Effect of Diethylstilbœstrol on the Serum γ-Globulin in the Guinea Pig

Distinctive serum globulin responses to parenteral treatment with 17‐β‐estradiol in female NZB/NZW mice

“…Varga found increased levels of a-, p-and 7-globulins in rats treated with estrogen (16). Treatment of guinea pigs with diethylstilbestrol has been found to stimulate increased levels of serum 7-globulins (17). In our study, estradiol treatment stimulated increases of a2-globulins in Swiss Webster mice but 7-globulins were not increased in this strain.…”

“…This finding suggests that female hybrid mice that demonstrate early serologic markers of autoimmune disease are less responsive to the stimulating effects of estradiol on serum globulins. Studies by others (17)(18)(19) suggest that estrogen can either stimulate or s u p press immunologic phenomena in experimental animals. This may be related to the species of animal, the maturity of the animal and the dose and duration of treatment.…”

“…The target organ effects of this hormone are conditioned by a number of metabolic factors (16,17,19), even in the offspring of two inbred strains of mice. Undoubtedly, the mechanism responsible for the apparent provocative effect of estrogen in drug-induced and spontaneous autoimmune disorders in humans is equally complex (1-7).…”

Modulatory Effects of Oestrogen on Immunologic Responsiveness

“…Increased: A Cortiocosteroid-bindmg globulin; ß-glucuronidase and ceruloplasmin B 7-Globulin Musa et al (1965) Charles andNicol (1961) implications of such effects as related to the prostate, e.g., are clearly seen in the suppressive effects of oestrogen on the development of pros tatic antibodies following experimental cryosur gery of the prostate {Stoll Ablin et al, 1975a); in the suggested increased survival and superior clinical response to cryotherapy of pa tients who had not received hormonal therapy vs. patients who had received such therapy (O'Donoghue et al, 1975) and from most recent histological evidence suggesting that oestrogen suppresses a local immunologic response develop ing in the prostate following cryosurgery in pa tients not receiving oestrogen {Petersen et al, 1978).…”

Effects of various drugs on insulin antibodies

“…In this study insulin antibodies were produced in guinea-pigs, because of the ease with which this can be done (Morse, 1959). Glucocorticoids are beneficial in insulin resistance (Oakley, Field, Sowton, Rigby & Cunliffe, 1959); oestrogens have immunopotentiating action (Nicol & Ware, 1960;Charles & Nicol, 1961); and the literature on the immunosuppressive action of anticancer drugs is accumulating (Hitchings & Elion, 1963;Schwartz, 1965;Gabrielsen & Good, 1967;Cooper & Amiel, 1968). Therefore, the effect of hydrocortisone, sex steroids and anticancer agents on the insulin antibody titre of the serum in guinea-pigs was examined.…”