Effect of Different Doses of Vitamin D on the Intestinal Flora of Babies with Eczema: An Experimental Study

Li, Youping; Meng, Yonggang; Ran, Zhiling; Wang, Junxia; Ma, Wujie; Sheng, Qiaoni

doi:10.3390/life12091409

Cited by 3 publications

(14 citation statements)

References 37 publications

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“…Vitamin D increased the microbial diversity and richness and showed a significant beta diversity [36,37,40,43]. On the contrary, a study in infants with eczema showed a significant low microbial diversity with high doses of Vitamin D but had similarities between the low-Vitamin D-supplemented group and healthy infants [40]. A positive association with the infant gut microbial community with Vitamin D status was observed in some of these studies.…”

Section: Association Of Vitamin D With Microbial Composition and Dive...mentioning

confidence: 84%

“…Two of these studies containing exclusively breast-fed infants showed a relation between Vitamin D supplementation and alpha and beta diversity. Vitamin D increased the microbial diversity and richness and showed a significant beta diversity [36,37,40,43]. On the contrary, a study in infants with eczema showed a significant low microbial diversity with high doses of Vitamin D but had similarities between the low-Vitamin D-supplemented group and healthy infants [40].…”

Section: Association Of Vitamin D With Microbial Composition and Dive...mentioning

confidence: 90%

“…Vitamin D levels increased the co-abundance of Firmicutes (Lachnospiraceae/Clostridiales) in these children and decreased Bacteroides. Firmicutes were significantly lower in Vitamin D-deficient children [42] but increased after supplementation in adolescent girls [40]. For breast-fed infants with 4 months supplementation of Vitamin D, they showed a significant increase in the abundance of Actinobacteria and a decrease in Bacteroidetes [37] in comparison with breast-fed infants without Vitamin D supplementation.…”

Section: Vitamin D Effects On the Phylamentioning

confidence: 92%

“…Overall, one study included supplementing high doses of Vitamin D to adolescent girls 50,000 IU/week [39]. One study included providing Vitamin D 400 IU/day or Vitamin D 400 IU/day with Vitamin D 200 or 400 IU/day with another dosage of Vitamin D 400 IU/day or 400 IU/day with 800 IU/day [40]. One out of the 10 studies included Vitamin D levels in 4-to-14-year-old children [41].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…There was some evidence that Vitamin D was associated with bacterial community composition. Four studies [36,37,40,43] determined that supplementation with Vitamin D 3 was associated with a shift in microbial composition. Two of these studies containing exclusively breast-fed infants showed a relation between Vitamin D supplementation and alpha and beta diversity.…”

Section: Association Of Vitamin D With Microbial Composition and Dive...mentioning

confidence: 99%

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Immunomodulatory Role of Vitamin D on Gut Microbiome in Children

et al. 2023

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Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the immune system. We have systematically collated relevant studies from different databases concerning changes in the gut microbiome of children from infants to 18 years old associated with Vitamin D and the immunological pathways. The studies utilized 16S rRNA sequencing analysis of fecal matter with or without Vitamin D supplementation and Vitamin D levels. Ten studies were selected for the review, among which eight studies showed significant alterations in the gut microbiome related to Vitamin D supplementation or Vitamin D levels. The taxa of the phylum Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria are the most altered in these studies. The alteration of the taxa alters the Th1 and Th2 pathways and changes the immune response. We will discuss how Vitamin D may contribute to the activation of immune pathways via its effects on intestinal barrier function, microbiome composition, and/or direct effects on immune responses. In conclusion, the studies examined in this review have provided evidence that Vitamin D levels may have an impact on the composition of children’s gut microbiomes.

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Section: Association Of Vitamin D With Microbial Composition and Dive...mentioning

confidence: 84%

Section: Association Of Vitamin D With Microbial Composition and Dive...mentioning

confidence: 90%

Section: Vitamin D Effects On the Phylamentioning

confidence: 92%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Association Of Vitamin D With Microbial Composition and Dive...mentioning

confidence: 99%

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Immunomodulatory Role of Vitamin D on Gut Microbiome in Children

et al. 2023

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Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy

