Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver

Ishii, Takashi

doi:10.1017/s0007114514000841

Cited by 13 publications

(9 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in a research carried out in rats, ALA/DHLA were shown to increase the mRNA expression of proteins involved in the redox system. Consistent with this protective activity, a dose dependent decrease of malondialdehyde concentrations was detected [68].…”

Section: An Overview On Some Specific Effects Of Alasupporting

confidence: 64%

Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage

Monastra

Grazia

Mıçılı

et al. 2016

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Alpha lipoic acid (ALA) is an essential mitochondrial co-factor and, as a free molecule, it can exert multi-level immunomodulatory functions. Both ALA and its reduced form, dihydrolipoic acid (DHLA), are believed to be able to chelate heavy metals, to regenerate essential antioxidants and to repair important molecules damaged by oxidation. The largest part of the effects of ALA/DHLA couple can be explained by a specific stimulatory activity on Nrf2-dependent gene transcription and by the inhibition of NF-kB activity. These features have prompted its use as a drug for several diseases. Areas covered: This article surveys the main features of ALA/DHLA and its therapeutic effects. Its complex and differentiated function cannot simply be reduced to anti-inflammatory, antioxidant and detoxifying action. We highlight its capability to finely modulate several physiological pathways when unbalanced. In particular, we focus our attention on pregnancy, in relation to ALA administration by oral route and by a new formulation for vaginal delivery, in patients with threatened miscarriage. Expert opinion: Future efforts should be devoted to explaining carefully ALA/DHLA mechanism of action to reactivate the physiological balance when modified during pregnancy. On the other hand, ALA safety in pregnant women and its pharmacokinetics by vaginal route, have to be studied in depth. Moreover, ALA efficacy has to be confirmed in a much larger sample of patients.

show abstract

Section: An Overview On Some Specific Effects Of Alasupporting

confidence: 64%

Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage

Monastra

Grazia

Mıçılı

et al. 2016

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

show abstract

“…Besides, the mRNA expression of HdhMT was also significantly increased with elevated expression of HdhMTF‐1, which was found to be Cd inducible in H. discus hannai (Lee & Nam, ). Similarly, dietary LA significantly increased the mRNA expression of metallothioneins ( Mt1a and Mt2A ) in rat liver (Ide, ). It has also been found that mouse metallothioneins ( Mt1 and Mt2 ) are overwhelming in response to transcriptional regulation of MTF‐1 when exposed to Cd (Wimmer, Wang, Georgiev, & Schaffner, ).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of dietary α-lipoic acid on abalone Haliotis discus hannai against the oxidative damage under waterborne cadmium stress

Huang

Lei

et al. 2018

Aquacult Nutr

View full text Add to dashboard Cite

A 60‐day feeding trial was conducted to investigate the protective effects of dietary α‐lipoic acid (LA) on juvenile abalone Haliotis discus hannai against the oxidative damage under waterborne cadmium (Cd) stress. Three experimental diets were formulated with 0 (Control), 700 (LA‐700) and 2100 (LA‐2100) mg/kg supplement of LA respectively. Each diet was randomly assigned to three replicates of 50 abalones (initial body weight: 3.17 ± 0.01 g), which were exposed to 0.35 mg/L of waterborne Cd. Results showed that abalones’ Cd bioaccumulation in the serum, mantle, gill, muscle and hepatopancreas were significantly reduced in LA supplement groups. Besides, in hepatopancreas, the activities of antioxidative enzymes and concentration of glutathione (GSH) in LA supplement group were significantly higher than those in control. Meanwhile, in hepatopancreas, LA‐2100 group showed a significantly decreased malondialdehyde (MDA) concentration and the protein carbonyls in LA supplement groups were significantly lower than those in control. Diets with LA supplementation significantly upregulated the mRNA expression of HdhMTF‐1 (H. discus hannai metal‐responsive transcription factor‐1) and HdhMT (H. discus hannai metallothionein), and elevated metallothionein (MT) concentrations in hepatopancreas. In conclusion, it was suggested that dietary LA could alleviate Cd‐induced oxidative damage through enhancing antioxidative enzyme activities and upregulating the HdhMTF‐1‐mediated HdhMT transcription and synthesis.

show abstract

“…Several researchers reported that dietary PUFA downregulated the expression of lipogenic enzymes [7,8] and enzyme synthesis with a decrease in hepatic fatty acid synthesis [9,10] in the rat liver.…”

Section: Introductionmentioning

confidence: 99%

Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats

Ebrahimi

Rajion

Goh

et al. 2015

Electronic Journal of Biotechnology

View full text Add to dashboard Cite

Background: There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results: An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P b 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions: In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.

show abstract

Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver

Cited by 13 publications

References 69 publications

Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage

Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage

Protective effects of dietary α-lipoic acid on abalone Haliotis discus hannai against the oxidative damage under waterborne cadmium stress

Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats

Contact Info

Product

Resources

About