Effect of Diets with Mulberry Leaf and Cudrania tricuspidata Leaf Powder Supplements on Blood Glucose-Related Biomarkers in Streptozotocin-Induced Diabetic Rats

Park, Ju-Hun; Lee, Kyoung-Won; Sung, Ki-Seung; Kim, Sung Soo; Cho, Kyung-Dong; Lee, Bog‐Hieu; Han, Chan-Kyu

doi:10.3746/jkfn.2012.41.6.766

Cited by 14 publications

(7 citation statements)

References 14 publications

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“…Cudrania tricuspidata has traditionally been used as a medicinal plant for conditions including eczema, tuberculosis, and chronic back pain [ 1 ]. According to previous studies, the plant has many beneficial characteristics, including antioxidative [ 2 ], antimicrobial [ 3 ], antitumor [ 4 ], antiobesity [ 5 ], anti-osteoarthritis [ 6 ], antiaging [ 7 ], antiinflammatory, and neuroprotective [ 8 ] properties. It also shows efficacy against cardiovascular diseases [ 9 ] such as atherosclerosis and hypertension [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Jirisan Mountain Cudrania tricuspidata leaf substance extraction across solvents and temperatures

Kim

2018

J Pharmacopuncture

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Section: Introductionmentioning

confidence: 99%

Optimization of Jirisan Mountain Cudrania tricuspidata leaf substance extraction across solvents and temperatures

Kim

2018

J Pharmacopuncture

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“…One study reported that CT leaves inhibited lipase activity, reduced plasma triacylglycerol levels, and delayed lipid absorption in vivo ( 28 ). In addition, recent studies found that CT has anti-inflammation and antihyperglycemia effects ( 29 – 31 ). Although there is increasing evidence of various physiological activities by CT, the detailed molecular mechanisms for these activities have not yet been elucidated.…”

mentioning

confidence: 99%

Cudrania tricuspidatawater extract improved obesity-induced hepatic insulin resistance indb/dbmice by suppressing ER stress and inflammation

Kim

Nam

Jun

et al. 2015

Food & Nutrition Research

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BackgroundObesity can play a role in the development of hepatic insulin resistance. Although the molecular mechanism of the association between obesity and hepatic insulin resistance is unclear, it has been reported that obesity leads to hepatic endoplasmic reticulum (ER) stress and inflammation, which can induce the development of insulin resistance in several tissues.ObjectiveIn this study, we investigated the associations between hepatic insulin resistance, ER, and inflammation in obesity and the effect of water extract from Cudrania tricuspidata leaves (CTL) on hepatic insulin resistance induced by ER stress and inflammation in db/db mice.DesignThe mice were randomly divided into four groups: a normal control group (C57BL/6J), a control group (C57BL/6J-db/db), a CTL 100 group (C57BL/6J-db/db mice fed a dietary supplement of 100 mg/kg of CTL), and a CTL 300 group (C57BL/6J-db/db mice fed a dietary supplement of 300 mg/kg of CTL). After 8 weeks, we performed an oral glucose tolerance test and the mice were sacrificed.ResultsThe C57BL/6J-db/db mice developed obesity and hyperglycemia, and the ER stress response and inflammation were activated in their livers. Interestingly, there was a marked decrease in the activation of the ER stress response and insulin resistance in the livers of the C57BL/6J-db/db mice treated with CTL due to decreases in the phosphorylation of eIF2α, IRE1α, and IRS-1 serine and decreases in the mRNA expression of ATF4, c-Jun N-terminal kinase, C/EBPα, and C/EBP homologous protein. Dietary supplementation with CTL also induced a statistically significant decrease in the expression of pro-inflammatory cytokines, C-reactive protein (CRP), and NF-κB phosphorylation.ConclusionsOverall, these results suggest that CTL can improve hepatic insulin resistance and hyperglycemia by controlling obesity-induced ER stress and inflammation in the liver and that CTL may be a useful agent in treating hyperglycemia.

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“…Recent studies have revealed that Cudrania tricuspidata (CT) has antioxidant, anti-obesity, anti-inflammation and anti-hyperglycemic effects [ 16 , 17 , 18 , 19 , 20 ]. CT, of the family Moraceae, is mainly found in East Asia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells

2016

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In this study, we quantitated kaempferol in water extract from Cudrania tricuspidata leaves (CTL) and investigated its effects on endoplasmic reticulum (ER) stress-induced inflammation and insulin resistance in HepG2 cells. The concentration of kaempferol in the CTL was 5.07 ± 0.08 mg/g. The HepG2 cells were treated with 300 µg/mL of CTL, 500 µg/mL of CTL, 1.5 µg/mL of kaempferol or 2.5 µg/mL of kaempferol, followed immediately by stimulation with 100 nM of thapsigargin for ER stress induction for 24 h. There was a marked increase in the activation of the ER stress and inflammation response in the thapsigargin-stimulated control group. The CTL treatment interrupted the ER stress response and ER stress-induced inflammation. Kaempferol partially inhibited the ER stress response and inflammation. There was a significant increase in serine phosphorylation of insulin receptor substrate (IRS)-1 and the expression of C/EBPα and gluconeogenic genes in the thapsigargin-stimulated control group compared to the normal control. Both CTL and kaempferol suppressed serine phosphorylation of IRS-1, and the treatments did not interrupt the C/EBPα/gluconeogenic gene pathway. These results suggest that kaempferol might be the active compound of CTL and that it might protect against ER stress-induced inflammation and hyperglycemia.

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Effect of Diets with Mulberry Leaf and Cudrania tricuspidata Leaf Powder Supplements on Blood Glucose-Related Biomarkers in Streptozotocin-Induced Diabetic Rats

Cited by 14 publications

References 14 publications

Optimization of Jirisan Mountain Cudrania tricuspidata leaf substance extraction across solvents and temperatures

Optimization of Jirisan Mountain Cudrania tricuspidata leaf substance extraction across solvents and temperatures

Cudrania tricuspidatawater extract improved obesity-induced hepatic insulin resistance indb/dbmice by suppressing ER stress and inflammation

Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells

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