2019
DOI: 10.1371/journal.pone.0219113
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Effect of different anaesthetic techniques on gene expression profiles in patients who underwent hip arthroplasty

Abstract: Objectives To investigate the modulation of genes whose expression level is indicative of stress and toxicity following exposure to three anaesthesia techniques, general anaesthesia (GA), regional anaesthesia (RA), or integrated anaesthesia (IA). Methods Patients scheduled for hip arthroplasty receiving GA, RA and IA were enrolled at Rizzoli Orthopaedic Institute of Bologna, Italy and the expression of genes involved in toxicology were evaluated in peripheral blood mono… Show more

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Cited by 4 publications
(5 citation statements)
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“…ORTHOTEP University HS Carl Gustav Carus [ 109 , 619 ] 2. Dresden Hip Surgery Registry [ 52 , 196 ] Heidelberg University of Heidelberg [ 410 ] Regensburg Regensburg University [ 198 , 255 , 292 , 296 , 299 ] Greece Athens General HS KAT [ 155 , 384 , 646 ] Thessaloniki Arthroplasty RG Thessaloniki (ART) [ 2 , 12 , 406 , 455 , 647 ] Italy Emilia-Romanga Register of Orthopaedic Prosthetic Implant (RIPO) [ 24 , 26 , 39 , 43 , 57 , 145 , 164 , 189 , 231 , 288 , 297 , 468 , 476 , 482 , 491 , 502 , 506 , 508 , 527 , 540 , 562 , 563 , 569 , 585 , 592 , 597 , …”
Section: Resultsmentioning
confidence: 99%
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“…ORTHOTEP University HS Carl Gustav Carus [ 109 , 619 ] 2. Dresden Hip Surgery Registry [ 52 , 196 ] Heidelberg University of Heidelberg [ 410 ] Regensburg Regensburg University [ 198 , 255 , 292 , 296 , 299 ] Greece Athens General HS KAT [ 155 , 384 , 646 ] Thessaloniki Arthroplasty RG Thessaloniki (ART) [ 2 , 12 , 406 , 455 , 647 ] Italy Emilia-Romanga Register of Orthopaedic Prosthetic Implant (RIPO) [ 24 , 26 , 39 , 43 , 57 , 145 , 164 , 189 , 231 , 288 , 297 , 468 , 476 , 482 , 491 , 502 , 506 , 508 , 527 , 540 , 562 , 563 , 569 , 585 , 592 , 597 , …”
Section: Resultsmentioning
confidence: 99%
“…The “Register of Orthopaedic Prosthetic Implant (RIPO) of Emilia-Romagna region” published 30 papers from 2002 to 2022 [ 24 , 645 ]. Among them, twenty-eight were cohort studies [ 24 , 26 , 39 , 43 , 57 , 145 , 164 , 189 , 231 , 288 , 297 , 482 , 491 , 502 , 506 , 508 , 527 , 540 , 562 , 563 , 569 , 585 , 592 , 597 , 599 , 624 , 630 , 645 ], one was RCT [ 476 ] and one registry protocol [ 468 ]. Of these 30 studies, 16 were survival [ 26 , 164 , 189 , 231 , 288 , 482 , 491 , 502 , 508 , 527 , 540 , 563 , 569 , 585 , 592 , 599 ], six analysed implant types [ 24 , 43 , 297 , 506 , 624 , 645 ], and two studied postoperative complications [ 597 , 630 ].…”
Section: Resultsmentioning
confidence: 99%
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“…Of concern is that 11 genes are upregulated both in postmortem brains and induced coma: Cdc42 , Csnk2a1 , Gadd45a , Prdx2 , Rasa1 , Tnfrsf14 , Tpr , Klkb1 , Bcl2 , Ier3 , and Zfand2a [ 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. Further, near-death experiences and induced coma that is required in numerous conditions associated with cardiopulmonary arrest with multiple organ failure, are always accompanied by a loss of consciousness [ 119 , 120 , 121 , 122 , 123 , 124 ].…”
Section: Discussionmentioning
confidence: 99%