Effect of dietary turmeric (curcuma longa) on iron-induced lipid peroxidation in the rat liver

Reddy, Amala; Lokesh, Belur R.

doi:10.1016/0278-6915(94)90201-1

Cited by 201 publications

(33 citation statements)

References 18 publications

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“…The literature indicates a great variety of pharmacological activities of turmeric or curcumin, such as antibacterial, antiparasitic, anti-HIV (human immunodeficiency virus effects) (Mesa et al, 2000;Mazumber et al, 1995). It appears to have a good potential as a wound healing powder when applied externally to septic and aseptic wounds (Phan et al, 2001), due to proven anticarcinogenic (Ozaki et al, 2000;Aruna and Sivaramakrishnan, 1996;Huang et al, 1991Huang et al, , 1988, antioxidant and inhibition of lipid peroxidation (Phan et al, 2001;Scartezzini and Speroni, 2000;Unnikrishnan and Rao, 1995;Pulla Reddy and Lokesh 1994;Sreejayan Rao, 1994) and antiinflammatory properties with few toxic effects (Rao et al, 1982). It is also used for prevention, treatment or control of psoriasis and other skin conditions such as acne, wounds, burns, eczema, sun damage to the skin and premature aging, due to inhibiting the activity of phosphorylase kinase (Heng, 1999).…”

Section: Eczemamentioning

confidence: 95%

Plants used in cosmetics

Aburjai

Natsheh

2003

Phytotherapy Research

470

293

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This review describes the use of some natural products in cosmetic preparations, due to their low mammalian toxicity, with a brief description of the major use, plant parts used, the actives responsible for effect and the benefits of such products. Their use in skin care; such as dryness, eczema, acne, free-radical scavenging, antiinflammatory, antiaging and skin protection effects are explained, and also the use in hair care as hair growth stimulants, hair colorants, and for hair and scalp complaints such as dandruff. Essential oils when incorporated into finished products impart many benefits such as a pleasant aroma in perfumery, shine or conditioning effects in hair care products, emolliency and improving the elasticity of the skin.

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Section: Eczemamentioning

confidence: 95%

Plants used in cosmetics

Aburjai

Natsheh

2003

Phytotherapy Research

470

293

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“…Curcumin is a good antioxidant and inhibits lipid peroxidation in rat liver microsomes, erythrocyte membranes and brain homogenates (Pulla Reddy & Lokesh 1994). The lipid peroxidation has a main role in the inflammation, in heart diseases, and in cancer.…”

Section: Chemistrymentioning

confidence: 99%

Biological activities of Curcuma longa L.

Araújo

Leon

2001

Mem. Inst. Oswaldo Cruz

640

369

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“…Besides these, curcumin regulates a wide array of cellular processes such as inhibition of NF-jB and AP1 transcription which consequently decreases the expression of pro-inflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase and lipooxygenase, which contribute to reduce the inflammation and radical oxidant synthesis [6]. Feeding turmeric to mice prevented tumor formation normally caused by benzopyrene, 3-methylcholanthrene, and 3 0 -methyl-4-(dimethylamino) benzene [7]. Turmeric inhibited mutagenicity of cigarette smoke condensates and tobacco extracts [8].…”

Section: Introductionmentioning

confidence: 99%

Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani

et al. 2008

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Curcumin, a polyphenol compound, has been recognized as a promising anti-cancer drug. The purpose of the present study was to investigate the cytotoxicity of curcumin to Leishmania donovani, the causative agent for visceral leishmaniasis. Flow cytometric analysis revealed that curcumin induced cell cycle arrest at G2/M phase. Incubation of Leishmania promastigotes with curcumin caused exposure of phosphatidylserine to the outer leaflet of plasma membrane. This event is preceded by curcumin-induced formation of reactive oxygen species (ROS) and elevation of cytosolic calcium through the release of calcium ions from intracellular stores as well as by influx of extracellular calcium. Elevation of cytosolic calcium is responsible for depolarization of mitochondrial membrane potential (DeltaPsim), release of Cytochrome c into the cytosol and concomitant nuclear alterations that included deoxynucleotidyltransferase-mediated dUTP end labeling (TUNEL) and DNA fragmentation. Taken together, these data indicate that curcumin has promising antileishmanial activity that is mediated by programmed cell death and, accordingly, merits further investigation as a therapeutic option for the treatment of leishmaniasis.

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Effect of dietary turmeric (curcuma longa) on iron-induced lipid peroxidation in the rat liver

Cited by 201 publications

References 18 publications

Plants used in cosmetics

Plants used in cosmetics

Biological activities of Curcuma longa L.

Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani

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