Effect of Different Frequencies of Electroacupuncture on Post-Stroke Dysphagia in Mice

Yao, Shuqi; Liu, Yun; Cui, Shuai; Li, Hongzhu; Ji, Chang; Yuan, Si; Ye, Qiuping; Zhang, Yu; Xu, Nenggui

doi:10.1007/s12031-020-01580-1

Cited by 16 publications

(19 citation statements)

References 37 publications

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“…In summary, we chose the Baihui (GV20) point and Zusanli (ST36) point as the EA preconditioning protocol because they are often used in clinical treatment and have good curative effects. We selected the electrical component of the treatment (stimulus and frequency) based on previous research [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Preconditioning Reduces Oxidative Stress in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats by Regulating Iron Metabolism Pathways

Liang

Tang

Song

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Oxidative stress is an important mechanism of cerebral ischemia-reperfusion injury. Ferroptosis caused by iron overload after cerebral ischemia-reperfusion is considered a common cause of oxidative stress. Many recent studies have shown that electroacupuncture (EA) can regulate the expression of inflammatory factors, and the use of electroacupuncture preconditioning can produce a protective effect, which can reduce injury after cerebral ischemia and reperfusion. We aimed to assess whether EA could be used to reduce oxidative stress. Methods. The oxidative stress level of rats during the acute phase of cerebral ischemia and reperfusion was assessed with and without preconditioning with EA. Molecular biology methods were used to detect iron metabolism and oxidative stress-related proteins. Results. Rats that had EA preconditioning had lower infarct volumes than rats in the control group. Furthermore, western blot analysis showed that the expression of iron metabolism-related protein FPN-1 was higher in the intervention group than in the model group after reperfusion. In this regard, further investigation also demonstrated higher expression of glutathione and glutathione peroxidase-4, and lower reactive oxygen species values in the brain tissue of the EA group were compared with those of the control group rats. Conclusions. Electroacupuncture preconditioning can reduce oxidative stress after cerebral ischemia-reperfusion by regulating iron overload.

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Section: Discussionmentioning

confidence: 99%

Electroacupuncture Preconditioning Reduces Oxidative Stress in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats by Regulating Iron Metabolism Pathways

Liang

Tang

Song

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Acupuncture is conducive to neuron protection, prominent formation, and neural stem cell proliferation. Also, acupuncture promotes the repair of nerve function [15]. Some studies have confirmed that acupuncture can improve motor dysfunction, quality of life, and independence of stroke patients [6,12].…”

Section: Introductionmentioning

confidence: 99%

“…Acupuncture is conducive to neuron protection, prominent formation, and neural stem cell proliferation. Also, acupuncture promotes the repair of nerve function [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Effects of Acupuncture for Stroke Patients Recovery

Guo

Cheng

2022

Journal of Healthcare Engineering

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Stroke is assumed as one of the common cerebrovascular diseases that endangers human health and life. Its incidence and mortality rates are high, while survivors (50% to 70%) suffer from different degrees of disability. Hemiplegia is a common disability after stroke, mainly manifested as muscle weakness of the affected side, limb spasm, and limited activity, which severely impacts a patient’s daily life. There are various rehabilitation methods for stroke hemiplegia, including modern rehabilitation medicine, motor therapy, acupuncture, and rehabilitation robot. The cost and effect of different rehabilitation methods are not the same. It is the focus to find an economical and effective rehabilitation method. In this paper, 128 stroke patients aged 41 to 73 hospitalized between January 2019 and January 2021 were analyzed. The intervention group used standard physical therapy and traditional acupuncture therapy, and the control group only used standard physical therapy. We used RStudio 1.1.419 (RStudio Corporation) for analysis. Experimental results show that the short-term efficacy of the intervention group is better than that of the control group. The intervention group was better than the control group in recovery from injury during rehabilitation, degree of muscle spasm, self-care ability in daily life, and overall degree of damage. In the long-term efficacy analysis, we can see that with the increase in the number of acupuncture, the efficacy of the intervention group is still better than that of the control group. Compared with physical rehabilitation alone, acupuncture has better short-term, and long-term clinical effects for stroke patients improves motor dysfunction and improves the quality of life and independence of stroke patients. With the increase in the number of acupuncture treatments, the patient’s rehabilitation effect will be better.

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“…For motor functional recovery, low-frequency electroacupuncture could promote recovery of motor function after focal cerebral ischemic injury in rats [ 35 ]. Electroacupuncture in the 2-Hz group had an obvious effect on dysphagia after stroke in mice [ 36 ]. However, there are few researches on the effect of different frequencies of electroacupuncture or opposing needling on motor cortex excitability in healthy participants or in patients with post-stroke hemiplegia.…”

Section: Discussionmentioning

confidence: 99%

Effect of opposing needling on motor cortex excitability in healthy participants and in patients with post-stroke hemiplegia: study protocol for a single-blind, randomised controlled trial

et al. 2021

Trials

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Background Opposing needling has an obvious curative effect in the treatment of post-stroke hemiplegia; however, the mechanism of the opposing needling in the treatment of post-stroke hemiplegia is still not clear. The purpose of this study is to investigate the effect of opposing needling on the excitability of primary motor cortex (M1) of healthy participants and patients with post-stroke hemiplegia, which may provide insight into the mechanisms of opposing needling in treating post-stroke hemiplegia. Methods This will be a single-blind, randomised, sham-controlled trial in which 80 healthy participants and 40 patients with post-stroke hemiplegia will be recruited. Healthy participants will be randomised 1:1:1:1 to the 2-Hz, 50-Hz, 100-Hz, and sham electroacupuncture groups. Patients with post-stroke hemiplegia will be randomised 1:1 to the opposing needling or conventional treatment groups. The M1 will be located in all groups by using neuroimaging-based navigation. The stimulator coil of transcranial magnetic stimulation (TMS) will be moved over the left and right M1 in order to identify the TMS hotspot, followed by a recording of resting motor thresholds (RMTs) and motor-evoked potentials (MEPs) of the thenar muscles induced by TMS before and after the intervention. The primary outcome measure will be the percent change in the RMTs of the thenar muscles at baseline and after the intervention. The secondary outcome measures will be the amplitude (μV) and latency (ms) of the MEPs of the thenar muscles at baseline and after the intervention. Discussion The aim of this trial is to explore the effect of opposing needling on the excitability of M1 of healthy participants and patients with post-stroke hemiplegia. Trial registration Chinese Clinical Trial Registry ChiCTR1900028138. Registered on 13 December 2019.

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Effect of Different Frequencies of Electroacupuncture on Post-Stroke Dysphagia in Mice

Cited by 16 publications

References 37 publications

Electroacupuncture Preconditioning Reduces Oxidative Stress in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats by Regulating Iron Metabolism Pathways

Electroacupuncture Preconditioning Reduces Oxidative Stress in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats by Regulating Iron Metabolism Pathways

Clinical Effects of Acupuncture for Stroke Patients Recovery

Effect of opposing needling on motor cortex excitability in healthy participants and in patients with post-stroke hemiplegia: study protocol for a single-blind, randomised controlled trial

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