Effect of different combination of maternal and postnatal diet on adipose tissue morphology in male rat offspring

Šnajder, Darija; Kačarević, Željka Perić; Grgić, Anđela; Bijelić, Nikola; Fenrich, Matija; Belovari, Tatjana; Radić, Radivoje

doi:10.1080/14767058.2017.1419181

Cited by 6 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other work has shown that offspring of mothers consuming an obesogenic diet during gestation may be more prone to dietary-induced changes postnatally. For instance, rat offspring exposed to maternal obesity show greater morphological changes, including enhanced adipocyte hyperplasia in response to a postnatal high-fat diet [ 94 ]. Finally, some research suggests that programmed changes in offspring adipose biology may be permanent, as an exercise intervention in mothers fed a high-fat diet did not prevent the increased adiposity or trigger beneficial changes in insulin signaling component expression in their fetuses [ 95 ].…”

Section: Adipose Tissuesmentioning

confidence: 99%

Developmental programming of offspring adipose tissue biology and obesity risk

Rodgers

Sferruzzi‐Perri

2021

Int J Obes

View full text Add to dashboard Cite

Obesity is reaching epidemic proportions and imposes major negative health crises and an economic burden in both high and low income countries. The multifaceted nature of obesity represents a major health challenge, with obesity affecting a variety of different organs and increases the risk of many other noncommunicable diseases, such as type 2 diabetes, fatty liver disease, dementia, cardiovascular diseases, and even cancer. The defining organ of obesity is the adipose tissue, highlighting the need to more comprehensively understand the development and biology of this tissue to understand the pathogenesis of obesity. Adipose tissue is a miscellaneous and highly plastic endocrine organ. It comes in many different sizes and shades and is distributed throughout many different locations in the body. Though its development begins prenatally, quite uniquely, it has the capacity for unlimited growth throughout adulthood. Adipose tissue is also a highly sexually dimorphic tissue, patterning men and women in different ways, which means the risks associated with obesity are also sexually dimorphic. Recent studies show that environmental factors during prenatal and early stages of postnatal development have the capacity to programme the structure and function of adipose tissue, with implications for the development of obesity. This review summarizes the evidence for a role for early environmental factors, such as maternal malnutrition, hypoxia, and exposure to excess hormones and endocrine disruptors during gestation in the programming of adipose tissue and obesity in the offspring. We will also discuss the complexity of studying adipose tissue biology and the importance of appreciating nuances in adipose tissue, such as sexual dimorphism and divergent responses to metabolic and endocrine stimuli. Given the rising levels of obesity worldwide, understanding how environmental conditions in early life affects adipose tissue phenotype and the subsequent development of obesity is of absolute importance.

show abstract

Section: Adipose Tissuesmentioning

confidence: 99%

Developmental programming of offspring adipose tissue biology and obesity risk

Rodgers

Sferruzzi‐Perri

2021

Int J Obes

View full text Add to dashboard Cite

show abstract

“…It involved ten female Sprague Dawley rats randomly divided into two groups and fed either a diet rich in saturated fatty acids (HFD group) or control diet (CD group). The same diets were fed to their male offspring (n = 6 in each group) after birth and during the 3-week lactation period, as previously described [ 27 , 28 , 29 ]. The flowchart of the experimental procedure is shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

“…Male rat offspring were euthanized at the age of 22 weeks. They were anaesthetized with a combination of ketamine and midazolam (Ketanest S, 25 mg/mL, 3 mL, Midazolam, 5 mg/mL, 1 mL, Pfizer, NY, USA) as described before [ 29 ]. Three compartments of WAT were isolated: subcutaneous, epididymal, and perirenal, and immediately stored in plastic tubes with formalin for fixation for a minimum of 12 h. After fixation, tissue samples were embedded in paraffin blocks, and then cut to 6 µm using a microtome (Leica, Vienna, Austria).…”

Section: Methodsmentioning

confidence: 99%

Alteration of Collagen Content and Macrophage Distribution in White Adipose Tissue under the Influence of Maternal and Postnatal Diet in Male Rat Offspring

