Effect of Different Composition of Polyethylene Oxide‐Polypyrrole (PEO‐PPy) Nanofiber Mats on Antibacterial and Biocompatibility Properties

Abstract

Electrospun nanofibers are unique one-dimensional materials with high surface area to volume ratio which can be used in various applications including in antibacterial application. In this study, we demonstrated a simple fabrication of polyethylene oxide-polypyrrole (PEO-PPy) composite nanofibers with antibacterial properties. The polymerization of pyrrole was conducted using ammonium persulfate (APS) initiator at ambient temperature for 24 h. The resulting PEO-PPy nanofibers were then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), fourier transform infrared (FTIR), and tensile tests. The morphology of nanofibers observed by SEM revealed that the minimum concentration of PEO was 8 wt % to obtain the bead-free nanofibers. Meanwhile, variation of pyrrole concentration does not alter the morphology of nanofibers significantly. The crystallinity of the nanofibers increased with increasing the PEO amount indicated by two typical peaks located at 2θ = 19°and 23°, respectively. On the other hand, polypyrrole contributed the antibacterial properties significantly to the nanofibers and as a result, the antibacterial activity determined by UV-Vis spectrophotometer increased dramatically with increasing pyrrole concentration from 0.1 to 0.2, 0.3, 0.4, and 0.5 mM. The electrospun nanofiber mats exhibited good antibacterial properties on E. coli and biocompatibility properties on L929 fibroblasts cell.

Electrospun Nanofiber Mats with Embedded Zinc Oxysulfide for Photoreduction of Nitrobenzene to Aniline under Mild Condition

“…In the FTIR spectrum of PEO, the peaks at 3441 and 2883 cm –1 referred to the functional groups of stretching -OH and CH sp 3 , respectively . The organic functionality peaks of bending CH 2 , stretching C–O–C, bending C–H, and stretching C–C were located at 1445, 1106, 958, and 849 cm –1 , respectively. , In the presence of ZnO in PEO nanofibers, there was an additional peak observed at a wavelength of 438 cm –1 corresponding to the stretching vibration of Zn–O. , Meanwhile, the presence of ZnS in PEO nanofibers was indicated by the Zn-S stretching vibration peak at 610 cm –1 . Furthermore, the stretching vibration peak of Zn­(O,S) was found at 554 cm –1 in between those of ZnO and ZnS peaks.…”

“…A desired amount of Zn(NO 3 ) 2 was added to the viscous solution. Then, the mixture solution was transferred into a syringe tube equipped with a stainless-steel needle (Ø = 0.154 mm), and the electrospinning process was carried out at a constant voltage of 20 kV and a distance of 10 cm between the tip of the needle and drum collector (covered with aluminum foil) . The as-electrospun nanofiber was annealed in a muffle furnace at 350 °C for 2 h to obtain a PEO-containing ZnO (PZO) nanofiber.…”

“…Then, the mixture solution was transferred into a syringe tube equipped with a stainless-steel needle (Ø = 0.154 mm), and the electrospinning process was carried out at a constant voltage of 20 kV and a distance of 10 cm between the tip of the needle and drum collector (covered with aluminum foil). 20 The as-electrospun nanofiber was annealed in a muffle furnace at 350 °C for 2 h to obtain a PEO-containing ZnO (PZO) nanofiber. To synthesize ZnS embedded in PEO nanofiber (PZS) and PZOS nanofibers, a desired amount of thiourea was added into the mixture solution prior to the electrospinning process.…”

Synthesis and application of polypyrrole nanofibers: a review

“…On the other hand, pure polypyrrole is difficult to be electrospun into nanofibers due to its low solubility and dispersability. Additives such as co-solvents, surfactants, and polymer carriers are needed to prepare polypyrrole solutions that are suitable for electrospinning, 23,24 which may significantly alter the conductivity of the nanofibers. Many attempts have been made to circumvent the obstacle of polypyrrole solubility, for example, polypyrrole with improved solubility in organic solvents was synthesized by the addition of functional dopants, i.e.…”

“…On the other hand, pure polypyrrole is difficult to be electrospun into nanobers due to its low solubility and dispersability. Additives such as co-solvents, surfactants, and polymer carriers are needed to prepare polypyrrole solutions that are suitable for electrospinning, 23,24 which may signicantly alter the conductivity of the nanobers. Many attempts have been made to circumvent the obstacle of polypyrrole solubility, for example, polypyrrole with improved solubility in organic solvents was synthesized by the addition of functional dopants, i.e., [di(2-ethylhexyl)sulfosuccinic acid sodium salt], butylnaphthalene sulfonic acid sodium salt, and dodecylbenzene sulfonic acid sodium salt; 25 upon further functionalization with chlorosulfonic acid, the water solubility of the as-obtained polypyrrole can reach 3 wt%, due to which it can be utilized for the electrospinning process in the aqueous phase.…”