The influence of tillage and nitrogen fertilization methods on soil quality attributes and crop agronomic characteristics has been studied broadly under different agroclimatic conditions. Nevertheless, the interactive effect of tillage and fertilization approaches on soil properties on different soil depths and yield is rarely addressed, particularly on the Loess Plateau belt, and requires more exploration. Thus, this research was conducted in order to evaluate the interactive impact of tillage and nitrogen fertilization methods on soil properties and wheat productivity. The treatments included conventional tillage (CT) and no-till (NT) with different fertilization approaches (no fertilization: CK, chemical nitrogen fertilizer: N, organic fertilizer: M, combined application of nitrogen fertilizer and organic fertilizer: NM) and were explored in a split plot arrangement under a randomized complete block design replicated thrice on soil properties (SWC, SOC, TN, TP, NO3−-N, NH4+-N, and stoichiometric ratio) and wheat yield. The results showed that sole no-tillage and NT in association with nitrogen fertilization (inorganic and organic) significantly increased the soil water content, SOC, TN, NH4+-N, C/P, and N/P ratios and wheat productivity but did not significantly yield TP, whilst it reduced the NO3−-N and C/N ratio compared with sole CT and CT together with nitrogen fertilization (organic and inorganic). Overall, NT in association with the joint application of inorganic and organic N fertilization are the best techniques to improve soil water status and nutrient status under the wheat mono-cropping system conditions and yield.