Effect of different dietary fats on hepatic gene expression in transition dairy goats

Agazzi, Alessandro; Invernizzi, G.; Campagnoli, A.; Ferroni, M.; Fanelli, Andrea; Cattaneo, D.; Galmozzi, Andrea; Crestani, Maurizio; Dell’Orto, V.; Savoini, G.

doi:10.1016/j.smallrumres.2010.04.027

Cited by 20 publications

(15 citation statements)

References 38 publications

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“…In general, these results are in agreement with Adibmoradi et al (2012) who defined that blood plasma glucose, triglycerides, total cholesterol, HDL and LDL did not significantly differ among goat kids fed rations containing different levels of energy. Moreover, these results are supported with the conclusions of Agazzi et al (2010) who reported that different dietary fatty acids supplementation to goat rations did not affect blood plasma parameters. In contrast to these findings, Miguel et al (2012) found that serum concentrations of cholesterol was higher in group fed ration contained high energy than fed low energy.…”

Section: Blood Metabolitessupporting

confidence: 89%

Influence of Feeding Non-Conventional Energy Sources on Pubertal Phases, Blood Metabolites and Fattening of Zaraibi Male Kids

Behery

Khalifa

Mahrous

2014

Journal of Animal and Poultry Production

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The aim of this study was to investigate the effect of non-traditional dietary energy as protected fat (PF) and corn steep liquor (CSL) and combination between PF and CSL on upbringing male kids as sires for flock or fattening for marketing. Hence, testis development during pubertal stages, blood metabolites and fattening of Zaraibi male kids were studied. Twenty Zaraibi male kids with an average initial body weight of 15.69 kg and aged 135 days were used. Kids were assigned to four equal groups (N=5 /group) and received non-conventional energy treatments as E1 (control), E2, E3 and E4 contained 10.99, 11.92, 11.63 and 11.96 MJ/kg, respectively. The basal control diet E1 included concentrate feed mixture (CFM) + rice straws (RS). While, E2, E3 and E4 consisted of CFM + RS supplemented with 5% PF, 5% CSL or 2.5% PF + 2.5% CSL, respectively. The stages of age during puberty, changing of body weight, scrotal circumference, testicular volume and testosterone concentration were evaluated during pubertal phases. When kids reached puberty, semen characteristics were investigated. At the end of the experiment, blood samples were collected to assay glucose, triglycerides, total cholesterol, HDL and LDL concentrations. Moreover, fattening performance was estimated for live body weight, average daily weight gain, dry matter intake, feed conversion ratio, water consumption, feed cost and economical efficiency. The results obtained during all pubertal stages, indicated that the kids which received E4 diet had the highest (P<0.05) testicular growth measurements (scrotal circumference and volume), testosterone levels and semen characteristics compared to the other energy levels. Plasma glucose, triglycerides, total cholesterol, HDL and LDL concentrations did not significantly differ among all energy diets. Also, E4 diet showed a significantly (P<0.05) higher live body weight, average daily weight gain and economical efficiency than kids fed other dietary energy. On the contrary, kids fed E4 achieved lower (P<0.05) dry matter intake, feed conversion ratio, water consumption and feed cost than other kids fed different energy diets. Based on results of the present study, it could be safely concluded that supplemented combination between PF and CSL to male kid rations indicated the best testicular development during pubertal stages, semen characteristics at puberty, blood metabolites and feedlot performance.

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Section: Blood Metabolitessupporting

confidence: 89%

Influence of Feeding Non-Conventional Energy Sources on Pubertal Phases, Blood Metabolites and Fattening of Zaraibi Male Kids

Behery

Khalifa

Mahrous

2014

Journal of Animal and Poultry Production

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“…() showed that gene expression in the liver of ruminants could be affected not to the n‐3 FA itself, but to liver concentration of saturated FAs. Palmitic and stearic acid, which are the main FAs in lipid deposits, can be strongly mobilized around calving (Agazzi et al., ). Therefore, hepatic FA oxidation could be particularly responsive to supraphysiological concentrations of these FAs.…”

