Aluminum alloys have been widely utilized in automobiles, aircraft, building structures, and high-speed railways industries due to their excellent structural and mechanical properties. Surface oxide film removal prior to aluminum alloy welding and old paint removal prior to repainting aluminum alloy surfaces are critical factors in ensuring the welding quality and service life of aluminum alloy products. Because of its unique advantages, such as environmental protection and precision control, laser-controlled cleaning has great application potential as a surface cleaning technology in removing oxide films and paint layers on aluminum alloy surfaces. In this paper, the mechanism of laser cleaning of oxide films and paint layers on aluminum alloy is discussed. Furthermore, the impact of various processing parameters such as laser beam power, energy density, scanning speed, and so on is analyzed in detail. After laser cleaning, the corrosion resistance, welding performance, adhesive performance, and other properties of the aluminum alloy are optimized. This paper also discusses several real-time detection technologies for laser cleaning. A summary and the development trend are provided at the end of the paper.