Effect of dietary vitamin B₆ contents on antibody production

Abstract

When mice were placed on diets extreme deficient in vitamin B6, ovalbumin-dependent antibody productions (IgE, IgG1, IgG2a) were significantly suppressed, and alanine aminotransferase activity in the liver was also significantly decreased. In the case of pyridoxine excess (6 mg% = about ten times standard amount) in a 70% casein diet, ovalbumin-dependent antibody productions were also considerably suppressed. These responses were weaker in a low casein (5%) or normal casein (20%) diet than in a 70% casein diet. The administration of high doses of pyridoxine (6 mg%) resulted in the suppression of hepatic cathepsin B activity. Therefore, we conclude that ovalbumin-dependent antibody productions (IgG1, IgE) were suppressed by pyridoxine excess diet (6 mg%), because hepatic cathepsin B activity was suppressed by the excess pyridoxine in diet.

Effects of dietary pyridoxine on immune responses in abalone, Haliotis discus hannai Ino

“…Ha et al [9] believed that high-dose PN (seven times the optimal requirement) in diets had no effect on immunocompetence in rats. However, Inubushi et al [12] pointed out that excess PN (10 times the optimal requirement) in diets was able to suppress antibody productions in rats.…”

“…Dietary deficiency of PN significantly decreases cell-mediated immunity, such as percentage and total number of lymphocytes, the mitogenic responses of lymphocytes in human [8], T-cell-mediated cytotoxicity in rats [9] and humor-mediated immunity, such as interleukin 2 secretion in human [8] and antibody (IgE, IgG) production in rats and chicks [10e12]. However, there is controversy about the effects of high-dose PN on immune responses in terrestrial animals [9,12,13]. Ha et al [9] believed that high-dose PN (seven times the optimal requirement) in diets had no effect on immunocompetence in rats.…”

Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations

“…Subsequently, vitamin B6 supplementation in the deficient groups resulted in the serum antibody (IgG) and anti-DNP IgE recovering to the same levels as those in the normal controls [15]. Further research showed that excessive vitamin B6 (6 mg/100 g diet) supplementation could inhibit the production of the anti-OVA antibody IgE and IgG1 due to the suppression of hepatic cathepsin B activity by vitamin B6 [16]. Therefore, a moderation of vitamin B6 might mediate immune signal transduction or regulate immune cell differentiation and cytokine production together with other signal molecules to reach an immune homeostasis.…”

Dietary protein deficiency in pregnant mice and offspring

“…No studies have demonstrated the effects of dietary protein deficiency on lymphocyte blastogenesis involving antigen-specific reactions such as those expected in ova-immunized pregnant mice. However, ovalbumin immunization of nonpregnant mice fed a pyridoxine supplemented diet decreases the production of several subgroups of antibodies (Inubushi et al, 2000) and a limitation on parity, correlated with high titers of autoantibodies amplified by alloantigens, has been demonstrated in ova-immunized mice (Lou et al, 1996).…”