Section: Discussionmentioning

confidence: 99%

“…The lack of an effect of linseed supplementation on key metabolic gene expression and TAG concentrations could be due to the limited uptake of ALA by the intestine [on most diets, biohydrogenation of ALA in ruminants varies between 85% and 100% (Glasser et al, 2008)], which might be below a threshold needed to alter hepatic and adipose gene expression. Also, Agazzi et al (2010) showed that gene expression in the liver of ruminants could be affected not to the n-3 FA itself, but to liver concentration of saturated FAs. Palmitic and stearic acid, which are the main FAs in lipid deposits, can be strongly mobilized around calving (Agazzi et al, 2010).…”

mentioning

confidence: 99%

Dietary effects of linseed on fatty acid composition of milk and on liver, adipose and mammary gland metabolism of periparturient dairy cows

Mach

Zom

Widjaja

et al. 2013

Animal Physiology Nutrition

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SummaryDuring the transition period in dairy cows, drastic adaptations within and between key tissues and cell types occur in a coordinated manner to support late gestation, the synthesis of large quantities of milk and metabolic homoeostasis. The start of lactation coincides with an increase of triacylglycerols in the liver, which has been associated with several economically important diseases in dairy cows (i.e. hepatic lipidiosis, mastitis). The polyunsaturated fatty acids have been used to improve liver metabolism and immune function in the mammary gland. Therefore, the effects of dietary linseed supplementation on milk quality and liver, adipose and mammary gland metabolism of periparturient dairy cows were studied in 14 cows that were randomly assigned to control or linseed supplementation. Animals were treated from 3 weeks antepartum until 6 weeks post-partum. Linseed did not modify dry matter intake, but increased milk yield and lactose yield, and decreased milk fat concentration, which coincided with lower proportion of C16 and higher proportions of stearic acid, conjugated linoleic acid and a-linolenic acid in milk fat. Linseed supplementation did not significantly change the expression of key lipid metabolism genes in liver and adipose tissues, except of glucose transporter 2 (GLUT2) in liver, which was increased in cows supplemented with linseed, suggesting that more glucose was secreted and probably available for lactose synthesis compared with cows fed control diet. Large adaptations of transcription occurred in the mammary gland when dairy cows were supplemented with linseed. The main affected functional modules were related to energy metabolism, cell proliferation and remodelling, as well as the immune system response.

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“…where PPARs have a strong effect, and their ability to be activated by dietary fatty acids makes them a strong candidate for nutrigenomic effects in ruminants. The PPARs exert similar effects as observed in dairy cows in other ruminants, for instance, PPARγ has been associated with adipogenic effects in beef, cows [16,17], and goats [18] as well as fatty acid oxidation by PPARα in transition dairy goats [19].…”

Section: Mediators Of Nutrient-gene Interactions In Ruminantsmentioning

confidence: 72%

Gene Regulation in Ruminants: A Nutritional Perspective

Osorio¹,

Moisá²

2019

Gene Expression and Control

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This chapter will focus on cellular regulatory programs implemented by the ruminant physiology in order to respond to external stimuli such as nutrition as well as important physiological events such as parturition. The increasing adoption of "omics" technologies and bioinformatics in nutrition and physiology in ruminant research have allowed us to delineate a clearer picture on what regulates major biological process at a molecular level such as milk synthesis and meat quality and fatty acid composition as well as pathological conditions such as ketosis, mastitis, and heat stress. The assembly of such plethora of information in a blend among nutritional research, molecular biology, and novel tools to study the response of the genome to nutrition has led to emerging disciplines such as nutritional genomics or "nutrigenomics."

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Effect of different dietary fats on hepatic gene expression in transition dairy goats

Cited by 20 publications

References 38 publications

Influence of Feeding Non-Conventional Energy Sources on Pubertal Phases, Blood Metabolites and Fattening of Zaraibi Male Kids

Influence of Feeding Non-Conventional Energy Sources on Pubertal Phases, Blood Metabolites and Fattening of Zaraibi Male Kids

Dietary effects of linseed on fatty acid composition of milk and on liver, adipose and mammary gland metabolism of periparturient dairy cows

Gene Regulation in Ruminants: A Nutritional Perspective

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