Effect of different glycosaminoglycans in a guinea-pig carotid artery thrombosis model

Mattar, L.; Maffei, Francisco H.A.; Nader, Helena B.; Dietrich, Carl P.; Curi, P. R.

doi:10.1016/0049-3848(94)90171-6

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Antithrombotic Activity Of Other Heparin-like Compounds1

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2001

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“…Chondroitin sulfate from cartilage and dermatan sulfate from pig skin show no effect. When tested in a guinea pig arterial thrombosis model (17), pancreatic heparan sulfate also showed a potent inhibitory effect comparable to heparin (Figure 8). It should be mentioned that the type of thrombus is different in arterial and venous vessels.…”

Section: Antithrombotic Activity Of Other Heparin-like Compoundsmentioning

confidence: 99%

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Nader

Pinhal

Baú

et al. 2001

Braz J Med Biol Res

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The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.

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Section: Antithrombotic Activity Of Other Heparin-like Compoundsmentioning

confidence: 99%