Effect of different fractions of Swertia chirayita on the blood sugar level of albino rats

Sekar, B. Chandra; Mukherjee, B.; Chakravarti, R.B.; Mukherjee, S. K.

doi:10.1016/0378-8741(87)90127-9

Cited by 30 publications

(4 citation statements)

References 2 publications

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“…Swertia chirata has also been shown to lower blood sugar 11 and to possess antiulcerogenic 12 and antihepatotoxic activities. 13 The rind of raw C. papaya fruit showed the highest antimalarial activity of the plant extracts tested.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India.

Bhat¹,

Surolia²

2001

The American Journal of Tropical Medicine and Hygiene

107

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Abstract. In an attempt to search for new antimalarial drugs, we studied plants used by traditional healers of southwest India to treat malaria. Aqueous and organic solvent extracts obtained from specific parts of the plants Swertia chirata, Carica papaya, and Citrus sinensis were tested on malaria strain Plasmodium falciparum FCK 2 in vitro. The temperatures of extraction were the same as that used by the traditional healers in their plant preparations. Visual evaluation of the antimalarial activity of the plant extracts on thin blood smears was followed by quantification of the activity by use of [ 35 S]-methionine incorporation into parasite proteins to determine the value that inhibits 50% (IC 50 ). Among the 3 plants tested, 2 had significant inhibitory effect on P. falciparum in vitro.

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Section: Discussionmentioning

confidence: 99%

In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India.

Bhat¹,

Surolia²

2001

The American Journal of Tropical Medicine and Hygiene

107

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“…Mangiferin is also reported to have anti-diabetic, antiatherosclerotic (Pardo-Andreu et al, 2008 ), anticancer, anti-HIV (Guha et al, 1996 ), antiparkinson (Kavitha et al, 2013 ), and chemopreventive (Yoshimi et al, 2001 ) activities. Swerchirin is known to be antimalarial, hypoglycemic (Bajpai et al, 1991 ; Saxena et al, 1996 ), hepatoprotective, pro-heamatopoietic (Ya et al, 1999 ), with blood glucose lowering activity (Sekar et al, 1987 ; Saxena et al, 1991 ) and weak chemo preventive pharmacological effects (Hirakawa et al, 2005 ). Swerchirin at different concentrations (1, 10, and 100 μM) significantly enhanced glucose stimulated insulin release from isolated islets (Saxena et al, 1993 ).…”

Section: Phytochemistrymentioning

confidence: 99%

A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal Plant

2016

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Swertia chirayita (Gentianaceae), a popular medicinal herb indigenous to the temperate Himalayas is used in traditional medicine to treat numerous ailments such as liver disorders, malaria, and diabetes and are reported to have a wide spectrum of pharmacological properties. Its medicinal usage is well-documented in Indian pharmaceutical codex, the British, and the American pharmacopeias and in different traditional medicine such as the Ayurveda, Unani, Siddha, and other conventional medical systems. This ethnomedicinal herb is known mostly for its bitter taste caused by the presence of different bioactive compounds that are directly associated with human health welfare. The increasing high usage of Swertia chirayita, mostly the underground tissues, as well as the illegal overharvesting combined with habitat destruction resulted in a drastic reduction of its populations and has brought this plant to the verge of extinction. The increasing national and international demand for Swertia chirayita has led to unscrupulous collection from the wild and adulteration of supplies. The aim of this review is to provide a synthesis of the current state of scientific knowledge on the medicinal uses, phytochemistry, pharmacological activities, safety evaluation as well as the potential role of plant biotechnology in the conservation of Swertia chirayita and to highlight its future prospects. Pharmacological data reported in literature suggest that Swertia chirayita shows a beneficial effect in the treatment of several ailments. However, there is lack of adequate information on the safety evaluation of the plant. The pharmacological usefulness of Swertia chirayita requires the need for conservation-friendly approaches in its utilization. Providing high-quality genetically uniform clones for sustainable use and thereby saving the genetic diversity of this species in nature is important. In this regard, plant biotechnological applications such as micropropagation, synthetic seed production, and hairy root technology can play a significant role in a holistic conservation strategy. In addition to micropropagation, storage of these valuable genetic resources is equally important for germplasm preservation. However, more advanced research is warranted to determine the activities of bioactive compounds in vitro and in vivo, establish their underlying mechanisms of action and commence the process of clinical research.

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“…In order to understand the hypoglycemic potential of ethanolic extract of S. chirayita , streptozotocin- nicotinamide influenced wistar albino mice (30–35 gm b/w) model was implemented by Renu et al [ 72 ] and excellent serum sugar, cholesterol as well as triglyceride reducing activity was observed during implementation of such extract. In a similar type of research investigation by Sekar et al [ 24 ], 95% ethanolic extract and four hexane fraction extractions of Swertiu chirayita were tested using albino rats for blood sugar level lowering ability. The hexane fraction showed important properties of reducing blood sugar in both fed and tolbutamide influenced models relative to the appropriate controls.…”

Section: Therapeutic Potential Of Swertia Chirayitamentioning

confidence: 99%

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

Dey

Singh

Suluvoy

et al. 2020

Nat. Prod. Bioprospect.

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Diabetes mellitus is referred as common metabolic abnormalities characterized as hyperglycemia, mainly caused due to insufficient production of insulin at cellular level or/and defects in insulin action. Such an endocrine disorder is responsible for serious health problems and its worldwide prevalence is rapidly increasing. Common management of diabetes by oral administration of drugs without creating any side effects is still considered a challenging task and increasing cost of conventional medicine in developing countries is another matter of concern. To address these issues, traditional preparations of herbal plant extracts in the form of medicines already gained immense attention. Swertia chirayita is one among such plants which is known for its hypoglycemic potential. Numerous chemical constituents with promising pharmacological properties have been identified from such plant extracts but still, such compounds have not been well characterized, specifically against human application. Hence, more research efforts are necessitated to understand exact mechanism of such compounds and to develop overall safety of such plant formulations. Present review clearly represents antidiabetic properties of Swertia chirayita extract, strategies to be taken to strengthen its safety application on humans and biotechnological interventions that ensure conservation of such endangered species to promote its future application in modern medicine. Graphic Abstract

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Effect of different fractions of Swertia chirayita on the blood sugar level of albino rats

Cited by 30 publications

References 2 publications

In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India.

In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India.

A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal Plant

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

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