Effect of Different Grades of HPMC and Eudragit on Drug Release Profile of Doxofylline Sustained Release Matrix Tablets and Ivivc Studies

Panda, Niranjan; Reddy, A V Gurava; Reddy, G. Venkata; Panda, Kanhu Charan

doi:10.7897/2230-8407.068100

Cited by 8 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The release data were evaluated to predict the release profile of the drug from the hydrogel and fitted into a suitable mathematical model: zero-order, first-order, Higuchi, Korsmayer−Peppas, and Hixson− Crowell kinetics. 6,33,34 The following equation was used for the zero-order model…”

mentioning

confidence: 99%

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

et al. 2021

View full text Add to dashboard Cite

This study focuses on the synthesis of poly(ε-caprolactone) diacrylate (PCLDA) for the fabrication of micelle-cross-linked sodium AMPS wound dressing hydrogels. The novel synthetic approach of PCLDA is functionalizing a PCL diol with acrylic acid. The influences of varying the PCL diol/AA molar ratio and temperature on the suitable conditions for the synthesis of PCLDA are discussed. The hydrogel was synthesized through micellar copolymerization of sodium 2-acrylamido-2-methylpropane sulfonate (Na-AMPS) as a basic monomer and PCLDA as a hydrophobic association monomer. In this study, an attempt was made to develop new hydrogel wound dressings meant for the release of antibacterial drugs (ciprofloxacin and silver sulfadiazine). The chemical structures, morphology, porosity, and water interaction of the hydrogels were characterized. The hydrogels’ swelling ratio and water vapor transmission rate (WVTR) showed a high swelling capacity (4688–10753%) and good WVTR (approximately 2000 g·m–2·day–1), which can be controlled through variation of the PCLDA concentration. The mechanical property results confirmed that PCLDA improved the mechanical properties of the hydrogel; the stress increased from 37 to 68 kPa, and the strain increased from 198 to 360% with increasing PCLDA (0–30% wt of Na-AMPS). These hydrogels presented no cytotoxicity based on over 70% cell viability responses (L929 fibroblasts) using an in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Additionally, the drug release mechanism, kinetic models, and antibacterial activity were determined. The results demonstrated that antibiotics were released from the hydrogel with a Fickian diffusion mechanism and antibacterial activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus). Based on the results obtained, and bearing in mind that further progress still needs to be made, the fabricated hydrogels show considerable potential for meeting the stringent property requirements of hydrogel wound dressings.

show abstract

mentioning

confidence: 99%

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This technique is also called as fusion method. The mixture is left for cooling and washing is done to remove the unreacted substrates [22].…”

Section: Melt-based Synthesismentioning

confidence: 99%

A Novel Revolutionary Approach of a Synthesis and Application of Targeted Nanosponge Drug Delivery

Raj Behura

2021

GJPPS

View full text Add to dashboard Cite

The novel and development of nanotechnology have brought a term targeted drug delivery system. Targeting a molecule to a specific site has brought a certain pharmacological action. Nanosponge is a part of nanotechnology which is both hydrophilic and lipophilic in nature. They are colloidal carriers which improve the aqueous solubility of the poorly soluble drug by enhancing and improving the physical and chemical stability and improving the permeability and bioavailability in the body tissues. Nanosponge are tiny sponges which are in the size of colloidal sizes and nanosized cavity. There general application can be seen in oral administration, parenteral administration, topical administration and available in the form of hydrogel. The current review discussion various methods of synthesis and application of nanosponges.

show abstract

“…The effect of different grades of HPMC and Eudragit on the drug release of doxofylline matrix tablets was evaluated by Panda et al . (17). The product was manufactured using wet granulation using various grades and ratios to optimize the dissolution profile.…”

Section: Introductionmentioning

confidence: 99%

Power of the Dissolution Test in Distinguishing a Change in Dosage Form Critical Quality Attributes

Gray¹

2018

AAPS PharmSciTech

View full text Add to dashboard Cite

For a dissolution method to be considered relevant to in vivo performance, the dissolution data profiles should show discrimination or meaningful change when there is a change in critical material attributes (CMAs) and critical product properties (CPPs). The dissolution test has been shown repeatedly to have the power to distinguish between significant changes in active pharmaceutical ingredient (API), formulation, and process that relate to the release mechanism of the in vivo performance. Examples will be discussed in the literature where the effects of formulation, drug substance, and manufacturing variables have been measured by dissolution testing. There will be a suggested plan on how to develop and challenge a discriminating method that may be utilized for regulatory purposes. A brief review of other challenges and considerations regarding discriminatory dissolution testing is presented.

show abstract

Effect of Different Grades of HPMC and Eudragit on Drug Release Profile of Doxofylline Sustained Release Matrix Tablets and Ivivc Studies

Cited by 8 publications

References 9 publications

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

A Novel Revolutionary Approach of a Synthesis and Application of Targeted Nanosponge Drug Delivery

Power of the Dissolution Test in Distinguishing a Change in Dosage Form Critical Quality Attributes

Contact Info

Product

Resources

About