoriasis: a review

n-3 polyunsaturated fatty acids supplementation in psoriasis: a review

Effect of omega‐3 fatty acids on disease severity in patients with psoriasis: A systematic review

Effects of arachidonic and eicosapentaenoic acid derived eicosanoids on polymorphonuclear transmigration

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