Effect of Different Controlled Ovarian Hyper-Stimulation Protocols on Endometrial Receptivity Parameters of Icsi Programs.

Abstract

Background:Infertility is defined by demographers as childlessness in a population of women at a reproductive age, currently, female fertility normally reaching the peak at age of 24 years and declines after the age of 30-32. Age, overweight, smoking, abnormal pituitary-ovarian hormones all are considered as risk factors of infertility. IVF technique was to overcome this condition by using patients' oocytes and sperms. A good number of high quality oocytes are required for maximizing the success rates with IVF cycles, since success rates correspond to the number of retrieved oocytes. Gonadotropic releasing hormones used for suppression of pituitary hormones with exogenous Gonadotropic hormones administration can achieve multifollicular stimulation in different protocols. Objective: Comparing the effect of different controlled ovarian hyperstimulation protocols on the endometrial receptivity markers. Methods: A total of eighty patients undergoing IVF/ICSI cycle were evaluated. One out of three types of controlled ovarian hyperstimulation (COH) protocols had been chosen for each patient according to her age, history and hormonal assay. At day of embryo transfer blood sample was taken to measure the level of VEGF, also Doppler ultrasonography to measure the resistance index (RI), pulsatility index (PI), systolic velocity/diastolic velocity (V S /V d ) was done. Results: There were no significant difference between the three types of ovarian stimulation protocols, still the picture drawn suggests that GnRH antagonists are slightly less efficacious than GnRH agonists in long protocols. Conclusion: Different types of controlled ovarian hyperstimulation protocols have no significant effects on endometrial receptivity parameters.