Wu,

Wang,

Wei

et al. 2024

Physiol Res

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It was to investigate the clinical efficacy of the combination therapy of fluticasone propionate inhalation aerosol and vitamin D (VD) in pediatric bronchial asthma (BA) and analyze the correlation between serum 25-(OH)-D3 levels and immune function, as well as calcium-phosphorus metabolism. A total of 110 patients with BA were recruited. Regarding treatment plan, patients were randomly rolled into a single-drug treatment group (SDT, treated with fluticasone propionate inhalation aerosol alone) and a dual-drug treatment group (TDT, treated with the combination of fluticasone propionate inhalation aerosol and VD). The changes in serum 25-(OH)-D3 levels, immunoglobulins, T lymphocyte subsets, and inflammatory cytokine levels in children with BA under different treatment modalities were compared. Clinical symptom disappearance, asthma control, and quality of life (QoL) were assessed, and the total effective rate and adverse reactions (ARs) were compared. A control group consisting of 60 healthy children who underwent concurrent physical examinations was included. The differences in serum 25-(OH)-D3 levels, immunoglobulins, and T lymphocyte subset levels between children with BA and healthy controls were compared, and their correlations were analyzed. The TDT group showed a drastic reduction in the disappearance time of lung wheezing and dyspnea relative to the SDT group. Furthermore, the TDT group exhibited notable improvements in lung function parameters, including forced vital capacity (FVC), forced expiratory volume at one second (FEV1), FEV1/FVC, and peak expiratory flow (PEF). Blood gas analysis revealed a great decrease in PaCO2 and an increase in PaO2. The Childhood Asthma Control Test (C-ACT) scores for asthma control and Pediatric Asthma Quality of Life Questionnaire (PAQLQ) scores for QoL showed marked increases in the TDT group. Moreover, the TDT group demonstrated notable increases in serum 25-(OH)-D3 levels, immunoglobulins (IgA, IgG, and IgM), T lymphocyte subsets (CD4+ and CD8+), as well as blood calcium and phosphorus levels. Additionally, the TDT group exhibited a prominent increase in the anti-inflammatory cytokine interleukin (IL)-10 level and a drastic decrease in the pro-inflammatory cytokines IL-6 and tumor necrosis factor alpha (TNF-α) levels (all P<0.05). The total effective rates of treatment in the SDT group and TDT group were 83.64 % and 96.36 %, respectively, with AR rates of 16.36 % and 7.27 %. The TDT group exhibited a superior total effective rate and an inferior incidence of ARs to the SDT group (both P<0.05). Additionally, in contrast to the control group, the BA group showed notable decreases in serum 25-(OH)-D3 levels, immunoglobulins (IgA, IgG, and IgM), T lymphocyte subsets (CD4+, CD8+, and CD4+/CD8+), as well as blood calcium and phosphorus levels (all P<0.05). Prior to treatment, there was a positive correlation between serum 25-(OH)-D3 levels and immunoglobulins (IgA, IgG, and IgM), T lymphocyte subsets (CD4+ and CD8+), as well as blood calcium and phosphorus levels in children with BA (P<0.05). In patients with BA, combined treatment with inhaled fluticasone propionate aerosol and VD may have a regulatory effect on serum 25-hydroxyVD levels, immune function, and calcium-phosphate metabolism. The correlation between serum 25-(OH)-D3 levels and immune function, as well as calcium-phosphate metabolism, suggested that VD may play a crucial role in the immune regulation and calcium-phosphate metabolism of BA.

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Increased Cadmium Load, Vitamin D Deficiency, and Elevated FGF23 Levels as Pathophysiological Factors Potentially Linked to the Onset of Acute Lymphoblastic Leukemia: A Review

Djulejic,

Ivanovski,

Cirovic

et al. 2024

JPM

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The preventability of acute lymphocytic leukemia during childhood is currently receiving great attention, as it is one of the most common cancers in children. Among the known risk factors so far are those affecting the development of gut microbiota, such as a short duration or absence of breastfeeding, cesarean section, a diet lacking in short-chain fatty acids (SCFAs), the use of antibiotics, absence of infection during infancy, and lack of pets, among other factors. Namely, it has been shown that iron deficiency anemia (IDA) and lack of vitamin D may cause intestinal dysbiosis, while at the same time, both increase the risk of hematological malignancies. The presence of IDA and vitamin D deficiency have been shown to lead to a decreased proportion of Firmicutes in stool, which could, as a consequence, lead to a deficit of butyrate. Moreover, children with IDA have increased blood concentrations of cadmium, which induces systemic inflammation and is linked to the onset of an inflammatory microenvironment in the bone marrow. Finally, IDA and Cd exposure increase fibroblast growth factor 23 (FGF23) blood levels, which in turn suppresses vitamin D synthesis. A lack of vitamin D has been associated with a higher risk of ALL onset. In brief, as presented in this review, there are three independent ways in which IDA increases the risk of acute lymphocytic leukemia (ALL) appearance. These are: intestinal dysbiosis, disruption of vitamin D synthesis, and an increased Cd load, which has been linked to systemic inflammation. All of the aforementioned factors could generate the appearance of a second mutation, such as ETV6/RUNX1 (TEL-AML), leading to mutation homozygosity and the onset of disease. ALL has been observed in both IDA and thalassemia. However, as IDA is the most common type of anemia and the majority of published data pertains to it, we will focus on IDA in this review.

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Effect of Different Doses of Vitamin D on the Intestinal Flora of Babies with Eczema: An Experimental Study

Cited by 3 publications

References 37 publications

Immunomodulatory Role of Vitamin D on Gut Microbiome in Children

Immunomodulatory Role of Vitamin D on Gut Microbiome in Children

Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy

Increased Cadmium Load, Vitamin D Deficiency, and Elevated FGF23 Levels as Pathophysiological Factors Potentially Linked to the Onset of Acute Lymphoblastic Leukemia: A Review

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