Mujkić

Čekić

et al. 2023

Medicina

Self Cite

View full text Add to dashboard Cite

Background and Objectives: The extracellular matrix is important for adipose tissue growth, and numerous interactions between adipocytes and extracellular matrix components occur during adipose tissue development. The main objective of this study was to investigate the interaction and influence of maternal and postnatal diet on adipose tissue remodeling in Sprague Dawley offspring. Materials and Methods: 10 Sprague Dawley females were randomly divided into two groups at nine weeks of age and fed a standard laboratory diet or high-fat diet for six weeks. Then, they were mated, and after birth, their male rat offspring were divided into four subgroups according to diet. After euthanizing the offspring at 22 weeks of age, samples of subcutaneous, perirenal and epididymal adipose tissue were collected. Sections were stained with Mallory’s trichrome and analyzed by immunohistochemistry for CD68+ and CD163+ cells. Results: Staining of extracellular components showed higher collagen deposition in the perirenal and epididymal depot of offspring fed a high-fat diet. The number of CD163/CD68+ cells in the perirenal adipose tissue was lower in the CD-HFD group compared with other groups, and in the subcutaneous fat pad when the groups with modified diet were compared with those on non-modified diet. Conclusion: Morphological changes in adipose tissue, increased collagen deposition, and changes in macrophage polarization may be related to intergenerational changes in diet.

show abstract

“…In animal models, in utero exposure to a diet rich in fats with or without prior maternal obesity, predisposes offspring to have increased body weight (46)(47)(48), increases the risk of developing obesity (46), increases tendencies to consume other substances of abuse such as nicotine and ethanol (47,49,50), and is associated with an increase in the incidence of psychiatric disorders ( Figure 2) (51-53). Ingestion of a HFD during pregnancy increases lipid accumulation in the placenta (54), while in offspring decreases the circulation of essential fatty acids (54), and increases the levels of triglycerides and adipocyte size (55,56). Prenatal HFD paired with a postnatal HFD regime can cause several effects in offspring that is exerted on a macro and microscale level, including a reduction in the variation of DNA methylation in peripheral organs and changes the expression of genes involved in inflammation and RNA processing (48).…”

Section: Dietary Fat On Stimulating Neurochemical Systems In the Hypomentioning

confidence: 99%

Behavioral Feeding Circuit: Dietary Fat-Induced Effects of Inflammatory Mediators in the Hypothalamus

Poon

2020

Front. Endocrinol.

View full text Add to dashboard Cite

Excessive dietary fat intake has extensive impacts on several physiological systems and can lead to metabolic and nonmetabolic disease. In animal models of ingestion, exposure to a high fat diet during pregnancy predisposes offspring to increase intake of dietary fat and causes increase in weight gain that can lead to obesity, and without intervention, these physiological and behavioral consequences can persist for several generations. The hypothalamus is a region of the brain that responds to physiological hunger and fullness and contains orexigenic neuropeptide systems that have long been associated with dietary fat intake. The past fifteen years of research show that prenatal exposure to a high fat diet increases neurogenesis of these neuropeptide systems in offspring brain and are correlated to behavioral changes that induce a pro-consummatory and obesogenic phenotype. Current research has uncovered several potential molecular mechanisms by which excessive dietary fat alters the hypothalamus and involve dietary fatty acids, the immune system, gut microbiota, and transcriptional and epigenetic changes. This review will examine the current knowledge of dietary fat-associated changes in the hypothalamus and the potential pathways involved in modifying the development of orexigenic peptide neurons that lead to changes in ingestive behavior, with a special emphasis on inflammation by chemokines.

show abstract

Effect of different combination of maternal and postnatal diet on adipose tissue morphology in male rat offspring

Abstract: Together with our previously published data, our results lead to the conclusion that alteration of postnatal diet can lead to TNF-α and adipocyte morphology changes.

Cited by 6 publications

References 43 publications

Developmental programming of offspring adipose tissue biology and obesity risk

Developmental programming of offspring adipose tissue biology and obesity risk

Alteration of Collagen Content and Macrophage Distribution in White Adipose Tissue under the Influence of Maternal and Postnatal Diet in Male Rat Offspring

Behavioral Feeding Circuit: Dietary Fat-Induced Effects of Inflammatory Mediators in the Hypothalamus

Contact Info

Product

Resources

About